Frontiers in Aging Neuroscience

Original Research

Published on 11 Nov 2025

Interpretable machine learning for cognitive impairment prediction in Parkinson’s disease: a multicenter validation study with SHAP analysis

Ziyuan Wang
Junqiang Yan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688653

1,864 views

Original Research

Published on 10 Nov 2025

Brain activity during cognitive-motor tasks in older adults with cognitive frailty: a fNIRS study

Yin-Hsiang Wang
Yea-Ru Yang
Nai-Chen Yeh
Pei-Yun Li
Ray-Yau Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1682050

1,511 views

Original Research

Published on 07 Nov 2025

Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease

Faruk Hossen
Javier Hung
Hamza Odeh
Grace Y. Sun
James C. Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1671986

2,400 views

Review

Published on 07 Nov 2025

Exercise modulation of gut microbiota in Alzheimer’s disease: pathophysiological mechanisms and therapeutic perspectives

Si-yi Leng
Qi-hang Yang
Yang Yuan
Bingao Chen
Hongbao Chen
Weikang Ban
Jiahao Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1677896

2,271 views
1 citation

Original Research

Published on 07 Nov 2025

Astrocytic Ror2-induced imbalance in brain and gut homeostasis contributes to chronic post-thoracotomy pain

Chaoqun Liu
Le Shen
Li Xu
Afang Zhu
Yuguang Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1675725

1,609 views

Review

Published on 06 Nov 2025

Biological determinants of blood-based biomarker levels in Alzheimer’s disease: role of nutrition, inflammation, and metabolic factors

Aparna Inamdar
Parashuram Bugadannavar
Mahesh Palled
Savita Umarani
Preeti Salve
Bannimath Gurupadayya
Priyanka Patil
Himanshu Sharma

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1614962

3,576 views
2 citations

Original Research

Published on 06 Nov 2025

Dynamic decline in estimated glomerular filtration rate associated with in-hospital mortality risk in acute ischemic stroke patients after endovascular therapy: evidence from a Chinese stroke center

Yanping Lin
Jingjing She
Lijuan Cai
Lingfeng Yu
Shouyue Jin
Xingyu Chen
Weiwei Gao
Renjing Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1598371

1,230 views

Original Research

Published on 05 Nov 2025

Variations in body condition score, inflammatory and metabolic biomarkers predict cognitive changes in clinically healthy senior cats

Holly Memoli
Mariangela Albertini
Irit Grader
Lena Provoost
Joel Filipe
Patrizia Piotti
Paola Scarpa
Darko Stefanovski
Federica Pirrone
Carlo Siracusa

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1703764

2,962 views

Original Research

Published on 05 Nov 2025

A trajectory study of postoperative frailty and cognitive function in elderly spinal surgery patients: a cohort study in China

Rui Li
Qian Deng
Cheng Peng
Hong Song
Xiaotian Shan
Yao Wang
Chunyan Jin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1554901

1,211 views
1 citation

Review

Published on 05 Nov 2025

Brain microenvironment orchestrates highly aggressive tumor variants: current trends and therapeutic approaches

Juhi Mishra
John D. Dickinson
Shailendra Kumar Maurya

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1666837

1,805 views

Review

Published on 05 Nov 2025

Cross-generational mechanisms of maternal gut microbiota in modulating offspring autism spectrum disorder risk: from the gut-brain axis to translational challenges in precision interventions

Dashuang Zhang
Min Zhou
Yudan Qiu
Hong Xu
Hanmin Liu
Yang Liu
Liang Xie

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1642240

3,379 views

Original Research

Published on 05 Nov 2025

Influence of diabetes on the efficacy of DL-3-n-butylphthalide in post-stroke cognitive impairment: a 12-month prospective cohort study

Yuting Lu
Lifeng Wang
Juan Hao
Jingjing Song
Chenxi Fan
Xianjia Ning
Jinghua Wang
Yan Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1649248

1,637 views

Original Research

Published on 03 Nov 2025

From genomic discovery to application in age-related hearing loss: a global bibliometric and cross-ethnic analysis

Yang Lu
Jiawei Shen
Ka Ho Kairos Sou
Hsi Lu
Shuoyuan Huang
Kai Uus

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1678115

2,601 views

Original Research

Published on 31 Oct 2025

Brain connectivity moderated the effects of cognitive intraindividual variability on mobility in cognitively frail older adults

Jingyi Wu
Jinyu Chen
Juncen Wu
Wayne Lap Sun Chan
Yijian Yang
Chun Liang Hsu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1682996

1,631 views

Original Research

Published on 31 Oct 2025

Spatial transcriptomics reveals an unexpected impact of tau and tau pathology on the expression of transthyretin

Deborah L. Croteau
Jose Fernandez Navarro
Thomas Comptdaer
Zaneta Andrusivova
Aleksandra Jurek
Eliette Bonnefoy
Luc Buée
Vilhelm A. Bohr
Joakim Lundeberg
Marie-Christine Galas

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1656850

1,915 views

Original Research

Published on 31 Oct 2025

Prevalence, associated factors and impact of mild cognitive impairment in hospitalized older adults with Parkinson’s disease: a cross-sectional study

Siyuan Gong
Tianqi Wang
Rongzhu Tang
Wangjuan Hu
Wenjing Wang
Jia Li
Jihong Liu
Chunlian Liao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1693417

1,510 views

Mini Review

Published on 29 Oct 2025

Improving recognition and management of inpatient delirium in Parkinson’s disease: evidence review and implications for clinical care

Colin Coleman
Adrianne Smiley
Sheera Rosenfeld
Anne Brooks

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1693827

1,925 views

Original Research

Published on 29 Oct 2025

An intricate relationship: stress markers and associative memory in a laboratory experiment in older adults

Luisa Knopf
Gregor Domes
Siri-Maria Kamp

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1666566

1,201 views

Review

Published on 28 Oct 2025

Drug discovery and development for Parkinson’s disease: are preclinical models good enough?

Alejandro Reinares-Sebastián
Noelia Esteban-García
Masahiko Takada
Inés Trigo-Damas

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692592

2,872 views

Original Research

Published on 28 Oct 2025

Directed brain connectivity biomarkers of healthy aging and Parkinson’s disease staging

Tauqeer Anjum
Ali Seyfizadeh
Hao Ding
Tahir Mahmood
Rüdiger Pryss
Jens Volkmann
Dumitru Ciolac
Muthuraman Muthuraman

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1698600

1,702 views

Original Research

Published on 27 Oct 2025

Multimodal radiomics of cerebellar subregions for machine learning-driven Alzheimer’s disease diagnosis

Xinqing Hao
Ying Li
Xiulin Wang
Changjun Ma
Ruichen Liu
Yang Jiao
Chunbo Dong
Jing Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679788

1,576 views

Original Research

Published on 27 Oct 2025

Chronic kidney disease, proteinuria, and mortality risk in patients with Parkinson’s disease: a 12-year longitudinal study

Kyoungwon Baik
Minwoong Kang
Yu Jeong Park
Su Jin Chung
Kyungmi Oh
Sung Hoon Kang
Seong-Beom Koh

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1631079

1,346 views

Editorial

Published on 27 Oct 2025

Editorial: Neuroinflammation and distribution of proinflammatory markers in the brain

Huazheng Liang
Yong Hao
Yong Bi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1723530

1,347 views

Original Research

Published on 23 Oct 2025

Peak alpha frequency as an objective biomarker for cognitive assessment in post-stroke cognitive impairment

Yuqing Zhao
Haoran Shi
Weicheng Kong
Xinyang Wang
Wei Wei
Zengtu Zhan
Xiehua Xue

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1639970

2,059 views

7,810 Publications

volumes

Volume 17 - 2025

Interpretable machine learning for cognitive impairment prediction in Parkinson’s disease: a multicenter validation study with SHAP analysis

Brain activity during cognitive-motor tasks in older adults with cognitive frailty: a fNIRS study

Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease

Exercise modulation of gut microbiota in Alzheimer’s disease: pathophysiological mechanisms and therapeutic perspectives

Astrocytic Ror2-induced imbalance in brain and gut homeostasis contributes to chronic post-thoracotomy pain

Biological determinants of blood-based biomarker levels in Alzheimer’s disease: role of nutrition, inflammation, and metabolic factors

Dynamic decline in estimated glomerular filtration rate associated with in-hospital mortality risk in acute ischemic stroke patients after endovascular therapy: evidence from a Chinese stroke center

Variations in body condition score, inflammatory and metabolic biomarkers predict cognitive changes in clinically healthy senior cats

A trajectory study of postoperative frailty and cognitive function in elderly spinal surgery patients: a cohort study in China

Brain microenvironment orchestrates highly aggressive tumor variants: current trends and therapeutic approaches

Cross-generational mechanisms of maternal gut microbiota in modulating offspring autism spectrum disorder risk: from the gut-brain axis to translational challenges in precision interventions

Influence of diabetes on the efficacy of DL-3-n-butylphthalide in post-stroke cognitive impairment: a 12-month prospective cohort study

From genomic discovery to application in age-related hearing loss: a global bibliometric and cross-ethnic analysis

Brain connectivity moderated the effects of cognitive intraindividual variability on mobility in cognitively frail older adults

Spatial transcriptomics reveals an unexpected impact of tau and tau pathology on the expression of transthyretin

Prevalence, associated factors and impact of mild cognitive impairment in hospitalized older adults with Parkinson’s disease: a cross-sectional study

Improving recognition and management of inpatient delirium in Parkinson’s disease: evidence review and implications for clinical care

An intricate relationship: stress markers and associative memory in a laboratory experiment in older adults

Drug discovery and development for Parkinson’s disease: are preclinical models good enough?

Directed brain connectivity biomarkers of healthy aging and Parkinson’s disease staging

Multimodal radiomics of cerebellar subregions for machine learning-driven Alzheimer’s disease diagnosis

Chronic kidney disease, proteinuria, and mortality risk in patients with Parkinson’s disease: a 12-year longitudinal study

Editorial: Neuroinflammation and distribution of proinflammatory markers in the brain

Peak alpha frequency as an objective biomarker for cognitive assessment in post-stroke cognitive impairment