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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurosci. | doi: 10.3389/fnins.2019.00758

Potential immunotherapeutic targets on myeloid cells for neurovascular repair after ischemic stroke

 Ziyu Zhu1, Li Zheng1,  Yan Li1,  Tingting Huang1, Yu-Chieh Chao1, Lijun Pan2, Hui Zhu1,  Yanhua Zhao1, Weifeng Yu1 and  Peiying Li3*
  • 1Department of Anesthesiology, Renji Hospital, Shanghai JiaoTong University School of Medicine, China
  • 2Department of Radiology, Renji Hospital, Shanghai JiaoTong University School of Medicine, China
  • 3Renji Hospital, Shanghai JiaoTong University School of Medicine, China

Neurological deficits and cognitive dysfunctions caused by acute ischemic stroke pose enormous burden to the stroke families and the communities. Restoration of the normal function of the neurovascular unit following ischemic stroke is critical for improving neurological recovery and cognitive functions after stroke. Recent evidences suggest that the myeloid cells including both the resident microglia and infiltrating monocytes/macrophages and neutrophils are highly plastic in response to the environmental cues. They intimately interact with multiple components of the neurovascular unit in response to the alarmins, danger associated pattern molecules (DAMPs) and other signals released from the ischemic brain. The aim of this review is to discuss the reciprocal interactions between the myeloid cells and the ischemic neurovascular unit during the late repair phase of cerebral ischemic stroke. We also summarize potential immunotherapeutic targets on myeloid cells and new therapeutic approaches targeting myeloid cells, such as cell transplantation, mitochondrial dynamic and extracellular vesicles-based therapy and et al to enhance neurovascular repair for better stroke recovery.

Keywords: stroke;, Neurovascular unit (NVU), brain repair, myeloid cell, Microglia, macrophage, Neutrophil

Received: 01 Apr 2019; Accepted: 08 Jul 2019.

Edited by:

Johannes Boltze, University of Warwick, United Kingdom

Reviewed by:

Ken Arai, Massachusetts General Hospital and Harvard Medical School
Lidia Garcia-Bonilla, Weill Cornell Medicine, Cornell University, United States
Thomas Blank, University of Freiburg, Germany
Luke M. Healy, McGill University, Canada  

Copyright: © 2019 Zhu, Zheng, Li, Huang, Chao, Pan, Zhu, Zhao, Yu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Peiying Li, Renji Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China, peiyingli.md@gmail.com