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Neuroendocrine Research in Health and Disease

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Front. Neurosci. | doi: 10.3389/fnins.2019.00378

Role of leptin in mood disorder and neurodegenerative disease

 Bingjin Li1, 2*,  Xiaohan Zou2 and shuohui gao3
  • 1Jilin University, China
  • 2Second Affiliated Hospital of Jilin University, China
  • 3China-Japan Union Hospital, Jilin University, China

The critical regulatory role of leptin in the neuroendocrine system has been widely reported. Significantly, leptin can improve learning and memory, affect hippocampal synaptic plasticity, exert neuroprotective efficacy and reduce the risk of several neuropsychiatric diseases. In terms of depression,leptin could modulate the levels of neurotransmitters, neurotrophic factors and reverse the dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis. At the same time, leptin affects neurological diseases during the regulation of metabolic homeostasis. With regards to neurodegenerative diseases,leptin can affect neurodegenerative diseases via neuroprotection, mainly including Alzheimer's disease (AD) and Parkinson's disease (PD). This review will summarize the mechanisms of leptin signalling within the neuroendocrine system with respect to these diseases and discuss the therapeutic potential of leptin.

Keywords: Leptin, neurodegeneration, Mood Disorders, Depression, Neuroprotection

Received: 04 Sep 2018; Accepted: 02 Apr 2019.

Edited by:

Yu-Feng Wang, Harbin Medical University, China

Reviewed by:

Chun-Ping Chu, Yanbian University, China
Taixing Cui, University of South Carolina, United States  

Copyright: © 2019 Li, Zou and gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Bingjin Li, Jilin University, Changchun, China,