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Front. Neurosci. | doi: 10.3389/fnins.2019.00478

Neural Dynamics of Olfactory Perception: Low- and High-frequency Modulations of Local Field Potential Spectra in Mice Revealed by an Oddball Stimuli

Jeungeun Kum1, Jin Won Kim2,  Oliver Braubach1, Jong-Gyun Ha2, Hyungju Cho2,  Chang-Hoon Kim3,  Hio-Been Han1,  Jee Hyun Choi1* and Joo-Heon Yoon3*
  • 1Korea Institute of Science and Technology (KIST), South Korea
  • 2Severance Hospital, South Korea
  • 3Korea Mouse Phenotyping Center (KMPC), South Korea

Recent brain connectome studies have evidenced distinct and overlapping brain regions involved in processing olfactory perception. However, neural correlates of hypo- or anosmia in olfactory disorder patients are poorly known. Furthermore, the bottom-up and top-down processing of olfactory perception have not been well-documented, giving difficulty in locating the disease foci of olfactory disorder patients. The primary aim of this current study is to characterize the bottom-up process of the neural dynamics across peripheral and central brain regions in anaesthetized mice. We particularly characterized the neural oscillations of local field potential (LFP) in olfactory epithelium (OE), olfactory blub (OB), prefrontal cortex (PFC), and hippocampus (HC) during an olfactory oddball paradigm in urethane anaesthetized mice. Odorant presentations evoked neural oscillations across slow and fast frequency bands including delta (1–4 Hz), theta (6–10 Hz), beta (15–30 Hz), low gamma (30–50 Hz), and high gamma (70–100 Hz) in both peripheral and central nervous system, and the increases were more prominent to infrequently presented odorant. During 5 sec odorant exposure, the oscillatory responses in power were persistent in OE, OB, and PFC, whereas neural oscillations of HC increased only for short time at stimulus onset. These oscillatory responses in power were insignificant in both peripheral and central regions of the ZnSO4-treated anosmia model. These results suggest that olfactory stimulation induce LFP oscillations both in the peripheral and central nervous system and suggest the possibility of linkage of LFP oscillations in brain to the oscillations in the peripheral olfactory system.

Keywords: oddball paradigm, mice (inbred B6), local field potential, Neural oscillations, Olfaction, Attention, anterior cingulate cortex, Primary olfactory cortex, Anterior olfactory

Received: 24 Jan 2019; Accepted: 26 Apr 2019.

Edited by:

Kathrin Ohla, Institute of Neuroscience and Medicine, Jülich Research Centre, Germany

Reviewed by:

Masahiro Yamaguchi, Kochi Medical School, Japan
Diego Restrepo, University of Colorado Denver, United States  

Copyright: © 2019 Kum, Kim, Braubach, Ha, Cho, Kim, Han, Choi and Yoon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Jee Hyun Choi, Korea Institute of Science and Technology (KIST), Bongdong-eup, South Korea, jeechoi@kist.re.kr
Prof. Joo-Heon Yoon, Korea Mouse Phenotyping Center (KMPC), Seoul, South Korea, JHYOON@yuhs.ac