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Central Nervous System Extracellular Vesicles

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Front. Neurosci. | doi: 10.3389/fnins.2019.00163

Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders

  • 1Kazan Federal University, Russia
  • 2School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, University of Nottingham, United Kingdom
  • 3Kazan State Medical University, Russia

The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration including that of the nervous system. EVs transfer bioactive proteins and lipids, RNA and microRNAs, which play a relevant role in EV-mediated intercellular communication. The immunomodulatory, anti-inflammatory and neuroprotective effects of mesenchymal stem cells-derived EVs have been well studied, knowledge of this paracrine mechanism and the availability of these cells, positions mesenchymal stem cells as a potential source of EVs for cell free therapy for a variety of regenerative and nervous system disorders. In this review, we focus on the immunomodulatory and neuroprotective effects of stem cells-derived EVs within in vitro and in vivo models of nerve disorders.

Keywords: extracellular vesicles, Immunomodulatory effects, neuroprotective effects, Mesenchymal Stem Cells, nerve disorders

Received: 20 Nov 2018; Accepted: 12 Feb 2019.

Edited by:

Grant T. Corbett, Brigham and Women's Hospital, Harvard Medical School, United States

Reviewed by:

VERONICA PEREZ DE LA CRUZ, Instituto Nacional de Neurología y Neurocirugía (INNN), Mexico
Susanna Amadio, Fondazione Santa Lucia (IRCCS), Italy  

Copyright: © 2019 Galieva, James, Mukhamedshina and Rizvanov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: MD, PhD. Yana O. Mukhamedshina, Kazan Federal University, Kazan, 420008, Tatarstan, Russia, yana.k-z-n@mail.ru