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Front. Vet. Sci. | doi: 10.3389/fvets.2019.00052

Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance from 2008 to 2017

 Eric S. Ontiveros1,  Samantha Fousse1,  Amanda Crofton1, Timothy E. Hodge2, Catherine T. Gunther-Harrington1,  Lance C. Visser1 and  Joshua A. Stern1*
  • 1University of California, Davis, United States
  • 2University of California Veterinary Medical Center, United States

Subvalvular aortic stenosis (SAS) and valvular pulmonic stenosis (PS) are two of the most common congenital heart diseases of dogs. The aim of this study was to determine the prevalence and mode of inheritance of these congenital heart diseases in a large veterinary teaching hospital population. Case records of dogs presented to the University of California Davis, Veterinary Medical Teaching Hospital (UCD VMTH) between January 2008 to December 2017 were reviewed retrospectively and pedigree information was obtained when available. There were 259 unique SAS and 336 unique PS cases diagnosed during the study period. The prevalence of SAS was 0.3% of overall hospital admissions and 4.7% for all dogs seen by the cardiology service. The prevalence for PS was 0.41% of overall hospital admissions and 6.1% of dogs seen by the cardiology service. Bullmastiffs and Newfoundlands had the greatest prevalence (6.59% and 4.46% respectively) and odds ratio (52.43 and 34.73 respectively) for SAS. Bulldogs and French Bulldogs had the greatest prevalence (4.8% and 2.7% respectively) and odds ratio (13.32 and 7.52 respectively) for PS. The identified prevalence of SAS and PS is higher than previously reported. Pedigree analysis in SAS affected Bullmastiffs, Golden Retrievers, and Rottweilers suggested an autosomal recessive pattern of inheritance. The mode of inheritance for PS in Bulldogs, also appears to be autosomal recessive. The results of this study can be used to inform future selection of breeding pairs and genetic studies aimed at reducing the prevalence of these common congenital heart diseases.

Keywords: Genetics, Subvalvular aortic stenosis, Pulmonic stenosis, congenital heart disease, Prevalence, inheritance, Veterinary

Received: 10 Nov 2018; Accepted: 07 Feb 2019.

Edited by:

David Bruyette, Anivive Lifesciences, United States

Reviewed by:

Eva Sierra, Universidad de Las Palmas de Gran Canaria, Spain
Dilip K. Garikipati, Cleveland Clinic, United States
Kirstie Barrett, VCA Inc., United States  

Copyright: © 2019 Ontiveros, Fousse, Crofton, Hodge, Gunther-Harrington, Visser and Stern. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Joshua A. Stern, University of California, Davis, Davis, United States,