Original Research ARTICLE
Transcranial direct current stimulation (tDCS) can modulate EEG complexity of children with autism spectrum disorder
- 1Yanshan University, China
- 2Beijing Normal University, China
- 3Department of Biomedical Sciences, School of Medicine Greenville, University of South Carolina, United States
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder which affects the developmental trajectory in several behavioral domains, including impairments of social communication, cognitive and language abilities. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique, and it was used for modulating the brain disorders. In this paper, we enrolled thirteen ASD children (11 males and 2 females; mean±SD age: 6.5±1.7 years) to participate in our trial. Each patient received 10 treatments over the dorsolateral prefrontal cortex (DLPFC) once every two days. Also, we enrolled thirteen ASD children (11 males and 2 females; mean±SD age: 6.3±1.7 years) waiting to receive therapy as controls. A maximum entropy ratio (MER) method was adapted to measure the change of complexity of EEG series. It was found that the MER value significantly increased after tDCS. This study suggests that tDCS may be a helpful tool for the rehabilitation of children with ASD.
Keywords: Autism spectrum disorder (ASD), transcranial direct current stimulation (tDCS), Electroencephalography (EEG), Complexity, maximum entropy ratio (MER)
Received: 14 Jul 2017;
Accepted: 14 Mar 2018.
Edited by:Gabriel A. Silva, University of California, San Diego, United States
Reviewed by:Vassiliy Tsytsarev, University of Maryland, College Park, United States
Waldemar Karwowski, University of Central Florida, United States
Copyright: © 2018 Kang, Cai, Han, Tong, Li, Sokhadze, Casanova, Ouyang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Xiaoli Li, Beijing Normal University, Beijing, China, firstname.lastname@example.org