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Mitochondrial Dysfunction and Neurodegeneration

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Front. Neurosci. | doi: 10.3389/fnins.2018.00898

Potential Role of Mic60 / Mitofilin in Parkinson’s Disease

  • 1University of Pittsburgh, United States

There are currently no treatments that hinder or halt the inexorable progression of Parkinson disease (PD). While the etiology of PD remains elusive, evidence suggests that early dysfunction of mitochondrial respiration and homeostasis play a major role in PD pathogenesis. The mitochondrial structural protein Mic60, also known as mitofilin, is crucial for maintaining mitochondrial architecture and function. Loss of Mic60 is associated with detrimental effects on mitochondrial homeostasis. Growing evidence now implicates Mic60 in the pathogenesis of PD. In this review, we discuss the data supporting a role of Mic60 and mitochondrial dysfunction in PD. We will also consider the potential of Mic60 as a therapeutic target for treating neurological disorders.

Keywords: mitofilin/Mic60, mitochondrial, Parkinson's disease, neurodegeneration, mitochondrial dynamics

Received: 05 Oct 2018; Accepted: 16 Nov 2018.

Edited by:

Victor Tapias, Feil Family Brain & Mind Research Institute, Weill Cornell Medicine, United States

Reviewed by:

Ruth G. Perez, Texas Tech University Health Sciences Center El Paso, United States
Kim Tieu, Florida International University, United States  

Copyright: © 2018 Van Laar, Otero, Hastings and Berman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Victor S. Van Laar, University of Pittsburgh, Pittsburgh, United States, viv2@pitt.edu
Dr. Sarah B. Berman, University of Pittsburgh, Pittsburgh, United States, bermans@upmc.edu