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Clinical Trial ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurosci. | doi: 10.3389/fnins.2019.01257

Effects of Ten Sessions of High Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS) Add-on Treatment on Impulsivity in Alcohol Use Disorder

 Renee Schluter1*, Ruth J. van Holst1 and  Anna E. Goudriaan1, 2
  • 1Department of Psychiatry, Academic Medical Center, University of Amsterdam, Netherlands
  • 2Arkin (Netherlands), Netherlands

Introduction: Alcohol use disorder is characterized by increased impulsivity, which is multifactorial and can be assessed by tests like the delay discounting, Go-NoGo, and stop signal task. Impulsivity has been related to poor treatment outcomes in substance use disorders, including alcohol use disorder. In order to decrease impulsivity or improve inhibitory control, high frequency transcranial magnetic stimulation (HF-rTMS) has gained interest. Studies applying HF-rTMS over the DLPFC of individuals suffering from alcohol use disorder assessing its effects on impulsivity measures are scarce, and results are inconclusive.
Methods: The current study (registered in The Netherlands Trial Register with trial number 5291: https://www.trialregister.nl/trial/5151) applied ten sessions of HF-rTMS (sixty 10 Hz trains of five seconds at 110% motor threshold) over the right DLPFC of 80 alcohol dependent patients in clinical treatment on ten consecutive workdays. At baseline, halfway and after the HF-rTMS treatment, the delay discounting, Go-NoGo, and stop signal task were assessed.
Results: Ten sessions of HF-rTMS over the right DLPFC versus sham HF-rTMS did not affect performance on the delay discounting, Go-NoGo, and stop signal tasks. A significant effect of age was found for the Go-NoGo task, with higher age associated with better performance. Furthermore, no significant correlations were found between difference scores of task performance and baseline impulsivity or severity of AUD.
Discussion: Results of this study, in combination with other studies using HF-rTMS studies in alcohol and substance use disorder, indicate mixed and inconclusive findings of HF-rTMS on impulsivity. Future studies within patient groups hospitalized at the same department are recommended to consider using a sham coil that mimics the sensations on the scalp of active HF-rTMS and to measure motivation across test sessions.

Keywords: Alcohol use disorder (AUD), Alcohol dependence (AD), Transcranial magnetic stimulation (rTMS), impulsivity, Delay Discounting Task, Go-NoGo Task (GNG), stop signal task, Neuromodulation

Received: 15 Aug 2019; Accepted: 06 Nov 2019.

Copyright: © 2019 Schluter, van Holst and Goudriaan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Renee Schluter, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, 1105, Netherlands, r.s.schluter@amc.uva.nl