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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Vet. Sci. | doi: 10.3389/fvets.2019.00355

Pharmacokinetics of tylvalosin in broiler turkeys (Meleagris gallopavo) after single intravenous and oral administration

 Mohamed Elbadawy1*,  Mohamed Aboubakr1 and Amira Abugomaa2
  • 1Faculty of Veterinary Medicine. Benha University, Egypt
  • 2Faculty of Veterinary Medicine, Mansoura University, Egypt

Pharmacokinetics of tylvalosin (TVN) were determined in eight broiler turkeys following a single intravenous (IV) and peroral (PO) administration of 25 mg/kg b.w using crossover design with a 3 weeks washout period. Blood samples were taken between 0.083 and 24 h following TVN administration, plasma was separated and assayed for TVN concentrations by HPLC. The non-compartmental analysis was used to analyze plasma concentration-time curves. After IV administration, the pharmacokinetic profile was best described by a two-compartment model. The mean distribution and elimination half-lives were 0.382 and 5.71 h, respectively. The distribution volume at steady state, total body clearance and mean residence time were 8.30 L/kg, 1.17 L/h and 7.16 h, respectively. After administering orally, the mean absorption half-life and absorption time of TVN was 0.955 and 2.31 h, respectively. The peak plasma concentration was 1.08 μg/mL and achieved at 2.0 h post-administration and the bioavailability was 53.3%. The plasma protein binding percent was 13%. For a successful clinical efficacy of TVN in broiler turkeys, a dosage regimen of 25 mg/kg b.w, given orally each day is recommended to keep efficient plasma levels above the MIC for most susceptible microorganisms.

Keywords: bioavailability, Macrolides, pharmacokinetics, Tylvalosin, broilers, Turkeys 3

Received: 17 Aug 2019; Accepted: 27 Sep 2019.

Copyright: © 2019 Elbadawy, Aboubakr and Abugomaa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Mohamed Elbadawy, Faculty of Veterinary Medicine. Benha University, Benha, Egypt, mohamed.elbadawy@fvtm.bu.edu.eg