Impact Factor 3.648 | CiteScore 3.99
More on impact ›

Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurosci. | doi: 10.3389/fnins.2019.01271

High Salt Diet Causes Sleep Fragmentation in Young Drosophila through Circadian Rhythm and Dopaminergic Systems

Jiayu Xie1,  Danfeng Wang2, Shengan Ling1, Guang Yang2,  Yufeng Yang1 and  Wenfeng Chen1*
  • 1Institute of Life Sciences, Fuzhou University, China
  • 2Institute of Applied Ecology, Fujian Agriculture and Forestry University, China

Salt (sodium chloride) is an essential dietary requirement, but excessive consumption has long-term adverse consequences. A high salt diet (HSD) increases the risk of chronic diseases such as cardiovascular conditions and diabetes and is also associated with poor sleep quality. Little is known, however, about the neural circuit mechanisms that mediate HSD-induced sleep changes. In this study, we sought to identify the effects of HSD on Drosophila sleep and related neural circuit mechanisms. Strikingly, we found that HSD causes young Drosophila to exhibit a fragmented sleep phenotype similar to that of normal aging individuals. Importantly, we further showed that HSD slightly impairs circadian rhythms and that the HSD-induced sleep changes are dependent on the circadian rhythm system. In addition, we demonstrated that HSD-induced sleep changes are dopaminergic-system dependent. Together, these results provide insight into how elevated salt in the diet can affect sleep quality.

Keywords: High salt diet, Drosophila, Sleep, Circadian Rhythm, dopaminergic system

Received: 21 Aug 2019; Accepted: 08 Nov 2019.

Copyright: © 2019 Xie, Wang, Ling, Yang, Yang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Wenfeng Chen, Institute of Life Sciences, Fuzhou University, Fuzhou, China, chenwenfeng@fzu.edu.cn