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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurosci. | doi: 10.3389/fnins.2019.01261

Changes in capillary hemodynamics and its modulation by exercise in the APP-PS1 Alzheimer mouse model

 XUECONG LU1, 2,  Mohammad Moeini2, 3, Baoqiang Li4, Yuankang Lu1, 2,  Rafat Damseh1, 2,  Philippe Pouliot1, 2,  Eric Thorin2, 5 and  Frederic Lesage1, 2*
  • 1École Polytechnique de Montréal, Canada
  • 2Montreal Heart Institute, Canada
  • 3Department of Chemical Engineering, Faculty of Engineering, Amirkabir University of Technology, Iran
  • 4Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, United States
  • 5Faculty of Medicine, University of Montreal, Canada

Dysfunction in neurovascular coupling that results in a mismatch between cerebral blood flow and neuronal activity has been suggested to play a key role in the pathogenesis of Alzheimer’s disease (AD). Meanwhile, physical exercise is a powerful approach for maintaining cognitive health, and could play a preventive role against the progression of AD. Given the fundamental role of capillaries in the oxygen transport to tissue, our study aimed to characterize changes in capillary hemodynamics with AD and AD supplemented by exercise. Exploiting two-photon microscopy, intrinsic signal optical imaging and magnetic resonance imaging, we found hemodynamic alterations and lower vascular density with AD, reversed by exercise. We further observed that capillary properties were branch order dependent and that stimulation evoked changes were attenuated with AD but increased by exercise. Our study provides novel insights into cerebral microcirculatory disturbances with AD and the modulating role of voluntary exercise on these alterations.

Keywords: Alzheimer’s disease, capillary hemodynamics, voluntary exercise, two-photon imaging, Neural Stimulation

Received: 28 Mar 2019; Accepted: 06 Nov 2019.

Copyright: © 2019 LU, Moeini, Li, Lu, Damseh, Pouliot, Thorin and Lesage. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Frederic Lesage, École Polytechnique de Montréal, Montreal, Canada, frederic.lesage@polymtl.ca