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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurosci. | doi: 10.3389/fnins.2019.01269

Modulation of theta-band local field potential oscillations across brain networks with central thalamic deep brain stimulation to enhance spatial working memory

 Ching-Wen Chang1,  Yu-Chun Lo2,  Sheng-Huang Lin3, 4*,  Shih-Hung Yang5, Hui-Ching Lin1,  Ting-Chun Lin1,  Ssu-Ju Li1, Christine C. Hsieh1,  Vina Ro1, Yueh-Jung Chung1, Yun-Chi Chang1, Chi-Wei Lee1, 2,  Chao-Hung Kuo1, 6, 7 and  You-Yin Chen1*
  • 1National Yang-Ming University, Taiwan
  • 2Taipei Medical University, Taiwan
  • 3Tzu Chi University, Taiwan
  • 4Buddhist Tzu Chi General Hospital, Taiwan
  • 5National Cheng Kung University, Taiwan
  • 6Taipei Veterans General Hospital, Taiwan
  • 7University of Washington, United States

Deep brain stimulation (DBS) is a well-established technique for the treatment of movement and psychiatric disorders through the modulation of neural oscillatory activity and synaptic plasticity. The central thalamus (CT) has been indicated as a potential target for stimulation to enhance memory. However, the mechanisms underlying local field potential (LFP) oscillations and memory enhancement by CT-DBS remain unknown.
In this study, we used CT-DBS to investigate the mechanisms underlying the changes in oscillatory communication between the CT and hippocampus, both of which are involved in spatial working memory. LFPs were recorded from microelectrode array implanted in the CT, dentate gyrus, cornu ammonis region 1, and cornu ammonis region 3. Functional connectivity (FC) strength was assessed by LFP–LFP coherence calculations for these brain regions. In addition, a T-maze behavioral task using a rat model was performed to assess the performance of spatial working memory. In DBS group, our results revealed that theta oscillations significantly increased in the CT and hippocampus compared with that in sham controls. As indicated by coherence, the FC between the CT and hippocampus significantly increased in the theta band after CT-DBS. Moreover, Western blotting showed that the protein expressions of the dopamine D1 and α4-nicotinic acetylcholine receptors were enhanced, whereas that of the dopamine D2 receptor decreased in the DBS group.
In conclusion, the use of CT-DBS resulted in elevated theta oscillations, increased FC between the CT and hippocampus, and altered synaptic plasticity in the hippocampus, suggesting that CT-DBS is an effective approach for improving spatial working memory.

Keywords: Central thalamus, Deep Brain Stimulation, spatial working memory, synaptic plasticity, hippocampal theta oscillation

Received: 13 Jun 2019; Accepted: 08 Nov 2019.

Copyright: © 2019 Chang, Lo, Lin, Yang, Lin, Lin, Li, Hsieh, Ro, Chung, Chang, Lee, Kuo and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Mx. Sheng-Huang Lin, Tzu Chi University, Hualien City, 97004, Taiwan, shlin355@gmail.com
Mx. You-Yin Chen, National Yang-Ming University, Taipei, 112, Taiwan, irradiance@so-net.net.tw