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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurosci. | doi: 10.3389/fnins.2019.00820

Low-frequency pulsed magnetic field improves depression-like behaviors and cognitive impairments in depressive rats mainly via modulating synaptic function

Jiajia Yang1, Ling Wang1,  Faqii Wang1,  Xiaoxuan Tang1, Peng Zhou1,  Chenguang Zheng1, Rong Liang1 and  Dong Ming1*
  • 1Tianjin University, China

Transcrainal magnetic stimulation (TMS) has shown great promise as a medical treatment of depression. The effectiveness of TMS treatment at high frequency has been well investigated, however, the low-frequency TMS in depression treatment has rarely been investigated in depression-induced cognitive deficits. Herein, this study was carried out to assess the possible modulatory role of low-frequency pulsed magnetic field (LFPMF) on reversing cognitive impairment in a model of depression induced by chronic unpredictable stress (CUS). Wistar rats were randomly allocated into four groups as follow: a control group (CON), a control applied with LFPMF (CON+LFPMF), a chronic unpredictable stress (CUS), and a CUS treated with LFPMF (CUS+LFPMF). During 8 weeks of CUS, comparing to those in CON group animals not only gained less weight, but also exhibited anhedonia, anxiety, and cognitive decline in behavioral tests. After two-week treatment of LFPMF, a 20mT, 1Hz magnetic stimulation, it reversed the impairment of spatial cognition as well as hippocampal synaptic function including long-term potentiation and related protein expression. Thus, LFPMF has shown effectively improvements on depressant behavior and cognitive dysfunction in CUS rats, possibly via regulating synaptic function.

Keywords: Depression, low-frequency pulsed magnetic field, cognition function, synaptic plasticity, neuronal oscillation

Received: 28 Feb 2019; Accepted: 23 Jul 2019.

Edited by:

Alexander Dityatev, German Center for Neurodegenerative Diseases (DZNE), Germany

Reviewed by:

Brent Winslow, Design Interactive (United States), United States
Vishnu Suppiramaniam, Auburn University, United States  

Copyright: © 2019 Yang, Wang, Wang, Tang, Zhou, Zheng, Liang and Ming. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Dong Ming, Tianjin University, Tianjin, 300072, China, richardming@tju.edu.cn