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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurosci. | doi: 10.3389/fnins.2019.01011

A Multi-Channel Asynchronous Neurostimulator with Artifact Suppression for Neural Code-Based Stimulations

  • 1University of Southern California, United States

A novel neurostimulator for generating neural code-based, precise, asynchronous electrical stimulation pulses is designed, fabricated and characterized. Through multiplexing, this system can deliver constant current biphasic pulses, with arbitrary temporal patterns and pulse parameters to 32 electrodes using one pulse generator. The design also features a stimulus artifact suppression technique that can be integrated with commercial amplifiers. Using an array of CMOS switches, electrodes are disconnected from recording amplifiers during stimulation, while the input of the recording system is shorted to ground through another CMOS switch to suppress ringing in the recording system. The timing of the switches used to block and suppress the stimulus artifact are crucial and are determined by the electrochemical properties of the electrode. This system allows stimulation and recording from the same electrodes to monitor local field potentials with short latencies from the region of stimulation for achieving feedback control of neural stimulation. In this way, timing between each pulse is controlled by inputs from an external source and stimulus magnitude is controlled by feed-back from neural response from the region of stimulation. The system was implemented with low-power and compact packaged microchips to constitute an effective, cost-efficient and miniaturized neurostimulator. The device has been first evaluated in phantom preparations and then tested in hippocampi of behaving rats. Benchtop results demonstrate the capability of the stimulator to generate arbitrary spatio-temporal pattern of stimulation pulses dictated by random number generators to control magnitude and timing between each individual biphasic pulse. In vivo results show that evoked potentials elicited by the neurostimulator can be recorded ~2ms after the termination of stimulus pulses from the same electrodes where stimulation pulses are delivered, whereas commercial amplifiers without such an artifact suppression typically result in tens to hundreds of milliseconds recovery period. This neurostimulator design is desirable in a variety of neural interface applications, particularly hippocampal memory prosthesis aiming to restore cognitive functions by reinstating neural code transmissions in the brain.

Keywords: Brain, deep brain simulation, Cortical Prosthesis, intracortical stimulation, multiplexing, Artifact suppression

Received: 08 Apr 2019; Accepted: 05 Sep 2019.

Copyright: © 2019 Elyahoodayan, Jiang, Xu and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Ms. Sahar Elyahoodayan, University of Southern California, Los Angeles, United States, elyahood@usc.edu