Impact Factor 4.677 | CiteScore 5.4
More on impact ›

ORIGINAL RESEARCH article

Front. Neurosci., 18 September 2020 | https://doi.org/10.3389/fnins.2020.568104

BCIAUT-P300: A Multi-Session and Multi-Subject Benchmark Dataset on Autism for P300-Based Brain-Computer-Interfaces

Marco Simões1,2*†, Davide Borra3*†, Eduardo Santamaría-Vázquez4,5, GBT-UPM5,6, Mayra Bittencourt-Villalpando7, Dominik Krzemiński8, Aleksandar Miladinović9, Neural_Engineering_Group10,11, Thomas Schmid12, Haifeng Zhao13, Carlos Amaral1, Bruno Direito1, Jorge Henriques2, Paulo Carvalho2 and Miguel Castelo-Branco1*
  • 1Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute of Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Coimbra, Portugal
  • 2Centre for Informatics and Systems (CISUC), Department of Informatics Engineering, University of Coimbra, Coimbra, Portugal
  • 3Department of Electrical, Electronic and Information Engineering “Guglielmo Marconi” (DEI), University of Bologna, Cesena, Italy
  • 4Grupo de Ingeniería Biomédica, Universidad de Valladolid, Valladolid, Spain
  • 5Centro de Investigación Biomédica en Red, Biomateriales y Nanomedicina, Madrid, Spain
  • 6Biomedical Engineering and Telemedicine Centre, ETSI Telecomunicación, Center for Biomedical Technology, Universidad Politécnica de Madrid, Madrid, Spain
  • 7Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
  • 8CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom
  • 9Department of Engineering and Architecture, University of Trieste, Trieste, Italy
  • 10Department of Biosciences and Bioengineering, Indian Institute of Technology, Guwahati, India
  • 11Data Science Research Group, School of Computing, University of Kent, Chatham, United Kingdom
  • 12Machine Learning Group, Universität Leipzig, Leipzig, Germany
  • 13The University of Sydney, Camperdown, NSW, Australia

There is a lack of multi-session P300 datasets for Brain-Computer Interfaces (BCI). Publicly available datasets are usually limited by small number of participants with few BCI sessions. In this sense, the lack of large, comprehensive datasets with various individuals and multiple sessions has limited advances in the development of more effective data processing and analysis methods for BCI systems. This is particularly evident to explore the feasibility of deep learning methods that require large datasets. Here we present the BCIAUT-P300 dataset, containing 15 autism spectrum disorder individuals undergoing 7 sessions of P300-based BCI joint-attention training, for a total of 105 sessions. The dataset was used for the 2019 IFMBE Scientific Challenge organized during MEDICON 2019 where, in two phases, teams from all over the world tried to achieve the best possible object-detection accuracy based on the P300 signals. This paper presents the characteristics of the dataset and the approaches followed by the 9 finalist teams during the competition. The winner obtained an average accuracy of 92.3% with a convolutional neural network based on EEGNet. The dataset is now publicly released and stands as a benchmark for future P300-based BCI algorithms based on multiple session data.

Introduction

A Brain-Computer Interface (BCI) is a system that provides a direct communication between the brain and a computer or external device (Wolpaw and Winter Wolpaw, 2012). In short, it must interpret brain activity and translate it into commands that can be used to control devices or programs, from prosthesis, orthosis, wheelchairs and other robots to a mouse or a keyboard in a controlled computer environment (Bamdad et al., 2015; Chaudhary et al., 2016; McFarland and Wolpaw, 2017). Different types of neuroimaging techniques can be used to implement BCIs, i.e., electroencephalography (EEG), magnetoencephalography (MEG), functional Magnetic Resonance Imaging (fMRI), functional Near-Infrared Spectroscopy (fNIRS), among others (Zou et al., 2019). The most common modality is the EEG, since it provides a portable, inexpensive, non-invasive solution to measure brain activity with high temporal resolution (Sitaram et al., 2007; Bhattacharyya et al., 2017; Deshpande et al., 2017; Zou et al., 2019).

There are several approaches to generate brain signals that can be interpreted and transformed into commands by the BCIs, namely event-related potentials (the most prominent being the P300), steady-state visual evoked potentials (SSVEP) or event-related synchronization/desynchronization (ERS/D) through mental imagery. The P300 approach, first attempted by Farwell and Donchin in the 80s (Farwell and Donchin, 1988), uses an oddball paradigm where an infrequent stimulus of interest is presented in a sequence of frequent stimuli of non-interest. With this paradigm, a positive deflection of the EEG measured in the central and posterior parts of the scalp is observed approximately around 300 ms after the infrequent stimulus of interest is presented (Guo et al., 2019; Riggins and Scott, 2019). The most common application of P300-based BCIs is the speller, where a matrix of letters flashing at different times is presented to the user. An infrequent event occurs due to selective attention to a specific target letter. Thus, a P300 potential is elicited whenever the letter the user is paying attention to flashes, and so the target letter can be identified by a P300 detection algorithm and then transmitted. The use-cases of P300-based BCIs have greatly increased over the past years, from steering a wheelchair (Lopes et al., 2016) to composing music (Pinegger et al., 2017).

Despite the wide range of applications, there are still many challenges facing P300-based BCIs to be used more broadly. Achieving portable and practical BCIs that are easy to setup and fast to calibrate is currently a research line of big interest, since it would favorably help the adoption of this new technology in everyday settings (Amaral et al., 2017; Nakanishi et al., 2019; Zou et al., 2019). However, different issues causing low robustness and reliability should be addressed for these systems to be used in real life. Indeed, often low performance is obtained by BCI models, even in laboratory conditions. The noise sensitivity, non-linearity and non-stationarity characteristics of EEG signals represent critical challenges since these properties depend both on the subject and the environment (Yger et al., 2017). As a consequence of non-stationarity, shifts in EEG signals across trials and sessions occur. Therefore, robust feature extraction techniques are needed to overcome these perturbations on the signals (Raza et al., 2019). Moreover, inter-subject variability, due to anatomical and physiological differences among subjects, also represents an important challenge since it hinders the design of participant-agnostic BCIs. Due to these main challenges (intra- and inter-subject variabilities), most BCIs require time-consuming calibrations to maximize their performance, which makes the creation of one-model-fits-all solutions difficult (Saha and Baumert, 2020).

Nevertheless, the methods used for correctly identifying P300 signals have improved in the last years (Lotte et al., 2018). Traditional decoding algorithms rely on separate feature extraction and classification steps. Commonly used P300 features are based on temporal, time-frequency and spatial domains (Demiralp et al., 2001; Bostanov and Kotchoubey, 2006; Agapov et al., 2016), while Linear Discriminant Analysis (LDA), Support Vector Machine (SVM) and Multi-Layer Perceptron (MLP) are the most prominent classifiers used in P300-based BCI approaches. Some examples of recent improvements over traditional methods are the use of Riemannian geometry (Korczowski et al., 2015) or weightless neural networks (Simões et al., 2019). Recently, deep learning techniques were transposed from the computer vision (LeCun et al., 2015) to the EEG decoding field. Among these new solutions, Convolutional Neural Networks (CNN) and CNNs including recurrent layers - such as Long Short-Term Memories (LSTM) - on top of the convolutional extractor were used (CNN-LSTM) (Craik et al., 2019). A key property of these algorithms is that they automatically learn the relevant features for a given task (i.e., the features are learned from the input data without any a priori feature extraction and selection) and finalize the target decoding task in an end-to-end fashion (i.e., without separating these steps). Nevertheless, these approaches pose some challenges: they require many hyper-parameters to be tuned (e.g., number of layers, number of kernels, etc.), they introduce a large number of parameters to be optimized during training (which are also difficult to interpret once trained) and thus, require the use of large datasets to achieve state-of-the-art decoding performance (Lawhern et al., 2018; Craik et al., 2019; Zhang et al., 2019). However, few datasets can be found in the literature matching this last requirement.

To evaluate the efficacy of new methods, authors need to compare their results with current state-of-the-art approaches. One viable approach is to implement both their method and established reference methods and apply all of them to the data of interest. Another option is to use benchmark datasets. Benchmark datasets are publicly available data usually launched in competition events where teams have the same information to start with and try to achieve the best possible result with their methods (Rakotomamonjy and Guigue, 2008). These competitions tend to disclose these datasets afterward, allowing both teams and other researchers to continue developing their methods and publish results that are comparable between them, if researchers recreate the original competition conditions on their attempts. Thus, these datasets provide a common ground for the research areas to assess their methods and improve the state-of-the-art.

One important contributor in this field has been the Berlin Brain-Computer Interface (BBCI) group through the organization of BCI competitions1 (Sajda et al., 2003; Blankertz et al., 2004, 2006; Tangermann et al., 2012). The corresponding datasets have been extensively explored and helped significantly the improvement of methods throughout the years (Lotte et al., 2007, 2018). Nevertheless, those datasets were limited in terms of subjects and sessions-per-subject, thus constraining the development of methods highly dependent on multi-session data.

In the scope of the XV Mediterranean Conference in 2019, the International Federation of Medical and Biological Engineering (IFMBE) launched a scientific competition based on a multi-session dataset of P300-based BCI intervention for young adults with autism spectrum disorder (ASD) (Amaral et al., 2018). This intervention was aimed at the rehabilitation of joint-attention, a core developmental skill that is altered in ASD and impacts other skills like language development (Adamson et al., 2019). Joint-attention refers to the ability of following social attentional cues of other people, so one’s attention can be directed by the interlocutor to an external object or event of interest. Amaral et al. (2017) developed an interventional BCI based on P300 signals that uses a virtual environment with a virtual human character and several objects of interest to train the ability of participants to follow the cues of the virtual character to the objects. That system was validated in an interventional pilot study (Amaral et al., 2018) where 15 ASD individuals underwent 7 training sessions with this system. The database resulting from that interventional study supported the 2019 IFMBE scientific challenge and is now made public to the scientific community at https://www.kaggle.com/disbeat/bciaut-p300 (doi: 10.34740/kaggle/dsv/1375326). This paper describes the challenge and corresponding dataset, summarizes the approaches by the competing teams and draws some conclusions from them, challenging the BCI research community to improve the current best performances achieved by the participating teams.

Materials and Methods

Experiment Description

Overview of the P300-Based BCI System

The BCI system is composed mainly by two modules: data acquisition module and stimuli presentation module. For the data acquisition module, we used the g.Nautilus system (g.tec medical engineering GmbH, Austria) to record EEG data from 8 active electrodes positioned at C3, Cz, C4, CPz, P3, Pz, P4, POz locations. The reference electrode was placed at the right ear and the ground electrode at AFz location. Sampling rate was set to 250 Hz and data were acquired notch-filtered at 50 Hz and passband-filtered between 2 and 30 Hz. As for the stimuli presentation module, we used the Vizard toolkit to create and display a virtual environment consisting of a bedroom with common type of furniture (shelves, a bed, a table, a chair, and a dresser) and objects (frames, books, lights, a printer, a radio, a ball, a door, a window, and a laptop), as shown in Figure 1. The objects used as stimuli throughout the experiment (and their respective labels) were: 1. books on a shelf, 2. a radio on top of a dresser, 3. a printer on a shelf, 4. a laptop on a table, 5. a ball on the ground, 6. a corkboard on the wall, 7. a wooden plane hanging from the ceiling, and 8. a picture on the wall. The virtual environment was presented via the Oculus Rift Development Kit 2 headset (from Oculus VR).

FIGURE 1
www.frontiersin.org

Figure 1. Snapshot of the virtual environment, showing the scenario, the virtual avatar and the objects for joint-attention targets.

Each block consists of the user trying to identify one of the objects as the target. For that, K runs are repeated. One run is composed by a single flash of each object once for 100 ms at different times and random order, with an Inter-Stimulus Interval (ISI) of 200 ms. Figure 2 provides a schematic for this structure.

FIGURE 2
www.frontiersin.org

Figure 2. Structure of the paradigm with its subdivisions in blocks, runs and events. (A) Structure of the blocks: each block is used to identify a single target object and is composed by K runs. (B) Structure of the runs: each run is composed by 8 events, each consisting of the flashing of one of the objects. (C) Structure of an event: it consists of the flashing of the corresponding object by 100 ms, followed by an interval of 200 ms.

BCI Session Flow

Fifteen participants performed 7 identical training sessions in different days, the first four on a weekly basis and the last three on a monthly basis. Each training session was divided in two parts: calibration and online phase. Data from calibration and online phases were named in the dataset as train and test data, respectively.

The calibration phase was composed of 20 blocks, each block containing 10 runs. Because we used 10 runs per block, a total of 200 target P300 signals and 1400 non-target signals were acquired at this phase. With these data, the session-specific classifiers were trained for the online phase and the number of runs per block (K) to use on the online phase was defined. K was defined during the online sessions of the clinical trial as the minimum number of runs for which the classifier achieved an accuracy above 80%, in the calibration data.

Regarding the online phase, 50 blocks were taken for each participant using K runs per block. The value of K varied between subjects and sessions, since it was an output of the calibration phase, ranging from 3 to 10.

Dataset Structure and Contents

The dataset folder structure is organized by subjects, with a folder for each subject named SBJXX, with XX varying from 01 to 15. Within each subject folder there is a set of folders containing the data from each session, named SYY, with YY varying from 01 to 07. Each session folder contains a separate folder for the training and testing data, named Train and Test, respectively. The structure and the contents of train and test folders of each session are described in Box 1.

BOX 1. Dataset Folder Structure.

SBJ01\

SBJ02\

..

SBJXX\

             S01\

             S02\

..

             SYY\

                         Train\

                         Test\

Train folder

trainData.mat – Data from the calibration phase, structured as [channels x epoch x event], epoch corresponding to the data samples from −200 ms to 1000 ms relative to the event stimulus onset (epoch length of 1200 ms; 300 data samples).

trainEvents.txt – One label per line (from 1 to 8), corresponding to the order of the flashed objects.

trainTargets.txt – 1 or 0 per line, indicating if the flashed object was the target or not, respectively.

trainLabels.txt – Label of the target object per line (from 1 to 8), one for each block.

Test folder

testData.mat – Data from the online phase, in the same structure as the train data.

testEvents.txt – One label per line (from 1 to 8), corresponding to the order of the flashed objects.

testTargets.txt – 1 or 0 per line, indicating if the flashed object was the target or not, respectively.

testLabels.txt – Label of the target object per line (from 1 to 8), one for each block.

runs_per_block.txt – File containing only one number, corresponding to the number of runs per block used in the online phase (from 3 to 10).

The number of epochs corresponds to # events per run # runs per block # blocks. For the training data, it represents 8 events per run 10 runs per block 20 blocks = 1600 epochs. As for the test data, since the number of runs varies between sessions, the number of epochs varies in consequence, in a total of 8 events per run K runs per block 50 blocks = 400 K epochs.

The channels’ order in the data matrices is C3, Cz, C4, CPz, P3, Pz, P4, POz. The first sample of each epoch corresponds to the time −200 ms relative to the stimulus onset and the last sample to corresponds to the time 996 ms after the stimulus onset (the last sample < 1000 ms), with a sampling rate of 250 Hz, for a total of 300 samples.

Challenge Structure

For the 2019 IFMBE Scientific Challenge, teams were asked to maximize the P300-based object detection accuracy for the 7 sessions of the 15 ASD participants of the BCIAUT clinical trial. For each session, a train and test set were created, without disclosing the true labels of the test sets. The challenge was divided into two phases with a different number of attempts per phase (Table 1). For phase I, sessions 1–3 were provided, without the test labels. At the end of phase I, the true test labels of those three sessions were made available to the participants along with the remaining 4 sessions (4–7), the latter without the true test labels (phase II). This way, teams could use the true labels of the first three sessions to improve their classifiers, if working with multi-session data. Teams were allowed to submit 5 attempts during phase I and 10 attempts during phase II. The best submission of each team throughout the allowed attempts on each phase was used to rank the teams. The complete dataset (including all true labels) is now available at https://www.kaggle.com/disbeat/bciaut-p300 (doi: 10.34740/kaggle/dsv/1375326).

TABLE 1
www.frontiersin.org

Table 1. Timetable and number of attempts for the two phases of the competition.

Submissions and Approaches

Fourteen teams participated in phase I of the competition, while 9 teams participated in phase II and concluded the challenge. The results shown in this manuscript refer to the phase II of the competition. The performance metric used to compare the performance of contesting teams was the target object detection accuracy, computed as the ratio between the number of correct predicted blocks and the total number of blocks to decode. Based on the average target object accuracy across subjects and sessions, the approaches proposed by each team were ranked up.

The following list of IDs reflects the final ranking of the competition:

ID-1: DB, Silvia Fantozzi and Elisa Magosso (Borra et al., 2020a).

ID-2: Eduardo Santamaría-Vázquez, Víctor Martínez-Cagigal, Javier Gomez-Pilar and Roberto Hornero (Santamaría-Vázquez et al., 2020).

ID-3: Lucia de Arancibia, Patricia Sánchez-González, Enrique J. Gómez, M. Elena Hernando and Ignacio Oropesa (de Arancibia et al., 2020).

ID-4: MB-V and Natasha M. Maurits (Bittencourt-Villalpando and Maurits, 2020).

ID-5: DK, Sebastian Michelmann, Matthias Treder and Lorena Santamaria (Krzemiński et al., 2020).

ID-6: AM, Miloš Ajćević, Giulia Silveri, Gaia Ciacchi, Giulietta Morra, Joanna Jarmolowska, Piero Paolo Battaglini and Agostino Accardo (Miladinović et al., 2020).

ID-7: Bipra Chatterjee, Ramaswamy Palaniappan and Cota Navin Gupta (Chatterjee et al., 2020).

ID-8: V. Sophie Adama, Schindler Benjamin and TS (Adama et al., 2020).

ID-9: HZ, Shiduo Yu, Joseph Prinable, Alistair McEwan and Petra Karlsson (Zhao et al., 2020).

For each team, a brief description of the proposed methodology is reported:

ID-1: Epochs were extracted between −100–1000 ms, and the signals were downsampled to 128 Hz. The decoding solution was based on a CNN performing classification at the level of single trial (EEG response to a single stimulus, without averaging). The input was a 2-D representation composed by the EEG channels along one dimension (spatial dimension) and time steps along the other dimension (temporal dimension). The CNN was an adaptation of EEGNet (Lawhern et al., 2018) trained to discriminate between P300 and non-P300 classes. In this CNN design, depthwise and pointwise convolutions are used to keep the number of trainable parameters limited. The architecture in its fundamental subnetworks and main connections between neurons is displayed in Figure 3. Furthermore, a detailed description of these subnetworks including the main hyper-parameters, output activation shapes and number of trainable parameters introduced is reported in Table 2. The CNN is composed by 3 main subnetworks (here labeled as A, B, C), performing different operations on the input. These include a temporal and spatial feature extractor (Figure 3A) that learns meaningful temporal and spatial filters, a summary feature extractor (Figure 3B) that learns to extract temporal summaries for each feature map of the subnetwork A individually; and a classification module (Figure 3C) that finalizes the classification task based on the output of the subnetwork B. The obtained single-trial probabilities were then averaged together across runs related to a specific object belonging to each block, and then the object with maximum average probability was selected, solving the target 8-way classification task. Different intra-subject training strategies were explored, including inter-session (i.e., training subject-specific classifiers) and intra-session (i.e., training session-specific classifiers) training strategies. The top-performing solution of ID-1 was the one adopting a subject-wise inter-session strategy. The code of the CNN and the weights of the trained models are available at https://github.com/ddavidebb/IFMBE2019Challenge-BCIAUT-P300.

FIGURE 3
www.frontiersin.org

Figure 3. Architecture schematization of the winning solution ID-1 based on EEGNet. The represented shapes correspond to the output of each layer. Green lines represent convolutional connections, red lines pooling connections, and blue lines dense connections. The CNN is composed by a temporal and spatial feature extractor (A), a summary feature extractor (B) and a classification module (C).

TABLE 2
www.frontiersin.org

Table 2. Architecture design inspired from EEGNet and adopted in ID-1.

ID-2: EEG signals were epoched between 0–1000 ms, applying a baseline (−200-0 ms) normalization. The input representation is the same as in ID-1. The task was faced as a 2-way classification decoding P300 and non-P300 classes for each trial adopting an adaptation of the CNN proposed by Manor et al. (Manor and Geva, 2015), a CNN-LSTM and a CNN-BLSTM. Furthermore, these deep learning architectures were compared with a more traditional machine learning pipeline including SWLDA. The top-performing algorithm proposed by ID-2 was CNN-BLSTM. This network was composed of one convolutional layer 1-D that extracts spatio-temporal patterns on the input, two bidirectional LSTM layers and one dense layer. The single-trial probabilities were averaged to obtain object-level probabilities as in ID-1. An intra-subject and inter-session training strategy was adopted, training subject-specific classifiers. The code of the models and the weights of the trained models are available at https://github.com/esantamariavazquez/IFMBE2019Challenge-BCIAUT-P300.

ID-3: EEG signals related to a specific object were averaged across trials of the same block. Feature extraction was based on temporal and time-frequency parameters. Temporal features were extracted in epochs between 0–1000 ms by downsampling the signals with a decimation factor of 10. In addition to temporal features, features based on continuous wavelet transform (CWT) were extracted from epochs between 200–712 ms. The t-CWT was computed based on a Mexican Hat wavelet on scales corresponding to the delta (0.5–4 Hz) and theta (4–8 Hz) bands (Demiralp et al., 2001; Bostanov and Kotchoubey, 2006). These temporal and time-scale features were concatenated across channels in a single vector. Principal component analysis (PCA) was applied for feature dimensionality reduction, which resulted in a final vector of 120 features. A comparison of different combinations of linear and non-linear machine learning approaches was performed. More specifically, linear discriminant analysis (LDA) and support vector machines with linear kernel (LSVM), and a more complex support vector machine with radial kernel (RSVM) were employed. The object whose corresponding signals yielded a higher probability of containing a P300 event was chosen as predicted target object of the block. In addition, the effect on the accuracy of the number of EEG events averaged was studied. An inter-session training strategy was adopted, comparing both subject-specific and inter-subject classifiers, as well as the use of oversampling and boosting techniques to account for class imbalance. LDA outperformed the other classifiers and was used to classify the target object. Best results were obtained for > 3 events averaged. Training subject-specific classifiers yielded the best performance. Oversampling and boosting did not improve the final performance of the classifiers. The developed code and trained models are available at: http://dev.gbt.tfo.upm.es/ioropesa/ifmbe-scientific-challenge-competition—detection-of-p300/tree/master.

ID-4: The approach consisted of the adaptation and parameter optimization of an SVM-based algorithm that was previously developed for a 4-choice BCI (Bittencourt-Villalpando and Maurits, 2018) for target identification. During the first phase of the challenge, the original algorithm was adapted for 8 choices and the pre-processing parameters were defined as follows. First, temporal features were extracted in epochs between 0–1000 ms following each event onset and all channels were concatenated in a single feature vector per event for each participant and session. Then, feature vectors containing EEG signals from target events were pseudo-randomly averaged across blocks belonging to the same session for noise reduction. During the second phase of the challenge, an intra-subject and intra-session training strategy was developed, augmenting the dataset with other sessions’ signals, and artificially increasing the number of targets per session by adapting the pseudorandom averaging procedure. Eight parameters related to data augmentation and SVM input parameters were optimized throughout the 9 initial attempts and then compared in terms of accuracy. The parameters’ description and settings per attempt are detailed in Bittencourt-Villalpando and Maurits (2020). In the last attempt, the best performing parameter setting was selected, resulting in a customized solution per participant and per session.

ID-5: This solution exploited Riemannian framework for EEG signal decoding (Korczowski et al., 2015). The approach was computationally efficient and recently outperformed other common state-of-the-art approaches (Barachant et al., 2010). The Riemannian framework was combined with the ensemble learning. The idea was to build upon many “weak” (under-performing) classifiers and then combine their outcomes to improve the performance of the final model. The ensemble of 8 different data features was constructed by combining 2 different band-pass filters (1–20 Hz or 1–8 Hz), 2 trial lengths (from −200 to 1000 ms or from 0 to 600 ms) and 3 different subsets of electrodes (all, central or posterior only electrodes). Then, the ERP prototypes were created by calculating the ERP for each channel. Next, the regularized covariance matrices of a single trial concatenated with the prototype were computed and the resultant matrices were projected into the tangent space of a reference matrix. Fisher Geodesic Discriminant Analysis (FGDA) was used to project the matrices to a lower-dimensional discriminative subspace. The resultant projections were flattened to vectors and used as the features to the ensemble learning algorithm comprising 400 LDA classifiers. The output probability was aggregated across trials belonging to each object to decode the target per each block. An intra-subject and intra-session training strategy was adopted. The developed code is available at https://github.com/dokato/bci-challange.

ID-6: The windows mean approach was used to obtain the temporal features on each trial. These were computed for each electrode on 50 ms windows without overlap from 100–1000 ms. Bayesian logistic regression with automatic relevance determination (VB-ARD) (Drugowitsch, 2013) was used to classify the P300 event on each trial. The method has an advantage over other regularization techniques which need a separate validation set to eliminate irrelevant features. Besides, this approach generates a posterior distribution enabling the authors to model the varying-intercept sparse feature model. The modeling applied in this approach is similar to the one proposed by Bishop (2006) with a variation of Automatic Relevance Determination (ARD) that instead of using type-II maximum likelihood (MacKay, 1992), applies full Bayesian treatment (Drugowitsch, 2013). The primary generative model matches the one employed in Bishop (2006), and the prior is selected to be non-informative, modeled by a conjugate Gamma distribution (Drugowitsch, 2013). This makes the model parameter-free and easy to use without deep knowledge in the data science domain. The advantage of this methodology is that obtained distribution allows the authors to find the inverse of the predictors’ covariance matrix (precision matrix) and apply Automatic Relevance Determination (ARD) that assigns an individual hyper-prior to each regression coefficient separately determining their relevance and produces for each trial a class-belonging probability. Lastly, single-trial probabilities were averaged together across trials for each object belonging and the one with maximum average probability was selected. In this method, an intra-subject and intra-session training strategy was performed. The demo code is available at https://github.com/miladinovic/BCILabTS under subfolder userscripts.

ID-7: Whole signals were used (−200–1000 ms) and the pre-stimulus mean (−200-0 ms) was removed. Signals were filtered between 2–12 Hz and the filtered signals were downsampled 10-times. Then, these downsampled electrode signals were normalized epoch-wise in the range −100–1000 ms. These temporal features were used to classify the P300 event for each trial with BLDA, RUSBoost and CNN. The best performing classifier for each subject was used (subject-specific classifier). Then, a majority voting was done to determine the target object within each specific block. An intra-subject and inter-session training strategy was performed.

ID-8: EEG signals were averaged across trials related to a specific object belonging to each block. Temporal features were extracted for each electrode by averaging for each time window from 200–450 ms and decimating the output with a factor of 12. In addition, Pearson’s correlation coefficient was computed for each electrode between the time window of interest and the time window preceding stimulus presentation (−200-0 ms). These temporal features and correlation coefficients were concatenated across channels in a single feature vector. An inter-subject and inter-session training strategy was performed, by which a variety of competing supervised learning techniques (decision tree, random forest, SVM, MLP) were trained to classify the target object within each block. From those, MLP performed best on the given data.

ID-9: Epochs were extracted from 0–600 ms. An additional 20 Hz low-pass filter was applied to the original data. In addition, a custom filter was designed to address each subject- and session-specific noise features. The temporal features were selected using a linear support vector regression as a pre-selector for features in the data. A comparison between linear and non-linear methods was performed, using SVM, LDA, 1D 4-layer CNN, 1-layer LSTM. LDA was the top-performing classification algorithm for ID-9 and was used to classify the P300 event for each trial. Then, the label that appeared most times within each block was the target object to decode. An intra-subject and intra-session training strategy was adopted. The code is available at https://github.com/hyphenzhao/MEDICON2019ScientificChallenge.

A summary of the top-performing method of each team adopted for the challenge is shown in Table 3.

TABLE 3
www.frontiersin.org

Table 3. Summary of the best-performing algorithm of each team developed for the challenge.

Statistical Analysis

For each team, the best-performing solution proposed among the phase II attempts – in terms of target object accuracy averaged across subjects and sessions – was selected for analysis and the algorithms were then ranked up based on this average score. Furthermore, the metrics scored by algorithms ID-2:9 were compared with the winning algorithm (ID-1) using Wilcoxon signed-rank tests. To correct for multiple tests, a false discovery rate correction at 5% using the Benjamini-Hochberg procedure (Benjamini and Hochberg, 1995) was applied and the corrected p-values are reported.

Results

In Tables 4, 5 the accuracies of the proposed approaches are shown, describing the decoding variability across subjects and recording sessions. In particular, Table 4 reports for each subject the average target object accuracy across sessions (i.e., performance at the level of single subjects), while Table 5 reports for each session the average target object accuracy across subjects (i.e., performance at the level of single session).

TABLE 4
www.frontiersin.org

Table 4. Performance at the level of single subject as represented by the average target object accuracies of the best approach proposed by each team.

TABLE 5
www.frontiersin.org

Table 5. Performance at the level of single session as represented by average target object accuracies across subjects of the best approach proposed by each team.

Averaging across sessions and across subjects, ID-1 significantly outperformed the other approaches, with less variability across subjects and sessions. Looking at the performance at the level of subjects, ID-1 provided the best performance metric for 14 out of 15 subjects (for subject #4, ID-2 provided a top-performance across the proposed solutions too), while ID-3 provided the best performance metric for 1 out of 15 subjects (subject #14).

Averaging across subjects, ID-1 significantly outperformed the other approaches within each recording session, with less variability across subjects and providing an average performance above 90% for all the phase II sessions.

Discussion

In this study, a large multi-session and multi-subject dataset acquired during a P300-based BCI intervention for young adults with ASD was presented. The evolution and the practical application of deep learning solutions for EEG decoding depend on the availability of large multi-subject datasets. Furthermore, the lack of multi-session datasets hinders the design of reliable algorithms across recording sessions. Thus, the described dataset represents a multi-session collection of signals that can be used as a benchmark to design accurate and reliable data-hungry algorithms, such as deep learning solutions, for P300 decoding tasks.

In fact, the richness of the dataset enabled the use of deep learning approaches in the context of the competition. Among the proposed algorithms, a deep learning solution based on a lightweight CNN (see ID-1 in Section “Submissions and Approaches”) outperformed both a CNN-BLSTM (p = 0.001, across subjects and sessions, see Table 4, ID-2) and more traditional machine-learning solutions (p < 0.001, across subjects and sessions, see Table 4). Furthermore, this was found also for single session recordings (p < 0.005 when comparing ID-1 with other solutions, see Table 5), with average metrics above 90% (far above the chance level of 12.5%). The best non-deep learning solution adopted temporal and CWT features, alongside with PCA for dimensionality reduction and LDA for classification (see ID-3 in Section “Submissions and Approaches”). The training strategies performed in the approaches ID-1:3 were both intra-subject and inter-session. In particular for the winning solution, from the experiments between inter-session and intra-session trainings performed by ID-1, better results were found using all the session signals during the optimization.

When using deep learning approaches with EEG signals, the input representation and the design of spatio-temporal convolutions is not trivial and need to be addressed. Regarding the input representation, the time series are related to electrodes placed on a 3D surface. Typically, EEG signals can be represented in three different ways to feed the input layer of a neural network (Lawhern et al., 2018):

a. Using the original representation of all the available electrode signals to design a 2D representation where EEG channels are reported along one dimension (spatial dimension) and time steps along the other dimension (temporal dimension).

b. Using a transformed representation (e.g., time-frequency decomposition) of all the available electrodes.

c. Using a representation as in (b) with a subset of electrodes.

Among these representations, the first one is preferred since a representation like (b) generally increases the dimensionality (Lawhern et al., 2018), leading to more trainable parameters and, thus, to the need of more data or an increased regularization. Furthermore, several hyper-parameters are introduced depending on the transformation applied. Lastly, representations like (c) share the main disadvantages of (b) with an additional needing of a priori knowledge about the more relevant subset of electrodes to choose. Therefore, representations that respect the scheme (a) are a good compromise between input dimensionality and capability to learn more general EEG features on all the electrode signals (Lawhern et al., 2018). Among the best-performing solutions in this competition, ID-1 and ID-2 adopted the first input representation scheme.

Regarding the design of spatio-temporal convolutions, depending on the information processing in the convolutional module, three different solutions can be designed starting from the input layer:

i. The temporal filtering is performed at first and then the spatial filtering.

ii. The spatial filtering is performed at first and then the temporal filtering.

iii. Mixed spatio-temporal filtering.

The CNN adopted by ID-1 used the convolutions ordering as in (i), while the CNN-BLSTM adopted by ID-2 as in (iii). Furthermore, among the solutions proposed by ID-2, there was a CNN based on Manor and Geva (2015) adopting a convolution ordering as in (ii). Thus, in this competition, the solutions based on convolution ordering as in (i) outperformed the solutions following (ii) and (iii) designs.

In addition, the layers of the neural network need to be carefully designed to keep control the number of trainable parameters and thus, to avoid overfitting when handling a limited collection of training signals. To this aim, architectures like EEGNet (Lawhern et al., 2018) were proposed including optimized convolutions, such as depthwise and separable convolutions (Chollet, 2016). The CNN adapted in ID-1 was inspired from Lawhern et al. (2018) and introduced only 1386 trainable parameters, while the CNN-BLSTM designed by ID-2 introduced 10113 parameters. Lastly, among the solutions proposed by ID-2 (different from the best-performing algorithm of ID-2), a CNN based on Manor et al. (Manor and Geva, 2015) introduced 37428963 parameters. Therefore, in this competition the use of a lightweight architecture to solve the target P300 decoding task was beneficial. This result is in line with the recent growth of interest in the design of optimized layers in CNNs for EEG decoding as proposed by Zhao et al. (2019) and Borra et al. (2020b).

The BCIAUT-P300 dataset presents rare characteristics which reinforce its potentialities to work as a benchmark for P300-based BCI methods: 1) the multi-subject dimension, with 15 participants undergoing the same procedure, enable the possibility of developing inter-subject methods for generalized off-the-shelf applications; 2) the multi-session dimension, since each subject repeated the same training task 7 times in different weeks, enables the study of stability and reliability of subject-specific BCI methods throughout time, and even the inclusion of reinforcement learning strategies by approaching the sessions gradually; and 3) the ASD clinical dimension, since real-life BCI applications on ASD patients pose several challenges, this dataset provide a test bench for data quality and artifactual EEG data on ASD population that new projects can use to validate its models before approaching the clinical patients directly.

Conclusion

This paper presented the BCIAUT-P300 dataset which combines multi-session and multi-subject data of 15 ASD participants using a P300-based BCI for training joint-attention skills. The dataset was used on the IFMBE scientific competition where 9 teams from around the world reach the final phase and presented their methods, which were briefly presented here. Overall, deep learning methods were able to overcome the more traditional machine learning approaches, with the best method obtaining an average accuracy of 92.3%. Future studies should address the multiple dimensions of the dataset to reduce training times while improving accuracy.

Members of the GBT-UPM and Neural_Engineering_Group

GBT-UPM: Lucía de Arancibia, Patricia Sánchez-González, Enrique J. Gómez, M. Elena Hernando, and Ignacio Oropesa.

Neural_Engineering_Group: Bipra Chatterjee, Ramaswamy Palaniappan, and Cota Navin Gupta.

Data Availability Statement

The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found below: https://www.kaggle.com/disbeat/bciaut-p300 (doi: 10.34740/kaggle/dsv/1375326).

Ethics Statement

The studies involving human participants were reviewed and approved by CEIC—Comissão de Ética para a Investigação Clínica (Portuguese Ethics Committee for Clinical Research). Written informed consent to participate in this study was provided by the participants’ legal guardian/next of kin.

Author Contributions

MS organized the challenge, the dataset and partially wrote most of the sections of the document along with DB. DB also performed the statistical analysis. DB, ES-V, GBT-UPM, MB-V, DK, AM, NEG, TS, and HZ wrote the ID-1:9 descriptions, in that order. CA was responsible for the BCI system development and data collection and, along with MS, BD, and JH coordinated the IFMBE Scientific Challenge. PC supervised the IFMBE Scientific Challenge and MC-B was the PI of the BCIAUT clinical trial, providing scientific guidance to all the process. All authors reviewed and made significant contributions to the final document.

Funding

This work was supported by Fundação para a Ciência e[cpsenter]Tecnologia, PAC –286 MEDPERSYST, POCI-01-0145-FEDER- 016428, BIGDATIMAGE, CENTRO-01-0145-FEDER-000016 financed by Centro 2020 FEDER, COMPETE, FCT UID/4950/2020, PTDC/PSI-GER/30852/2017. For Neural Engineering Group: Bipra Chatterjee was funded by MHRD Doctoral Student Scholarship from the Government of India and Cota Navin Gupta’s time was funded by Scheme for Promotion of Academic and Research Collaboration (SPARC Grant), Project Code: P1073.

Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Acknowledgments

The Scientific Challenge is an initiative sponsored by the Health Informatics and eHealth Working Group of the International Federation on Medical and Biological Engineering – IFMBE.

Footnotes

  1. ^ http://www.bbci.de/activities#competition

References

Adama, V. S., Schindler, B., and Schmid, T. (2020). “Using time domain and pearson’s correlation to predict attention focus in autistic spectrum disorder from EEG P300 components,” in XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019, eds J. Henriques, N. Neves, and P. de Carvalho (Cham: Springer), 1890–1893. doi: 10.1007/978-3-030-31635-8_230

CrossRef Full Text | Google Scholar

Adamson, L. B., Bakeman, R., Suma, K., and Robins, D. L. (2019). An expanded view of joint attention: skill, engagement, and language in typical development and autism. Child Dev. 90, e1–e18. doi: 10.1111/cdev.12973

PubMed Abstract | CrossRef Full Text | Google Scholar

Agapov, S. N., Bulanov, V. A., Zakharov, A. V., and Sergeeva, M. S. (2016). Wavelet Algorithm for the Identification of P300 ERP Component. Available online at: http://arxiv.org/abs/1611.00033 (accessed May 10, 2020).

Google Scholar

Amaral, C., Mouga, S., Simões, M., Pereira, H. C., Bernardino, I., Quental, H., et al. (2018). A feasibility clinical trial to improve social attention in autistic spectrum disorder (ASD) using a brain computer interface. Front. Neurosci. 12:477. doi: 10.3389/fnins.2018.00477

PubMed Abstract | CrossRef Full Text | Google Scholar

Amaral, C., Simões, M., Souga, S., Andrade, J., and Castelo-Branco, M. (2017). A novel Brain Computer Interface for classification of social joint attention in autism and comparison of 3 experimental setups: a feasibility study. J. Neurosci. Methods 290, 105–115. doi: 10.1016/j.jneumeth.2017.07.029

PubMed Abstract | CrossRef Full Text | Google Scholar

Bamdad, M., Zarshenas, H., and Auais, M. A. (2015). Application of BCI systems in neurorehabilitation: a scoping review. Disabil. Rehabil. Assist. Technol. 10, 355–364. doi: 10.3109/17483107.2014.961569

PubMed Abstract | CrossRef Full Text | Google Scholar

Barachant, A., Bonnet, S., Congedo, M., and Jutten, C. (2010). “Riemannian geometry applied to BCI classification,” in Latent Variable Analysis and Signal Separation. LVA/ICA 2010. Lecture Notes in Computer Science, eds V. Vigneron, V. Zarzoso, E. Moreau, R. Gribonval, and E. Vincent (Berlin: Springer), 629–636. doi: 10.1007/978-3-642-15995-4_78

CrossRef Full Text | Google Scholar

Benjamini, Y., and Hochberg, Y. (1995). Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B 57, 289–300. doi: 10.1111/j.2517-6161.1995.tb02031.x

CrossRef Full Text | Google Scholar

Bhattacharyya, S., Khasnobish, A., Ghosh, P., Mazumder, A., and Tibarewala, D. N. (2017). “A review on brain imaging techniques for BCI applications,” in Medical Imaging: Concepts, Methodologies, Tools, and Applications, ed. Information Resources Management Association (Pennsylvania: IGI Global), 300–330. doi: 10.4018/978-1-5225-0571-6.ch012

CrossRef Full Text | Google Scholar

Bishop, C. M. (2006). Pattern Recognition and Machine Learning. Cham: Springer.

Google Scholar

Bittencourt-Villalpando, M., and Maurits, N. M. (2018). Stimuli and feature extraction algorithms for brain-computer interfaces: a systematic comparison. IEEE Trans. Neural Syst. Rehabil. Eng. 26, 1669–1679. doi: 10.1109/tnsre.2018.2855801

PubMed Abstract | CrossRef Full Text | Google Scholar

Bittencourt-Villalpando, M., and Maurits, N. M. (2020). “Linear SVM algorithm optimization for an EEG-based brain-computer interface used by high functioning autism spectrum disorder participants,” in XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019, eds J. Henriques, N. Neves, and P. de Carvalho (Cham: Springer), 1875–1884. doi: 10.1007/978-3-030-31635-8_228

CrossRef Full Text | Google Scholar

Blankertz, B., Müller, K. R., Curio, G., Vaughan, T. M., Schalk, G., Wolpaw, J. R., et al. (2004). The BCI competition 2003: progress and perspectives in detection and discrimination of EEG single trials. IEEE Trans. Biomed. Eng. 51, 1044–1051. doi: 10.1109/TBME.2004.826692

PubMed Abstract | CrossRef Full Text | Google Scholar

Blankertz, B., Müller, K. R., Krusienski, D. J., Schalk, G., Wolpaw, J. R., Schlögl, A., et al. (2006). The BCI competition III: validating alternative approaches to actual BCI problems. IEEE Trans. Neural Syst. Rehabil. Eng. 14, 153–159. doi: 10.1109/TNSRE.2006.875642

PubMed Abstract | CrossRef Full Text | Google Scholar

Borra, D., Fantozzi, S., and Magosso, E. (2020a). “Convolutional neural network for a P300 brain-computer interface to improve social attention in autistic spectrum disorder,” in XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019, eds J. Henriques, N. Neves, and P. de Carvalho (Cham: Springer), 1837–1843. doi: 10.1007/978-3-030-31635-8_223

CrossRef Full Text | Google Scholar

Borra, D., Fantozzi, S., and Magosso, E. (2020b). Interpretable and lightweight convolutional neural network for EEG decoding: application to movement execution and imagination. Neural Netw. 129, 55–74. doi: 10.1016/j.neunet.2020.05.032

PubMed Abstract | CrossRef Full Text | Google Scholar

Bostanov, V., and Kotchoubey, B. (2006). The t-CWT: a new ERP detection and quantification method based on the continuous wavelet transform and Student’s t-statistics. Clin. Neurophysiol. 117, 2627–2644. doi: 10.1016/j.clinph.2006.08.012

PubMed Abstract | CrossRef Full Text | Google Scholar

Chatterjee, B., Palaniappan, R., and Gupta, C. N. (2020). “Performance evaluation of manifold algorithms on a P300 paradigm based online BCI dataset,” in XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019, eds J. Henriques, N. Neves, and P. de Carvalho (Cham: Springer), 1894–1898. doi: 10.1007/978-3-030-31635-8_231

CrossRef Full Text | Google Scholar

Chaudhary, U., Birbaumer, N., and Ramos-Murguialday, A. (2016). Brain-computer interfaces for communication and rehabilitation. Nat. Rev. Neurol. 12, 513–525. doi: 10.1038/nrneurol.2016.113

PubMed Abstract | CrossRef Full Text | Google Scholar

Chollet, F. (2016). “Xception: deep learning with depthwise separable convolutions,” in Proceedings of the 2017 IEEE Conf. Comput. Vis. Pattern Recognit.,(Piscataway, NJ: IEEE), 1800–1807.

Google Scholar

Craik, A., He, Y., and Contreras-Vidal, J. L. (2019). Deep learning for electroencephalogram (EEG) classification tasks: a review. J. Neural Eng. 16:031001. doi: 10.1088/1741-2552/ab0ab5

PubMed Abstract | CrossRef Full Text | Google Scholar

de Arancibia, L., Sánchez-González, P., Gómez, E. J., Hernando, M. E., and Oropesa, I. (2020). “Linear vs nonlinear classification of social joint attention in autism using VR P300-based brain computer interfaces,” in XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019, eds J. Henriques, N. Neves, and P. de Carvalho (Cham: Springer), 1869–1874. doi: 10.1007/978-3-030-31635-8_227

CrossRef Full Text | Google Scholar

Demiralp, T., Ademoglu, A., Istefanopulos, Y., Başar-Eroglu, C., and Başar, E. (2001). Wavelet analysis of oddball P300. Int. J. Psychophysiol. 39, 221–227. doi: 10.1016/S0167-8760(00)00143-4

CrossRef Full Text | Google Scholar

Deshpande, G., Rangaprakash, D., Oeding, L., Cichocki, A., and Hu, X. P. (2017). A new generation of brain-computer interfaces driven by discovery of latent EEG-fMRI linkages using tensor decomposition. Front. Neurosci. 11:246. doi: 10.3389/fnins.2017.00246

PubMed Abstract | CrossRef Full Text | Google Scholar

Drugowitsch, J. (2013). Variational Bayesian inference for linear and logistic regression. arXiv [Preprint]. Avaialble at: https://arxiv.org/abs/1310.5438 (accessed May 10, 2020).

Google Scholar

Farwell, L., and Donchin, E. (1988). Talking off the top of your head: toward a mental prosthesis utilizing event-related brain potentials. Electr. Clin. Neurophysiol. 70, 510–523. doi: 10.1016/0013-4694(88)90149-6

CrossRef Full Text | Google Scholar

Guo, M., Jin, J., Jiao, Y., Wang, X., and Cichockia, A. (2019). Investigation of visual stimulus with various colors and the layout for the oddball paradigm in evoked related potential-based brain–computer interface. Front. Comput. Neurosci. 13:24. doi: 10.3389/fncom.2019.00024

PubMed Abstract | CrossRef Full Text | Google Scholar

Korczowski, L., Congedo, M., and Jutten, C. (2015). “Single-trial classification of multi-user P300-based brain-computer interface using riemannian geometry,” in Proceedings of the 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), (Piscataway, NJ: IEEE), 1769–1772.

Google Scholar

Krusienski, D. J., Sellers, E. W., Cabestaing, F., Bayoudh, S., McFarland, D. J., Vaughan, T. M., et al. (2006). A comparison of classification techniques for the P300 Speller. J. Neural Eng. 3:299.

Google Scholar

Krzemiński, D., Michelmann, S., Treder, M., and Santamaria, L. (2020). “Classification of P300 component using a riemannian ensemble approach,” in XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019, eds J. Henriques, N. Neves, and P. de Carvalho (Cham: Springer), 1885–1889. doi: 10.1007/978-3-030-31635-8_229

CrossRef Full Text | Google Scholar

Lawhern, V. J., Solon, A. J., Waytowich, N. R., Gordon, S. M., Hung, C. P., and Lance, B. J. (2018). EEGNet: a compact convolutional neural network for EEG-based brain-computer interfaces. J. Neural Eng. 15:aace8c. doi: 10.1088/1741-2552/aace8c

PubMed Abstract | CrossRef Full Text | Google Scholar

LeCun, Y., Bengio, Y., and Hinton, G. (2015). Deep learning. Nature 521:436.

Google Scholar

Lopes, A. C., Rodrigues, J., Perdigão, J., Pires, G., and Nunes, U. J. (2016). A new hybrid motion planner. IEEE Robot. Autom. Mag. 23, 82–93. doi: 10.1109/MRA.2016.2605403

CrossRef Full Text | Google Scholar

Lotte, F., Bougrain, L., Cichocki, A., Clerc, M., Congedo, M., Rakotomamonjy, A., et al. (2018). A review of classification algorithms for EEG-based brain-computer interfaces: a 10 year update. J. Neural Eng. 15, R1–R13. doi: 10.1088/1741-2552/aab2f2

PubMed Abstract | CrossRef Full Text | Google Scholar

Lotte, F., Congedo, M., Lécuyer, A., Lamarche, F., and Arnaldi, B. (2007). A review of classification algorithms for EEG-based brain-computer interfaces. J. Neural Eng. 4, R1–R13.

Google Scholar

MacKay, D. J. C. (1992). Bayesian interpolation. Neural Comput. 4, 415–447. doi: 10.1162/neco.1992.4.3.415

PubMed Abstract | CrossRef Full Text | Google Scholar

Manor, R., and Geva, A. B. (2015). Convolutional neural network for multi-category rapid serial visual presentation BCI. Front. Comput. Neurosci. 9:146.

Google Scholar

McFarland, D. J., and Wolpaw, J. R. (2017). EEG-based brain–computer interfaces. Curr. Opin. Biomed. Eng. 4, 194–200. doi: 10.1016/j.cobme.2017.11.004

PubMed Abstract | CrossRef Full Text | Google Scholar

Miladinović, A., Ajćević, M., Battaglini, P. P., Silveri, G., Ciacchi, G., Morra, G., et al. (2020). “Slow cortical potential BCI classification using sparse variational bayesian logistic regression with automatic relevance determination,” in Proceedings of the XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019, eds J. Henriques, N. Neves, and P. de Carvalho (Cham: Springer), 1853–1860. doi: 10.1007/978-3-030-31635-8_225

CrossRef Full Text | Google Scholar

Nakanishi, M., Wang, Y.-T., Wei, C.-S., Chiang, K.-J., and Jung, T.-P. (2019). Facilitating calibration in high-speed BCI spellers via leveraging cross-device shared latent responses. IEEE Trans. Biomed. Eng. 67, 1105–1113. doi: 10.1109/tbme.2019.2929745

PubMed Abstract | CrossRef Full Text | Google Scholar

Pinegger, A., Hiebel, H., Wriessnegger, S. C., and Müller-Putz, G. R. (2017). Composing only by thought: novel application of the P300 brain-computer interface. PLoS One 12:e0181584. doi: 10.1371/journal.pone.0181584

PubMed Abstract | CrossRef Full Text | Google Scholar

Rakotomamonjy, A., and Guigue, V. (2008). BCI competition III: dataset II- ensemble of SVMs for BCI P300 speller. IEEE Trans. Biomed. Eng. 55, 1147–1154. doi: 10.1109/TBME.2008.915728

PubMed Abstract | CrossRef Full Text | Google Scholar

Raza, H., Rathee, D., Zhou, S. M., Cecotti, H., and Prasad, G. (2019). Covariate shift estimation based adaptive ensemble learning for handling non-stationarity in motor imagery related EEG-based brain-computer interface. Neurocomputing 343, 154–166. doi: 10.1016/j.neucom.2018.04.087

PubMed Abstract | CrossRef Full Text | Google Scholar

Riggins, T., and Scott, L. S. (2019). P300 development from infancy to adolescence. Psychophysiology 57:e13346. doi: 10.1111/psyp.13346

PubMed Abstract | CrossRef Full Text | Google Scholar

Saha, S., and Baumert, M. (2020). Intra- and inter-subject variability in EEG-based sensorimotor brain computer interface: a review. Front. Comput. Neurosci. 13:87. doi: 10.3389/fncom.2019.00087

PubMed Abstract | CrossRef Full Text | Google Scholar

Sajda, P., Gerson, A., Muller, K.-R., Blankertz, B., and Parra, L. (2003). A data analysis competition to evaluate machine learning algorithms for use in brain-computer interfaces. IEEE Trans. Neural Syst. Rehabil. Eng. 11, 184–185. doi: 10.1109/TNSRE.2003.814453

PubMed Abstract | CrossRef Full Text | Google Scholar

Santamaría-Vázquez, E., Martínez-Cagigal, V., Gomez-Pilar, J., and Hornero, R. (2020). “Deep learning architecture based on the combination of convolutional and recurrent layers for ERP-based brain-computer interfaces,” in XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019, eds J. Henriques, N. Neves, and P. de Carvalho (Cham: Springer), 1844–1852. doi: 10.1007/978-3-030-31635-8_224

CrossRef Full Text | Google Scholar

Simões, M., Amaral, C., França, F., Carvalho, P., and Castelo-Branco, M. (2019). “Applying weightless neural networks to a P300-based brain-computer interface,” in World Congress on Medical Physics and Biomedical Engineering 2018. IFMBE Proceedings, eds L. Lhotska, L. Sukupova, I. Lackoviæ, and G. Ibbott (Singapore: Springer), 113–117. doi: 10.1007/978-981-10-9023-3_20

CrossRef Full Text | Google Scholar

Sitaram, R., Caria, A., Veit, R., Gaber, T., Rota, G., Kuebler, A., et al. (2007). FMRI brain-computer interface: a tool for neuroscientific research and treatment. Comput. Intell. Neurosci. 2007:25487. doi: 10.1155/2007/25487

PubMed Abstract | CrossRef Full Text | Google Scholar

Tangermann, M., Müller, K. R., Aertsen, A., Birbaumer, N., Braun, C., Brunner, C., et al. (2012). Review of the BCI competition IV. Front. Neurosci. 6:55. doi: 10.3389/fnins.2012.00055

PubMed Abstract | CrossRef Full Text | Google Scholar

Wolpaw, J. R., and Winter Wolpaw, E. (2012). “Brain–computer interfaces: something new under the sun,” in Brain–Computer InterfacesPrinciples and Practice, eds J. R. Wolpaw and E. W. Wolpaw (Oxford: Oxford University Press), 3–12. doi: 10.1093/acprof:oso/9780195388855.003.0001

CrossRef Full Text | Google Scholar

Yger, F., Berar, M., and Lotte, F. (2017). Riemannian approaches in brain-computer interfaces: a review. IEEE Trans. Neural Syst. Rehabil. Eng. 25, 1753–1762. doi: 10.1109/TNSRE.2016.2627016

PubMed Abstract | CrossRef Full Text | Google Scholar

Zhang, X., Yao, L., Wang, X., Monaghan, J., Mcalpine, D., and Zhang, Y. (2019). A survey on deep learning based brain computer interface: recent advances and new frontiers. ACM Int. Conf. Proc. Ser. 1, 504–513.

Google Scholar

Zhao, D., Tang, F., Si, B., and Feng, X. (2019). Learning joint space–time–frequency features for EEG decoding on small labeled data. Neural Netw. 114, 67–77. doi: 10.1016/j.neunet.2019.02.009

PubMed Abstract | CrossRef Full Text | Google Scholar

Zhao, H., Yu, S., Prinable, J., McEwan, A., and Karlsson, P. (2020). “A feasible classification algorithm for event-related potential (ERP) based brain-computer-interface (BCI) from IFMBE scientific challenge dataset,” in XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019, eds J. Henriques, N. Neves, and P. de Carvalho (Cham: Springer), 1861–1868. doi: 10.1007/978-3-030-31635-8_226

CrossRef Full Text | Google Scholar

Zou, Y., Zhao, X., Chu, Y., Zhao, Y., Xu, W., and Han, J. (2019). An inter-subject model to reduce the calibration time for motion imagination-based brain-computer interface. Med. Biol. Eng. Comput. 57, 939–952. doi: 10.1007/s11517-018-1917-x

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: P300, EEG, benchmark dataset, brain-computer interface, autism spectrum disorder, multi-session, multi-subject

Citation: Simões M, Borra D, Santamaría-Vázquez E, GBT-UPM, Bittencourt-Villalpando M, Krzemiński D, Miladinović A, Neural_Engineering_Group, Schmid T, Zhao H, Amaral C, Direito B, Henriques J, Carvalho P and Castelo-Branco M (2020) BCIAUT-P300: A Multi-Session and Multi-Subject Benchmark Dataset on Autism for P300-Based Brain-Computer-Interfaces. Front. Neurosci. 14:568104. doi: 10.3389/fnins.2020.568104

Received: 31 May 2020; Accepted: 24 August 2020;
Published: 18 September 2020.

Edited by:

Davide Valeriani, Massachusetts Eye and Ear Infirmary and Harvard Medical School, United States

Reviewed by:

Tomasz Maciej Rutkowski, RIKEN Center for Advanced Intelligence Project (AIP), Japan
Motoaki Kawanabe, Advanced Telecommunications Research Institute International (ATR), Japan

Copyright © 2020 Simões, Borra, Santamaría-Vázquez, GBT-UPM, Bittencourt-Villalpando, Krzemiński, Miladinovic, Neural_Engineering_Group, Schmid, Zhao, Amaral, Direito, Henriques, Carvalho and Castelo-Branco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Marco Simões, msimoes@dei.uc.pt; marcoamsimoes@gmail.com; Davide Borra, davide.borra2@unibo.it; Miguel Castelo-Branco, mcbranco@fmed.uc.pt

These authors have contributed equally to this work and share first authorship