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Front. Pediatr. | doi: 10.3389/fped.2019.00419

Recurrent pericarditis in children and adolescents

 Enrico Tombetti1*,  TERESA GIANI2, 3, Antonio L. Brucato1 and Rolando Cimaz2, 4
  • 1Department of Biomedical Sciences and Clinics Luigi Sacco, Faculty of Medicine and Surgery, University of Milan, Italy
  • 2Rheumatology Unit, Meyer University Hospital, University of Florence, Italy
  • 3Department of Medical Biotechnology, University of Siena, Italy
  • 4Department of Clinical and Community Sciences, Faculty of Medicine and Surgery, University of Milan, Italy

Recurrent pericarditis (RP) is a clinical syndrome characterized by recurrent attacks of acute pericardial inflammation. Prognosis quoad vitam is good, although morbidity might be significant, especially in children and adolescents. Multiple potential etiologies result in RP, in the vast majority of cases through autoimmune or autoinflammatory mechanisms. Idiopathic RP is one of the most frequent diagnoses, that requires the exclusion of all known etiologies. Therapeutic advances in the last decade have been significant with the recognition of the effectiveness of anti IL1 therapy, but a correct diagnostic and therapeutic algorithm is of key importance. Unfortunately, most of evidence comes from studies in adult patients. Here we review the etiopathogenesis, diagnosis and management of RP in pediatric patients.

Keywords: Pericarditis, myopericarditis, Children, adolescents, pediatric, Autoinflammatory diseases

Received: 29 Jul 2019; Accepted: 02 Oct 2019.

Copyright: © 2019 Tombetti, GIANI, Brucato and Cimaz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Enrico Tombetti, Department of Biomedical Sciences and Clinics Luigi Sacco, Faculty of Medicine and Surgery, University of Milan, Milan, Italy, enricotombetti@gmail.com