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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pediatr. | doi: 10.3389/fped.2019.00488

Health-Related Physical Fitness and Quality of Life in Children and Adolescents with Isolated Left-to-Right Shunt

Angeles Fuertes Moure1,  Michael Meyer2, 3, Anna-Luisa Häcker2, 3,  Barbara Reiner2, Leon Brudy3,  Renate M. Oberhoffer2, 3, Peter Ewert3 and  Jan Müller2*
  • 1Independent researcher, Spain
  • 2Department of Preventive Pediatrics, Technical University of Munich, Germany
  • 3Department of Paediatric Cardiology and Congenital Heart Defects, German Heart Centre, Germany

Objective: Atrial (ASD) and ventricular septal defects (VSD) represent the most common congenital heart defects (CHD) and are considered simple and curable. This study investigates long-term functional outcomes in children with such defects.
Patients and Methods: We examined 147 patients (74 girls, 12.1 ± 3.5 years) with isolated shunts (ASD: 54%, VSD: 46%) for their Health-Related Physical Fitness (HRPF) and Health-Related Quality of Life (HRQoL). Native condition was present in 58 patients, interventional closure of the defect was performed in 42 and surgical closure in 47. For comparison, a healthy control group (CG) of 1724 children (48.9% girls, 12.8 ± 2.8 years) was recruited within two recent school projects.
Results: After adjustment for age and sex, children with ASD and VSD presented lower HRPF (z-score healthy peers: 0.02 ± 0.73, ASD: -0.41 ± 0.73, p<.001; VSD: -0.61 ± 0.73, p<.001) then healthy peers. Transferred into percentiles, VSD were on the 26th and ASD on the 34th percentile of the healthy peers. HRQoL did not differ between peers and CHD with isolated shunts (healthy peers: 76.1 ± 9.7, ASD: 76.2 ± 9.9, p=.999; VSD: 78.7 ± 9.7, p=.316). Regarding the surgical history of the shunts (native, percutaneously treated, surgically treated), there were also no difference in-between these three states, nor differed HRPF and HRQoL in-between gender.
Conclusions: Children with ASD or VSD have impaired HRPF but normal HRQoL. Early childhood sports promotion could be a good measure to counteract these restrictions in HRPF at an early stage.

Keywords: simple severity, functional outcome, Congenital Hear Defects, Arterial stiffnes, Intima media thickness, Health related qualitiy of life

Received: 25 Apr 2019; Accepted: 06 Nov 2019.

Copyright: © 2019 Fuertes Moure, Meyer, Häcker, Reiner, Brudy, Oberhoffer, Ewert and Müller. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: PhD. Jan Müller, Department of Preventive Pediatrics, Technical University of Munich, München, Germany,