Corrigendum: Commentary: Evaluation of Models of Parkinson's Disease
- 1Molecular and Clinical Pharmacology, Faculty of Medicine, University of Chile, Santiago, Chile
- 2Departamento de Ciencia Básicas, Facultad de Ciencias, Universidad Santo Tomas, Viña del Mar, Chile
A corrigendum on
Commentary: Evaluation of Models of Parkinson's Disease
by Muñoz, P., Paris, I., and Segura-Aguilar, J. (2016). Front. Neurosci. 10:161. doi: 10.3389/fnins.2016.00161
It was an error in the structure of dopamine o-quinone published in the commentary on Evaluation of models of Parkinson's disease since the benzene ring contained an extra double bound between the carbonyls. The actual structure of dopamine o-quinone is the correct structure.
Figure 1. Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity. Astrocytes secrete GSTM2 which is internalized by dopaminergic neurons in order to increase their protection against aminochrome. Dopamine oxidation to neuromelanin is a harmless pathway due to the presence of DT-diaphorase and GSTM2 that prevent aminochrome-dependent neurotoxicity by inhibiting the formation of alpha-synuclein (SNCA) neurotoxic oligomers, mitochondrial dysfunction, oxidative stress, autophagy, and proteasome dysfunction and endoplasmic reticulum stress.
All authors listed, have made substantial, direct and intellectual contribution to the work, and approved it for publication.
Supported by University of Chile (ENL014/14).
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Keywords: dopamine o-quinone, dopamine, aminochrome, neurodegenration, astrocytes, dopaminergic neurons
Citation: Muñoz P, Paris I and Segura-Aguilar J (2016) Corrigendum: Commentary: Evaluation of Models of Parkinson's Disease. Front. Neurosci. 10:320. doi: 10.3389/fnins.2016.00320
Received: 16 May 2016; Accepted: 24 June 2016;
Published: 07 July 2016.
Edited and reviewed by: Mark R. Cookson, National Institutes of Health, USA
Copyright © 2016 Muñoz, Paris and Segura-Aguilar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Juan Segura-Aguilar, email@example.com