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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurosci. | doi: 10.3389/fnins.2019.01134

Alterations in cortical thickness in young male patients with childhood-onset adult growth hormone deficiency: a morphometric MRI study

 Hongbo Yang1,  Kang Li1,  Xinyu Liang2, Bin Gu2, Linjie Wang1,  Gaolang Gong2, Hui You1, Feng Feng1, Bo Hou1,  Fengying Gong1, Huijuan Zhu1* and  Hui Pan1*
  • 1Peking Union Medical College Hospital (CAMS), China
  • 2Beijing Normal University, China

Background: The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis plays an important role in brain structure and maintenance of brain function. There is a close correlation between serum GH and IGF1 levels and age-related cognitive function. The effects of childhood-onset growth hormone deficiency on brain morphology are underestimated so far.
Methods: In this cross-sectional study, T1-weighted magnetic resonance imaging was assessed in 17 adult males with childhood-onset growth hormone deficiency and 17 age and gender-matched healthy controls. The cortical thickness was analyzed and compared between the two groups of subjects. Effects of disease status and hormone levels on cortical thickness were also evaluated.
Results: Although there was no difference in whole brain volume or grey matter volume between the two groups, there was decreased cortical thickness in the parahippocampal gyrus, posterior cingulate gyrus and occipital visual syncortex in the adult growth hormone deficiency (AGHD) group, and increased cortical thickness in a partial area of the frontal lobe, parietal lobe and occipital visual syncortex in AGHD group. Cortical thickness of the posterior cingulum gyrus was prominently associated with FT3 serum levels only in control group after adjusting of IGF-1 levels.
Conclusions: These results suggest that young adult male patients with childhood-onset growth hormone deficiency have alterations in cortical thickness in different brain lobes/regions.

Keywords: Childhood-onset adult growth hormone deficiency, cortical thickness, Structure MRI, Growth Hormone, Insulin-like growth factor 1

Received: 08 May 2019; Accepted: 08 Oct 2019.

Copyright: © 2019 Yang, Li, Liang, Gu, Wang, Gong, You, Feng, Hou, Gong, Zhu and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Mx. Huijuan Zhu, Peking Union Medical College Hospital (CAMS), Beijing, China, shengxin2004@163.com
Mx. Hui Pan, Peking Union Medical College Hospital (CAMS), Beijing, China, panhui2011111@163.com