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Front. Neurosci. | doi: 10.3389/fnins.2019.00871

Reduction of glycolysis intermediate concentrations in the cerebrospinal fluid of Alzheimer`s Disease patients

  • 1Leibniz Institute of Plant Biochemistry, Germany
  • 2Martin Luther University of Halle-Wittenberg, Germany

The profile of 122 metabolites in the cerebrospinal fluid (CSF) of patients suffering from Alzheimer’s disease (AD) and controls was studied. Among the 122 metabolites analyzed, 62 could be detected. Statistically significant differences between the AD and control group were only detected for metabolites of the glycolysis. Thus, accurate quantification of 11 glycolytic metabolites was done. At this, we detected a significant reduction of five of them, namely phosphoenolpyruvate, 2-phosphoglycerate, 3-phosphoglycerate, pyruvate and dihydroxyacetone phosphate in the AD CSF compared to controls. These results correlate with the known reduction of glucose metabolism in the brain of patients with AD and indicate that metabolic analysis of the central carbon metabolism can be a potential tool in AD diagnostic. Although the ROC analyses of the metabolites do not reach the level of the diagnostic quality of AD biomarkers, the combination of glycolysis metabolites with the established biomarkers led to an improvement in sensitivity and specificity. Thus, metabolic markers could increase diagnostic safety and represent an approach to characterize the progression of the disease.

Keywords: Alzheheimer's disease, metabolomcis, Glycolysis, Cerebrospinal, fluid, LC-MS

Received: 12 Apr 2019; Accepted: 02 Aug 2019.

Edited by:

Sylvain Lehmann, Université de Montpellier, France

Reviewed by:

Constance DELABY, Université de Montpellier, France
Min Shi, University of Washington, United States  

Copyright: © 2019 Bergau, Maul, Rujescu, Simm and Navarrete Santos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Alexander Navarrete Santos, Martin Luther University of Halle-Wittenberg, Halle, 06108, Saxony-Anhalt, Germany,