Regulation of chromatin structure during neural development
- 1Graduate School of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
- 2International Research Center for Neurointelligence (IRCN), Japan
The regulation of genome architecture is a key determinant of gene transcription patterns and neural development. Advances in methodologies based on chromatin conformation capture (3C) have shed light on the genome-wide organization of chromatin in developmental processes. Here we review recent discoveries regarding the regulation of three-dimensional chromatin conformation, including promoter-enhancer looping and the dynamics of large chromatin domains such as topologically associated domains (TADs) and A/B compartments. We conclude with perspectives on how these conformational changes govern neural development and may go awry in disease states.
Keywords: neural development, Chromatin, 3C, TAD, A/B compartment
Received: 06 Sep 2018;
Accepted: 09 Nov 2018.
Edited by:Mareike Albert, Max-Planck-Institut für Molekulare Zellbiologie und Genetik, Germany
Reviewed by:Tran Tuoc, Universitätsmedizin Göttingen, Germany
Boyan Bonev, German Research Center for Environmental Health (HZ), Germany
Copyright: © 2018 Kishi and Gotoh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: PhD. Yusuke Kishi, Graduate School of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, 113-0033, Japan, firstname.lastname@example.org