Frontiers in Aging Neuroscience | Alzheimer's Disease and Related Dementias

Original Research

Accepted on 29 Apr 2025

Identification and validation of pyroptosis-related genes in Alzheimer's disease based on multi-transcriptome and machine learning

in Alzheimer's Disease and Related Dementias

Zhuoze Wu
Yuntai Wang
Yilin Li
Lu Zhou
Yihuan Yuan
Chuanfei Liu
Zimeng Zeng
Yuanqi Chen
Qi He

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1568337

Review

Accepted on 28 Apr 2025

Review of FUNDC1-mediated mitochondrial autophagy in Alzheimer's disease

in Alzheimer's Disease and Related Dementias

Dandan Shi
Xiaochen Guo
Ziqi Ning
Yaoyao Zhang
Fang Liu
Meixia Liu
Yun Wei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1544241

Original Research

Accepted on 28 Apr 2025

Plasma neurofilament light chain mediates the effect of subsyndromal symptomatic depression on cognitive decline in older adults

in Alzheimer's Disease and Related Dementias

Chunhua Zhang
Bingyu Li
Kok Pin Ng
Guojuan Huang
Xijin Wang
Min Kong
Maowen Ba

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547394

Correction

Accepted on 28 Apr 2025

Corrigendum: Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer's Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis

in Alzheimer's Disease and Related Dementias

Diling Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1593725

Original Research

Published on 28 Apr 2025

Early emergence of motivational and hedonic feeding deficits in the TgF344-AD rat model of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Sean B. Ostlund
Grace Chen
Alisa Kosheleff
Lindsay M Lueptow
Irina Zhuravka
Sally A. Frautschy
Hoa A. Lam
Nigel T. Maidment

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1572956

247 views

Mini Review

Published on 25 Apr 2025

The potential and challenges of TREM2-targeted therapy in Alzheimer’s disease: insights from the INVOKE-2 study

in Alzheimer's Disease and Related Dementias

Ya-nan Ma
Xiqi Hu
Kenji Karako
Peipei Song
Wei Tang
Ying Xia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576020

871 views

Original Research

Accepted on 24 Apr 2025

Mirodenafil Improves Cognitive Function by Reducing Microglial Activation and Blood-Brain Barrier Permeability in ApoE4 KI Mice

in Alzheimer's Disease and Related Dementias

Yejin Park
Subin Moon
Harry Jung
Songyi Park
Ju Won Kim
Dan-Gyeong Song
Yong-Ho In
Sang Won Han
Jong-Hee Sohn
Chan Hee Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579411

Review

Accepted on 23 Apr 2025

Iron Responsive Elements (IREs)-mRNA Regulate Alzheimer's Amyloid Precursor Protein (APP) Translation through Iron Sensing

in Alzheimer's Disease and Related Dementias

Mateen A. Khan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1483913

100 views

Original Research

Accepted on 23 Apr 2025

Blood biomarker as surrogate endpoint in Alzheimer's disease research

in Alzheimer's Disease and Related Dementias

Guogen Shan
Hui Li
Yahui Zhang
Guoqiao Wang
Charles Bernick

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576373

142 views

Systematic Review

Published on 23 Apr 2025

Neural correlates of subjective cognitive decline in Alzheimer’s disease: a systematic review of structural and functional brain changes for early diagnosis and intervention

in Alzheimer's Disease and Related Dementias

Giulia Marafioti
Laura Culicetto
Desirèe Latella
Angela Marra
Angelo Quartarone
Viviana Lo Buono

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549134

908 views

Review

Published on 23 Apr 2025

The role of quantitative EEG biomarkers in Alzheimer’s disease and mild cognitive impairment: applications and insights

in Alzheimer's Disease and Related Dementias

Yue Yuan
Yang Zhao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1522552

966 views

Original Research

Published on 22 Apr 2025

Early identification of mild cognitive impairment: an innovative model using ocular biomarkers

in Alzheimer's Disease and Related Dementias

Lingjing Zhang
Yanwei Wang
Yuming Liu
Zi Ye
Zhaohui Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1492804

953 views

Original Research

Published on 22 Apr 2025

Relationship between cerebrospinal fluid circulation markers, brain degeneration, and cognitive impairment in cerebral amyloid angiopathy

in Alzheimer's Disease and Related Dementias

Li Zhao
Lingyun Liu
Miao Lin
Linyun Xie
Hui Hong
Qingze Zeng
Shuyue Wang
Ruiting Zhang
Zhenhua Zhao
Peiyu Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549072

883 views

Original Research

Accepted on 21 Apr 2025

Association of low-density lipoprotein/high-density lipoprotein ratio with cognition, Alzheimer's disease biomarkers and brain structure

in Alzheimer's Disease and Related Dementias

Zihao Zhang
Lingzhi Ma
Liangyu Huang
Yangke Zhu
Haihua Guo
Lanyang Wang
Wei Zhang
Lan Tan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1457160

Study Protocol

Accepted on 18 Apr 2025

Multi-pathway blood biomarkers to target and monitor multidimensional prevention of cognitive and functional decline (nested in the IN-TeMPO study framed within the World-Wide FINGERS network)

in Alzheimer's Disease and Related Dementias

Gessica Sala
Luca Cuffaro
Federico Emanuele Pozzi
Simona Andreoni
Chiara Bazzini
Elisa Conti
Chiara Paola Zoia
Simone Beretta
Lucio Tremolizzo
Giuseppe Bellelli

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1581892

118 views

Review

Accepted on 17 Apr 2025

Polyphenols and miRNA interplay: A novel approach to combat apoptosis and inflammation in Alzheimer's disease

in Alzheimer's Disease and Related Dementias

Minji zhou
Xiue Pang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571563

166 views