Che Jiang1†
Zhensheng Li2†Chenggang Du3Xiwu Zhang1Zhuang Chen1Gaoquan Luo1Xiaona Wu1Jiajia Wang1Yan Cai1Gang Zhao1*‡
Hongmin Bai1*‡- 1Department of Neurosurgery, General Hospital of Southern Theatre Command, Guangzhou, China
- 2Department of Neurology, General Hospital of Southern Theatre Command, Guangzhou, China
- 3Department of Health Service, General Hospital of Southern Theatre Command, Guangzhou, China
Post-traumatic stress disorder (PTSD) can develop after stroke attacks, and its rate ranges from 4 to 37% in the stroke population. Suffering from PTSD not only decreases stroke patient’s quality of life, but also relates to their non-adherence of treatment. Since strokes often recur and progress, long-term medical management is especially important. However, previous studies generally focused on the epidemiological characteristics of post-stroke PTSD, while there are literally no studies on the psychological intervention. In our study, 170 patients with a first-ever stroke during the acute phase were recruited. They were randomized into Psycho-therapy group 1 and Control group 1, and were administered with preventive intervention for PTSD or routine health education, respectively. At 2-month follow-up, PTSD symptoms were evaluated. Participants who were diagnosed with post-stroke PTSD were further randomized into Psycho-therapy group 2 and Control group 2, and received supportive therapy or routine health counseling, respectively. At 6-month follow-up (1°month after the therapy was completed), PTSD symptoms were re-evaluated. Our results showed that at 2-month, the PTSD incidence in our series was 11.69%, and the severity of stroke was the only risk factor for PTSD development. The preventive intervention was not superior to routine health education for PTSD prevention. At 6-month, results indicated the supportive therapy did have a fine effect in ameliorating symptoms for diagnosed PTSD patients, superior to routine health counseling. Thus, our study was the first to provide evidence that the supportive therapy was effective in treating post-stroke PTSD early after its diagnosis. This clinical trial was preregistered on www.chictr.org.cn (ChiCTR2100048411).
Introduction
Post-traumatic stress disorder (PTSD) is a mental disorder which may develop after individuals exposed to traumatic events. The common events include accidents, combat, physical attack, childhood abuse, robbery, natural disasters, and so on. According to the Statistical Manual of Mental Disorders-version 5 (DSM-5) (American Psychiatric Association [APA], 2013), PTSD is characterized by four clusters of symptoms including persistent intrusive memories, avoidance of reminders, negative alterations in mood and cognition, and hyper-arousal (American Psychiatric Association [APA], 2013). PTSD is also associated with increased risk of drug abuse, suicide, and other mental disorders (Kessler et al., 1995). In the general population, the lifetime incidence of trauma exposure is estimated to be over 50%, and the incidence of PTSD to be 3–7% (McManus et al., 2007; Kessler et al., 2017).
Stroke presents one of the leading causes of death and disability worldwide (Béjot et al., 2016). Secondary psychological symptoms such as depression and anxiety commonly occur (Towfighi et al., 2017). Stroke features sudden onset of neurologic deficits and is potentially life-threatening, thus conforms to the definition of traumatic events in post-traumatic disorder (PTSD). Emerging studies have focused on post-stroke PTSD in the past two decades. The prevalence of PTSD (or PTSD symptom) in stroke population ranged from 4 to 37% (Garton et al., 2017), and even mild stroke (Bruggimann et al., 2006) and transient ischemic stroke (TIA) (Kiphuth et al., 2014) can cause PTSD. Since strokes often recur and progress, long-term medical management is especially important. Suffering from PTSD not only decreases stroke patient’s quality of life (QOL) (Noble et al., 2008), but also relates to their non-adherence of treatment (Kronish et al., 2012; Edmondson et al., 2013a).
Psychotherapies for prevention or treatment of PTSD primarily include exposure therapy, cognitive processing therapy (CPT), and eye movement desensitization and reprocessing (EMDR). After treatment, although most patients can attain clinically meaningful symptom improvement, approximately two-thirds retained PTSD diagnosis (Maria et al., 2015). On the other hand, there are also pharmacotherapeutic ways for the management of PTSD, such as selective serotonin reuptake inhibitors (SSRIs), norepinephrine and dopamine reuptake inhibitors (NDRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), anticonvulsants, antidepressants, and benzodiazepines (Akhtar and Pilkhwal Sah, 2021). Yet, they showed limited efficacy, excessive adverse effects, and lower patient compliance. As for post-stroke PTSD, previous studies generally focused on the rate and risk factors, while there are literally no studies on its prevention or treatment (Garton et al., 2017). Compared with PTSD caused by non-medical factors, post-stroke PTSD has its unique pathophysiological characteristics and may require different psychological therapies.
Within the first 3°months of a traumatic event, the traumatic memory remains fragmented (Van der Kolk, 1994; Foa et al., 2010; Shapiro, 2012). Early psychological intervention conducted during this period may keep these memories from accumulation (McFarlene, 2010), so it is crucial for the prevention and treatment of PTSD. Thus, our study focused on the early psychological intervention for the prevention and treatment of post-stroke PTSD. It is argued that stroke patients’ maladaptive coping strategies and their exaggerated belief of stroke’s harmfulness may be the main cause for PTSD. Therefore, extended health education in the acute stage of the stroke, guiding patients to adopt suitable coping styles, and correctly understand the risk of stroke seems likely to help prevent secondary PTSD (Noble et al., 2008; Kiphuth et al., 2014). As for the treatment of post-stroke PTSD, we hypothesized that supportive therapy with medical counseling implemented early after the PTSD diagnosis may be effective. In our prospective clinical trial, we showed the efficacy of supportive therapy, but not extended health education.
Materials and methods
This was an exploratory pilot randomized controlled trial (ChiCTR2100048411). The study was preregistered1 and the data was shared on the website www.medresman.org.cn. The flow diagram was shown in Figure 1.
Figure 1. Flow diagram of this study.
Patients
Inclusion and exclusion criteria
Participants were enrolled according to the following inclusion and exclusion criteria. Inclusion criteria: patients with a first-ever cerebral hemorrhage, cerebral infarction, TIA, or subarachnoid hemorrhage (SAH) admitted to our hospital from September 2021 to March 2022. Exclusion criteria: time since onset of stroke > 2 weeks; age < 18 years or > 80 years; history of mental illness; severe aphasia or cognitive impairment; refused to participate in this study. Patients with stroke progression, underwent craniotomy during hospitalization, did not cooperate with allocated interventions, or were misdiagnosed were also excluded at discharge.
One hundred and seventy patients were initially included on admission and were randomly assigned to Psycho-therapy group 1 (n = 85) and Control group 1 (n = 85). At discharge, participants were excluded for misdiagnosis (n = 6), receiving craniotomy (n = 1), non-adherence to intervention (n = 3), stroke progression to consciousness disorder (n = 2). At 2-month follow-up, 3 were lost and 1 was excluded for death caused by mitral valve replacement, thus, a total of 154 participants were included for baseline analysis (75 participants in Psycho-therapy group 1 and 79 in Control group 1). Eighteen patients were diagnosed with post-stroke PTSD and were randomly assigned to Psycho-therapy group 2 (n = 9) and Control group 2 (n = 9). They were followed for an additional 4 months. One of them was excluded for non-adherence to the psycho-therapy. Thus, 17 patients (8 participants in psycho-therapy group 2 and 9 in control group 2) were finally involved for the analysis.
Ethical approval to conduct this study was granted by the ethics committee of our hospital (number: GHSTC-2020-055).
Randomization and grouping
The participants on admission were randomly assigned to psycho-therapy group 1 or control group 1 by random number table. At 2-months follow-up, participants from both groups diagnosed with post-stroke PTSD were further randomly divided into psycho-therapy group 2 or control group 2.
Procedures
During hospitalization, participants received treatment for stroke. Routine stroke education and nursing was applied for the Control group 1, while preventive intervention for PTSD was applied for the Psycho-therapy group 1. Baseline characteristics were collected: age, sex, income, employment, education, family status, religion, National Institute of Health stroke scale (NIHSS) score, modified Rankin scale (mRS) score, stroke type, lesion site, size of hematomas, underwent surgery or not, and length of hospital stay.
Follow-ups were conducted through outpatient or smartphones. At 2-month follow-up after the onset of stroke, NIHSS scores, stroke recurrence, diagnosed PTSD, and the Post Traumatic Stress Disorder Checklist for DSM-5 (PCL-5) scores were recorded and compared between Control group 1 and Psycho-therapy group 1. The patients who were diagnosed with PTSD were randomly divided into Psycho-therapy group 2 or Control group 2. Patients in the Psycho-therapy group 2 received supportive psychotherapy (12 sessions in a total of 3 months) thereafter, and patients in control group 2 received routine health education (several minutes) once a month.
At 6-month follow-up, NIHSS scores, stroke recurrence, diagnosed PTSD, and PCL-5 scores were recorded and compared between Control group 2 and Psycho-therapy group 2. The participants were then thanked and reimbursed. Participants who continued to have mental problems were referred to neurology/psychology clinics.
Psycho-therapy for post-traumatic stress disorder
(1) Routine health education for stroke patients during hospitalization included irregular education at convenience (several minutes each time, about 3–5 times each week) and group education for 1 or 2 times (each last for around half an hour).
(2) Preventive intervention for PTSD. Besides routine health education, patients received extended health education (each session contained two sub-sessions lasting half an hour, one session a week), which emphasized on guiding patients to adopt good coping style, correctly understand the risk of stroke, understand that medication and regular follow-ups can reduce the risk of stroke recurrence. In addition, by actively communicating with patients, therapists observed their emotional status, applying psychological debriefing and other means to encourage patients to emotional release.
(3) Routine health counseling during follow up was implemented approximately once a month through face-to-face conversation or video chat. Each session last 10 to 15 min. The content included education of stroke and PTSD, and the way to adopt good coping styles.
(4) Supportive therapy. This therapy was conducted once a week for a total of 12 weeks (each session last around 50 min), through face-to-face conversation or video chat on smartphone or laptop. The detailed goals and contents of each session were listed in Table 1.
Table 1. Protocols of supportive therapy.
Measures
Diagnosis of post-traumatic stress disorder
The PTSD Checklist for DSM-5 (PCL-5) was used to evaluate the severity of PTSD symptoms. For the participants with potential PTSD screened by the checklist, further interviews were conducted to confirm the diagnosis with the Clinician Administered PTSD Scale for DSM-5 (CAPS-5).
PCL-5
This is a self-rated scale, and is used to evaluate PTSD symptom severity. It contains 20 items, each rated from 0 (not at all) to 4 (extremely) on a five-point Likert type scale. The scores are summed to a total score. The Chinese version of PCL-5 has been widely used in traumatized Chinese samples and showed good internal consistencies (α = 0.95) (Wang et al., 2017; Li et al., 2018).
CAPS-5
This scale was used for a structured diagnostic interview to assess PTSD diagnostic status. It conforms to DSM-5 criteria for PTSD, and includes 20 items correspond to criteria B to E. The severity of each item is rated on a 0 (absent) to 4 (extreme) scale. Items rated 2 (Moderate) or greater indicate clinically significant symptoms. A PTSD diagnosis is obtained if clinically significant symptoms present at least one in re-experiencing, one in avoidance, two in negative alterations in cognitions and mood, and two in alterations in arousal and reactivity symptoms. CAPS-5 demonstrated high internal consistency, strong interrater reliability and test-retest reliability (Weathers et al., 2018).
Statistical analysis
Quantitative variables were analyzed using Student’s t test or Mann-Whitney U test, and qualitative variables were analyzed with Pearson’s chi-square test or Fisher’s exact test. The changes of PCL-5 scores from 2-month follow-up to 6-month follow-up were analyzed between Psycho-therapy group 2 and Control group 2 by ANCOVA tests. Logistic regression analyses (enter) were performed to evaluate the association of different variables with diagnosed PTSD at 2-month follow-up. Statistical analysis was performed by Statistical Package for the Social Sciences (version 19.0 for Windows; SPSS, Chicago, IL, USA), and a P value of < 0.05 was considered significant.
Results
Baseline characteristics were listed in Table 2. The average age was 59 years old and male patients constituted the majority of participants. More participants were unemployed, had lower income, and have no religion. Cerebral infarction represented the most common type of stroke and the severity of stroke was generally mild. No significant difference of baseline characteristics between Psycho-therapy group 1 and Control group 1 was found. The overall duration of preventive intervention of PTSD was significantly longer than the normal health education (2.19 ± 0.75 h vs. 0.85 ± 0.39 h, P < 0.001), while it did not increase non-adherence of participants.
Table 2. Baseline characteristics.
At 2-month follow-up, 18 of the 154 participants (11.69%) were diagnosed with PTSD. Patients diagnosed with PTSD showed significantly higher NIHSS scores (more severe neurological deficits) than those without PTSD (6.17 ± 4.42 vs. 1.90 ± 2.36, P < 0.001). No other parameters (age, sex, income, employment status, type of stroke, lesion site, etc.) showed significant difference between PTSD and non-PTSD patients (data not shown). Logistic regression analyses further revealed NIHSS scores as a predictor of PTSD diagnosis (P < 0.001, B = −0.36, OR = 0.70, 95% CI = 0.59–0.82). No significant difference existed in stroke or PTSD status between Psycho-therapy group 1 and Control group 1 (Table 3).
Table 3. Parameters of stroke and post-traumatic stress disorder (PTSD) at 2-month follow-up.
The participants with PTSD diagnosis were then randomly divided into Psycho-therapy group 2 and Control group 2. During the intervention process, one participant in the Psycho-therapy group 2 did not cooperate well with the intervention after the first session and withdrew from the research. The rest eight participants received appropriate number (9∼12) of sessions. One participant underwent a mild recurrence of stroke, but continued the psycho-therapy. All nine participants in the Control group two completed the trial. At 6-month follow-up, ANCOVA tests showed a significantly greater reduction of the PCL-5 scores in the Psycho-therapy group 2 than those in the Control group 2 [F(1, 14) = 10.29, P = 0.01, ηp2 = 0.42]. In the Psycho-therapy group 2, 6 patients in the Psycho-therapy group 2 were relieved from PTSD, while only 1 patient in the Control group 2 got relieved (Table 4).
Table 4. Characteristics of patients with post-stroke post-traumatic stress disorder (PTSD) at 6-month follow-up.
Discussion
As far as we know, this was the first study specifically focused on the psychotherapy on the prevention and treatment of post-stroke PTSD. We proved that the supportive therapy has a fine effect in treating post-stroke PTSD early after its diagnosis and it is well tolerated by patients. We also showed that the strengthened health education during the acute phase of stroke may not have a preventive effect of PTSD compared with normal health education.
Epidemiology and risk factors of post-stroke post-traumatic stress disorder
The diagnosis of PTSD should be obtained with strict clinical interviews, while self-reported scales can only report probable PTSD of PTSD-like symptoms (PTSS). Most previous studies used only self-reported scales but lacked interviews. These studies report conflicting rates, from 4% to as high as 37% (Bruggimann et al., 2006). A meta-analysis in 2013 revealed the estimated rate of PTSD/PTSS following stroke or TIA was 23% within 1 year and 11% after 1 year (Edmondson et al., 2013b). Some more recent studies showed relatively lower rate: 7.5% within the first 5 days after ictus (Edmondson et al., 2013b), 10% (Pedowitz et al., 2021) or 11.0% at one month (Liyanage-Don et al., 2021), 12.9% at 3 months (Rutovic et al., 2021), 6.5% (Garton et al., 2020) or 11% (Assayag et al., 2022) at 12 months, although one reported as high as 32.8% at 3 months to 5 years follow-up (Dollenberg et al., 2021). The discrepancies between various studies may be partially explained by heterogeneity in study methodology (e.g., subtypes of stroke, first-ever or recurrent stroke, investigation time after stroke attack, definition of PTSD by DSM-IV or DSM-V, diagnosed by clinical interview or self-reported scales, and different scales used for the assessment).
In our experience, the degree of cognitive impairment is also presumed to be a key reason. Patients with mild to moderate cognitive impairment usually could not be fully aware of the risk of stroke despite repeated explanations by medical staffs, so they consequently experienced little stress, even less than their family members. It is of note that the proportion of this population is not low (nearly equal to the included population), but was all excluded from our study, which may lead to the overestimation of PTSD incidence. If this population was included, the actual incidence of post-stroke PTSD in our series may very likely to be no more than 6%. In the future, the relationship between cognitive impairment and PTSD development is needed to be revealed and epidemiological studies should clarify patients to what extent of cognitive impairment (e.g., measured by scales like Montreal Cognitive Assessment) are excluded.
Another important methodological factor we propose that potentially influence the PTSD incidence is the way of health education: the more serious the medical staffs informed about strokes, the more distressed felt by patients and their family members. So, it is a test of communication skills to properly inform the risk of strokes to the patients while not to increase their psychologic burden.
It has been consistently shown that higher degree of stroke disability is positively correlated with both acute distress and PTSD symptoms (Garton et al., 2020; Pedowitz et al., 2021; Rutovic et al., 2021; Assayag et al., 2022). Other potential risk factors include lesions localized in the right cerebral hemisphere and brain stem (Rutovic et al., 2021), white matter damage (Assayag et al., 2022), minimally invasive surgery (Jiang, 2020), younger age, female sex, dysfunctional coping strategies, negative cognitive appraisals, lower education and unemployment status, uninsured status, etc. (Garton et al., 2017). However, a definitive consensus has yet been reached. Our present study showed only stroke severity predicted PTSD development, indicating somatic disability to be a strong risk factor.
Preventive intervention for post-stroke post-traumatic stress disorder
There are various therapies developed for the prevention of PTSD in adults. Yet, as reviewed in an article including only randomized controlled trials (RCTs), there lacks evidence for any intervention that can be strongly recommended for PTSD prevention (Bisson et al., 2021). Attention bias modification training, as a way of pre-incident preparedness, showed effects (Wald et al., 2016). After traumatic events happen, interventions like eye movement desensitization and reprocessing (EMDR) (Jarero et al., 2011; Tarquinio et al., 2016), individual/group psychological debriefing, brief individual trauma processing therapies, and trauma-focused cognitive behavioral therapy (CBT) may be helpful (Bisson et al., 2021). A small proportion of these studies focused on acute medical conditions such as premature delivery (Shaw et al., 2013; Borghini et al., 2014), miscarriage (Lee et al., 1996), caesarian section (Horsch et al., 2017), myocardial infarction (von Känel et al., 2018), mechanical ventilation in ICU (Jensen et al., 2016; Cox et al., 2018) or ICU stay (Jones et al., 2010), family members of patients (Kazak et al., 2005; Curtis et al., 2016), and transplant surgery (Irvine et al., 2011). However, no effective therapy was found in these studies, except for one favored brief individual trauma processing therapy on traumatic childbirth (Gamble et al., 2005). Another review showed evidence that midwifery or clinician led early psychological interventions (including CBT counseling, debriefing, EMDR, visual spatial tasks, etc.) administered within 72 h after childbirth to be more effective than usual care (Miller et al., 2021).
Besides behavior ways, various pharmacological agents like hydrocortisone (Bisson et al., 2021), SSRIs and anticonvulsants (Akhtar and Pilkhwal Sah, 2021) may be helpful in the management PTSD symptoms. However, due to the limited evidence and their adverse effects, they cannot be recommended for routine use of PTSD prevention (Astill Wright et al., 2019).
Our preventive therapy is the combination of health education and debriefing counseling. The treatment strength was comparable to previous therapies on patients with traumatic childbirth which is commonly 1 or 2 sessions (40 to 60 min for each session). We did not find a superiority of our preventive therapy over routine health education. Combined with previous studies, it may indicate that the prevention of PTSD is relatively difficult, or, preventive interventions would be better to be selectively delivered to individuals who have developed symptoms, since they are likely to benefit more from the interventions (Bisson et al., 2021). Considering stroke patient’s tolerance, the duration of our preventive intervention is long enough, and it is not likely to improve the therapeutic efficacy by simply increasing time length. Future studies may be better focused on therapies based on other mechanisms. As stated above, the actual incidence of post-stroke PTSD in our hospital is relatively low. Thus, another possibility which we believed more is that the routine health education administered in the control group also exerted preventive effects. Besides explaining the state of stroke illness to patients and their caretakers by doctors and nurses irregularly, we offered a group education once a week, which contains lectures given by doctors and interactions between doctors and patients. So, a clear knowledge of the stroke disease can be achieved by this kind to health education. During the coronavirus disease 2019 (COVID-19) pandemic, our department generally required every patient to be accompanied by one family member during hospitalization (Simnani et al., 2022). The caring of family members can offer great comfort to the patients. With this kind of health education and family caring, patients are probably more resistant to mental disorders.
Psychotherapy for the treatment of post-stroke post-traumatic stress disorder
Traditional behavioral therapies for PTSD include exposure therapy, CBT, EMDR, cognitive processing therapy (CPT), etc. Although these therapies can reduce PTSD symptoms, there are still 1/3 (Kessler et al., 1995) to 2/3 (Steenkamp et al., 2015) patients left with PTSD diagnosis after treatment.
Post-traumatic stress disorder (PTSD) after stroke and PTSD caused by non-medical factors have different pathophysiological characteristics. The former is affected by brain lesions, while the latter lacks a clear physiological precipitant (Garton et al., 2017). The traumatic focal points of stroke are often the uncertainty about future health, fear of recurrent attacks, disability, and changes of social status (McCurley et al., 2019). Stroke patients are commonly middle and old aged, and often have various comorbidities like hypertension and diabetes. Additionally, patients generally need to take medications for a long period of time, which serve as a traumatic reminder (Liyanage-Don et al., 2021). Exposure therapy is considered as the first-line treatment for PTSD caused by various types of traumas (Rauch et al., 2012); however, it may not be adequate for post-stroke PTSD. Because exposure therapy takes effect through repeated confrontations of trauma-related stimuli but without the occurrence of feared consequences, by which the patient is habituated to emotional responses and regains self-competence. In contrast, different from other types of traumas, stroke does have the potential to recur and worsen, threatening individual’s life. So, a treatment aiming at help post-stroke PTSD patients establish a correct understanding of disease, adapt to new environment, and offers comfort may be a better choice.
It seems that the features mentioned above of post-stroke PTSD make patients persistently reminded of the traumatic events and affected by unfavorable outcomes of stroke. These may be adverse factors for treatment efficacy. However, our study showed that the 12-session supportive therapy had a fine effect, with 75% of post-stroke PTSD patients being ameliorated at 1°month after therapy completion. In some cases, even nine sessions of intervention showed favorable therapeutic effects. The favorable outcome may be partly due to the relatively old age of stroke patients. Older age is a protective factor for developing PTSD, as found by some previous studies (Garton et al., 2017). Likewise, older patients with PTSD may be more prone to accept unfavorable situations after psychological therapy. Another reason lies in the way our supportive therapy administered to patients. The majority of treatment sessions were delivered through video chat on smartphones or laptops. Multiple studies reported non-inferiority of online-based psychotherapy, which is far more convenient and cost-effective than in vivo methods (Spence et al., 2014; Littleton et al., 2016; Nieminen et al., 2016; Lewis et al., 2017; Olden et al., 2017). We believe that the online interaction is good for establishing trust and intimacy between patients and therapists, since the patients can readily get answers to the problems relating to their illnesses through communicating with therapists.
There are some limitations of our study. Firstly, it should be noted that we only followed for 1°month after the treatment for PTSD, so the long-term effect is unknown and requires further study. Secondly, since the brain lesions varied in our stroke patient sample, which may potentially affect the PTSD pathophysiology, it is more desirable to include stroke patients with lesions in similar brain regions. Thirdly, as the development of PTSD is influenced by social and cultural background, it should be cautious when translating our results to populations of different countries. Finally, whether shorter treatment sessions can also achieve desirable effects remains to be revealed.
Data availability statement
The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found below: http://www.medresman.org.cn/uc/patient/patientlist.aspx?proj=8135m (user name: pna; password: 222222).
Ethics statement
The studies involving human participants were reviewed and approved by the Ethics Committee of the PLA General Hospital of Southern Theatre Command. The patients/participants provided their written informed consent to participate in this study.
Author contributions
HB and CJ designed the research. CJ and ZL analyzed the data and wrote the manuscript. ZL, CD, ZC, GL, XW, JW, and YC collected the data. GZ and XZ critically reviewed the manuscript. HB approved the final manuscript. All authors contributed to the article.
Funding
This work was supported by the Science and Technology Planning Project of Guangzhou (grant number: 202102021268).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Footnotes
References
Akhtar, A., and Pilkhwal Sah, S. (2021). Advances in the pharmacotherapeutic management of post-traumatic stress disorder. Expert Opin. Pharmacother. 22, 1919–1930.
American Psychiatric Association [APA] (2013). Diagnostic and statistical manual of mental disorders, 5th Edn. Arlington, VA: American Psychiatric Publishing.
Assayag, E. B., Tene, O., Korczyn, A. D., Solomon, Z., Bornstein, N. M., Shenhar-Tsarfaty, S., et al. (2022). Posttraumatic stress symptoms after stroke: The effects of anatomy and coping style. Stroke 53, 1924–1933. doi: 10.1161/STROKEAHA.121.036635
Astill Wright, L., Sijbrandij, M., Sinnerton, R., Lewis, C., Roberts, N. P., and Bisson, J. I. (2019). Pharmacological prevention and early treatment of post-traumatic stress disorder and acute stress disorder: A systematic review and meta-analysis. Transl. Psychiatry 9:334.
Béjot, Y., Daubail, B., and Giroud, M. (2016). Epidemiology of stroke and transient ischemic attacks: Current knowledge and perspectives. Rev. Neurol. 172, 59–68. doi: 10.1016/j.neurol.2015.07.013
Bisson, J. I., Wright, L. A., Jones, K. A., Lewis, C., Phelps, A. J., Sijbrandij, M., et al. (2021). Preventing the onset of post traumatic stress disorder. Clin. Psychol. Rev. 86:102004. doi: 10.1016/j.cpr.2021.102004
Borghini, A., Habersaat, S., Forcada-Guex, M., Nessi, J., Pierrehumbert, B., Ansermet, F., et al. (2014). Effects of an early intervention on maternal post-traumatic stress symptoms and the quality of mother-infant interaction: The case of preterm birth. Infant Behav. Dev. 37, 624–631. doi: 10.1016/j.infbeh.2014.08.003
Bruggimann, L., Annoni, J. M., Staub, F., von Steinbüchel, N., Van der Linden, M., and Bogousslavsky, J. (2006). Chronic posttraumatic stress symptoms after nonsevere stroke. Neurology 66, 513–516. doi: 10.1212/01.wnl.0000194210.98757.49
Cox, C. E., Hough, C. L., Carson, S. S., White, D. B., Kahn, J. M., Olsen, M. K., et al. (2018). Effects of a telephone- and web-based coping skills training program compared with an education program for survivors of critical illness and their family members a randomized clinical trial. Am. J. Respir. Crit. Care Med. 197, 66–78. doi: 10.1164/rccm.201704-0720OC
Curtis, J. R., Treece, P. D., Nielsen, E. L., Gold, J., Ciechanowski, P. S., Shannon, S. E., et al. (2016). Randomized trial of communication facilitators to reduce family distress and intensity of end-of-life care. Am. J. Respir. Crit. Med. 193, 154–162.
Dollenberg, A., Moeller, S., Lücke, C., Wang, R., Lam, A. P., Philipsen, A., et al. (2021). Prevalence and influencing factors of chronic post-traumatic stress disorder in patients with myocardial infarction, transient ischemic attack (TIA) and stroke - an exploratory, descriptive study. BMC Psychiatry 21:295. doi: 10.1186/s12888-021-03303-1
Edmondson, D., Horowitz, C. R., Goldfinger, J. Z., Fei, K., and Kronish, I. M. (2013a). Concerns about medications mediate the association of posttraumatic stress disorder with adherence to medication in stroke survivors. Br. J. Health Psychol. 18, 799–813. doi: 10.1111/bjhp.12022
Edmondson, D., Richardson, S., Fausett, J. K., Falzon, L., Howard, V. J., and Kronish, I. M. (2013b). Prevalence of PTSD in survivors of stroke and transient ischemic attack: A meta-analytic review. PLoS One 8:e66435. doi: 10.1371/journal.pone.0066435
Foa, E. B., Keane, T. M., Friedman, M. J., and Cohen, J. A. (eds). (2010). Effective treatments for PTSD: Practice guidelines from the international society for traumatic stress studies. New York, NY: Guilford Press.
Gamble, J., Creedy, D., Moyle, W., Webster, J., McAllister, M., and Dickson, P. (2005). Effectiveness of a counseling intervention after a traumatic childbirth: A randomized controlled trial. Birth 32, 11–19.
Garton, A. L. A., Gupta, V. P., Pucci, J. U., Couch, C. K., and Connolly, E. S. (2020). Incidence and predictors of post-traumatic stress symptoms in a cohort of patients with intracerebral hemorrhage. Clin. Neurol. Neurosurg. 190:105657. doi: 10.1016/j.clineuro.2019.105657
Garton, A. L. A., Sisti, J. A., Gupta, V. P., Christophe, B. R., and Connolly, E. S. Jr. (2017). Post-stroke posttraumatic stress disorder: A review. Stroke 48, 507–512.
Horsch, A., Vial, Y., Favrod, C., Morisod Harari, M., Blackwell, S. E., Watson, S., et al. (2017). Reducing intrusive traumatic memories after emergency caesarean section: A proof-of-principle randomized controlled study. Behav. Res. Ther. 94, 36–47. doi: 10.1016/j.brat.2017.03.018
Irvine, J., Firestone, J., Ong, L., Cribbie, R., Dorian, P., Harris, L., et al. (2011). A randomized controlled trial of cognitive behavior therapy tailored to psychological adaptation to an implantable cardioverter defibrillator. Psychosom. Med. 73, 226–233. doi: 10.1097/PSY.0b013e31820afc63
Jarero, I., Artegas, L., and Luber, M. (2011). The EMDR protocol for recent critical incidents: Application in a disaster mental health continuum of care context. J. EMDR Pract. Res. 5, 82–94.
Jensen, J. F., Egerod, I., Bestle, M. H., Christensen, D. F., Elklit, A., Hansen, R. L., et al. (2016). A recovery program to improve quality of life, sense of coherence and psychological health in ICU survivors: A multicenter randomized controlled trial, the RAPIT study. Intensive Care Med. 42, 1733–1743. doi: 10.1007/s00134-016-4522-1
Jiang, C. (2020). Posttraumatic stress disorder after a first-ever intracerebral hemorrhage in the Chinese population: A pilot study. Appl. Neuropsychol. Adult 27, 1–8. doi: 10.1080/23279095.2018.1451334
Jones, C., Bäckman, C., Capuzzo, M., Egerod, I., Flaatten, H., Granja, C., et al. (2010). Intensive care diaries reduce new onset post traumatic stress disorder following critical illness: A randomised, controlled trial. Crit. Care 14:R168.
Kazak, A. E., Simms, S., Alderfer, M. A., Rourke, M. T., Crump, T., McClure, K., et al. (2005). Feasibility and preliminary outcomes from a pilot study of a brief psychological intervention for families of children newly diagnosed with cancer. J. Pediatr. Psychol. 30, 644–655. doi: 10.1093/jpepsy/jsi051
Kessler, R. C., Aguilar-Gaxiola, S., Alonso, J., Benjet, C., Bromet, E. J., Cardoso, G., et al. (2017). Trauma and PTSD in the WHO world mental health surveys. Eur. J. Psychotraumatol. 8(Suppl. 5):1353383.
Kessler, R. C., Sonnega, A., Bromet, E., Hughes, M., and Nelson, C. B. (1995). Posttraumatic stress disorder in the National comorbidity survey. Arch. Gen. Psychiatry 52, 1048–1060.
Kiphuth, I. C., Utz, K. S., Noble, A. J., Köhrmann, M., and Schenk, T. (2014). Increased prevalence of posttraumatic stress disorder in patients after transient ischemic attack. Stroke 45, 3360–3366.
Kronish, I. M., Edmondson, D., Goldfinger, J. Z., Fei, K., and Horowitz, C. R. (2012). Posttraumatic stress disorder and adherence to medications in survivors of strokes and transient ischemic attacks. Stroke 43, 2192–2197.
Lee, C., Slade, P., and Lygo, V. (1996). The influence of psychological debriefing on emotional adaptation in women following early miscarriage: A preliminary study. Br. J. Med. Psychol. 69(Pt 1), 47–58. doi: 10.1111/j.2044-8341.1996.tb01849.x
Lewis, C. E., Farewell, D., Groves, V., Kitchiner, N. J., Roberts, N. P., Vick, T., et al. (2017). Internet-based guided self-help for posttraumatic stress disorder (PTSD): Randomized controlled trial. Depress. Anxiety 34, 555–565.
Li, G., Wang, L., Cao, C., Fang, R., Liu, P., Luo, S., et al. (2018). DSM-5 posttraumatic stress symptom dimensions and health-related quality of life among Chinese earthquake survivors. Eur. J. Psychotraumatol. 9:1468710. doi: 10.1080/20008198.2018.1468710
Littleton, H., Grills, A. E., Kline, K. D., Schoemann, A. M., and Dodd, J. C. (2016). The from survivor to thriver program: RCT of an online therapist-facilitated program for rape-related PTSD. J. Anxiety Disord. 43, 41–51. doi: 10.1016/j.janxdis.2016.07.010
Liyanage-Don, N., Birk, J., Cornelius, T., Sanchez, G., Moise, N., Edmondson, D., et al. (2021). Medications as traumatic reminders in patients with stroke/transient ischemic attack-induced posttraumatic stress disorder. Stroke 52, 321–324. doi: 10.1161/STROKEAHA.120.031109
Maria, M. S., Brett, T. L., Charles, W. H., and Charles, R. M. (2015). Psychotherapy for military-related PTSD: A review of randomized clinical trials. JAMA 314, 489–500.
McCurley, J. L., Funes, C. J., Zale, E. L., Lin, A., Jacobo, M., Jacobs, J. M., et al. (2019). Preventing chronic emotional distress in stroke survivors and their informal caregivers. Neurocrit. Care 30, 581–589.
McFarlene, A. C. (2010). The long-term costs of traumatic stress: Intertwined physical and psychological consequences. World Psychiatry 9:3. doi: 10.1002/j.2051-5545.2010.tb00254.x
McManus, S., Meltzer, H., Brugha, T., Bebbington, P., and Jenkins, R. (eds). (2007). Adult psychiatric morbidity in England, 2007: Results of a household survey. London: NHS Information Centre for Health and Social Care.
Miller, P. G. T., Sinclair, M., Gillen, P., McCullough, J. E. M., Miller, P. W., Farrell, D. P., et al. (2021). Early psychological interventions for prevention and treatment of post-traumatic stress disorder (PTSD) and post-traumatic stress symptoms in post-partum women: A systematic review and meta-analysis. PLoS One 16:e0258170. doi: 10.1371/journal.pone.0258170
Nieminen, K., Berg, I., Frankenstein, K., Viita, L., Larsson, K., Persson, U., et al. (2016). Internet-provided cognitive behaviour therapy of posttraumatic stress symptoms following childbirth-a randomized controlled trial. Cogn. Behav. Ther. 45, 287–306. doi: 10.1080/16506073.2016.1169626
Noble, A. J., Baisch, S., Mendelow, A. D., Allen, L., Kane, P., and Schenk, T. (2008). Posttraumatic stress disorder explains reduced quality of life in subarachnoid hemorrhage patients in both the short and long term. Neurosurgery 63, 1095–1104. doi: 10.1227/01.NEU.0000327580.91345.78
Olden, M., Wyka, K., Cukor, J., Peskin, M., Altemus, M., Lee, F. S., et al. (2017). Pilot study of a telehealth-delivered medication-augmented exposure therapy protocol for PTSD. J. Nerv. Ment. Dis. 205, 154–160. doi: 10.1097/NMD.0000000000000563
Pedowitz, E., Derby, L., Cruz, G. J., Trainor, A., Edmondson, D., and Cornelius, T. (2021). Relationship between NIH stroke symptoms and post-traumatic stress disorder in patients evaluated for transient ischemic attack/stroke. Gen. Hosp. Psychiatry 70, 98–102. doi: 10.1016/j.genhosppsych.2021.03.004
Rauch, S. A., Eftekhari, A., and Ruzek, J. I. (2012). Review of exposure therapy: A gold standard for PTSD treatment. J. Rehabil. Res. Dev. 49, 679–687. doi: 10.1682/jrrd.2011.08.0152
Rutovic, S., Kadojic, D., Dikanovic, M., Solic, K., and Malojcic, B. (2021). Prevalence and correlates of post-traumatic stress disorder after ischaemic stroke. Acta Neurol. Belg. 121, 437–442.
Shapiro, E. (2012). EMDR and early psychological intervention following trauma. Eur. Rev. Appl. Psychol. 62, 241–251.
Shaw, R. J., St John, N., Lilo, E. A., Jo, B., Benitz, W., Stevenson, D. K., et al. (2013). Prevention of traumatic stress in mothers with preterm infants: A randomized controlled trial. Paediatrics 132, e886–e894.
Simnani, F. Z., Singh, D., Choudhury, A., and Akhtar, A. (2022). Impact of COVID-19 on brain and psychological health, its possible mechanisms, and coping strategies. Recent Pat. Biotechnol. Epub ahead of print. doi: 10.2174/1872208316666220617110402
Spence, J., Titov, N., Johnston, L., Jones, M. P., Dear, B. F., and Solley, K. (2014). Internet-based trauma-focused cognitive behavioural therapy for PTSD with and without exposure components: A randomised controlled trial. J. Affect. Disord. 162, 73–80. doi: 10.1016/j.jad.2014.03.009
Steenkamp, M. M., Litz, B. T., Hoge, C. W., and Marmar, C. R. (2015). Psychotherapy for military-related PTSD: A review of randomized clinical trials. JAMA 314, 489–500.
Tarquinio, C., Rotonda, C., Houll’e, W. A., Montel, S., Rydberg, J. A., Minary, L., et al. (2016). Early psychological preventive intervention for workplace violence: A randomized controlled explorative and comparative study between EMDR-recent event and critical incident stress debriefing. Issues Ment. Health Nurs. 37, 787–799. doi: 10.1080/01612840.2016.1224282
Towfighi, A., Ovbiagele, B., El Husseini, N., Hackett, M. L., Jorge, R. E., Kissela, B. M., et al. (2017). Poststroke depression: A scientific statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 48, e30–e43. doi: 10.1161/STR.0000000000000113
Van der Kolk, B. A. (1994). The body keeps the score: Memory and the evolving psychobiology of posttraumatic stress. Harv. Rev. Psychiatry 1, 253–265. doi: 10.3109/10673229409017088
von Känel, R., Barth, J., Princip, M., Meister-Langraf, R. E., Schmid, J. P., Znoj, H., et al. (2018). Early psychological counseling for the prevention of posttraumatic stress induced by acute coronary syndrome: The MI-SPRINT randomized controlled trial. Psychother. Psychosom. 87, 75–84.
Wald, I., Fruchter, E., Ginat, K., Stolin, E., Dagan, D., Bliese, P., et al. (2016). Selective prevention of combat-related post-traumatic stress disorder using attention bias modification training: A randomized controlled trial. Psychol. Med. 46, 2627–2636. doi: 10.1017/S0033291716000945
Wang, L., Cao, X., Cao, C., Fang, R., Yang, H., and Elhai, J. D. (2017). Factor structure of DSM-5 PTSD symptoms in trauma-exposed adolescents: Examining stability across time. J. Anxiety Disord. 52, 88–94. doi: 10.1016/j.janxdis.2017.07.001
Keywords: stroke, post-traumatic stress-disorder, psychological intervention, supportive therapy, early stage
Citation: Jiang C, Li Z, Du C, Zhang X, Chen Z, Luo G, Wu X, Wang J, Cai Y, Zhao G and Bai H (2022) Supportive psychological therapy can effectively treat post-stroke post-traumatic stress disorder at the early stage. Front. Neurosci. 16:1007571. doi: 10.3389/fnins.2022.1007571
Received: 30 July 2022; Accepted: 26 September 2022;
Published: 06 October 2022.
Edited by:
Hu Zhao, Sun Yat-sen University, ChinaReviewed by:
Ansab Akhtar, University of Petroleum and Energy Studies, IndiaRobert Perna, University of Michigan Medical Center, United States
Copyright © 2022 Jiang, Li, Du, Zhang, Chen, Luo, Wu, Wang, Cai, Zhao and Bai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Hongmin Bai, baihmfmmu@vip.163.com; Gang Zhao, 1443364859@qq.com
†These authors have contributed equally to this work and share first authorship
‡These authors have contributed equally to this work and share last authorship