@ARTICLE{10.3389/fnins.2019.00204, AUTHOR={Chen, Zikuan and Fu, Zening and Calhoun, Vince}, TITLE={Phase fMRI Reveals More Sparseness and Balance of Rest Brain Functional Connectivity Than Magnitude fMRI}, JOURNAL={Frontiers in Neuroscience}, VOLUME={13}, YEAR={2019}, URL={https://www.frontiersin.org/articles/10.3389/fnins.2019.00204}, DOI={10.3389/fnins.2019.00204}, ISSN={1662-453X}, ABSTRACT={Conventionally, brain function is inferred from the magnitude data of the complex-valued fMRI output. Since the fMRI phase image (unwrapped) provides a representation of brain internal magnetic fieldmap (by a constant scale difference), it can also be used to study brain function while providing a more direct representation of the brain's magnetic state. In this study, we collected a cohort of resting-state fMRI magnitude and phase data pairs from 600 subjects (age from 10 to 76, 346 males), decomposed the phase data by group independent component analysis (pICA), calculated the functional network connectivity (pFNC). In comparison with the magnitude-based brain function analysis (mICA and mFNC), we find that the pFNC matrix contains fewer significant functional connections (with p-value thresholding) than the mFNC matrix, which are sparsely distributed across the whole brain with near/far interconnections and positive/negative correlations in rough balance. We also find a few of brain rest sub-networks within the phase data, primarily in subcortical, cerebellar, and visual regions. Overall, our findings offer new insights into brain function connectivity in the context of a focus on the brain's internal magnetic state.} }