Frontiers in Aging Neuroscience

Original Research

Published on 10 Oct 2025

Deciphering Alzheimer’s disease transcriptomics: exploration and validation of core genes in tau and Aβ pathological models toward novel therapeutic targets

Hui E. Zhang
Meng Li Xiao
Jin Jin Ji
Yu Rong Cheng
Fang Lu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1621153

2,713 views

Original Research

Published on 10 Oct 2025

Clinical validation of a plasma-based antibody-free LC–MS method for identifying CSF amyloid positivity in mild cognitive impairment

José Antonio Allué
Leticia Sarasa
Noelia Fandos
Ricardo Gonzalo
Rubén Sabido-Vera
Jorge Loscos
Judith Romero
Adrián Sánchez
Jose Terencio
Jordi A. Matias-Guiu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1681516

2,202 views
1 citation

Original Research

Published on 10 Oct 2025

Asrij/OCIAD1 contributes to age-associated microglial activation and neuroinflammation in mice

Prathamesh Dongre
Madhu Ramesh
Thimmaiah Govindaraju
Maneesha S. Inamdar

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1674136

2,397 views

Original Research

Published on 10 Oct 2025

Attention-based Transformer-LSTM architecture for early diagnosis and staging of early-stage Parkinson’s disease using fNIRS data

Huan Wang
Hujun Wang
Shuyan Qie
Congxiao Wang
Nan Li
Hanming Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1677722

2,326 views
1 citation

Review

Published on 09 Oct 2025

Parkinson’s disease beyond the brain: implications for treatments

Setareh Malekian Naeini
Marc Danzell Lopez
Paul E. Fraser
Anurag Tandon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1600782

2,400 views
1 citation

Original Research

Published on 09 Oct 2025

Impairment of human spatial orientation in the horizontal, but not the vertical plane, due to aging, cognitive decline, or chronic peripheral vestibular loss

Johannes Gerb
Vivien Oertle
Burak Onmus
Marianne Dieterich
Thomas Brandt

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1671562

1,978 views
1 citation

Original Research

Published on 09 Oct 2025

Tortuous extracranial arteries contribute to white Matter hyperintensities in aging brains

Zhe Sun
Chenyang Li
Arjun V. Masurkar
Marco Muccio
Thomas Wisniewski
Yulin Ge

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1641214

1,643 views
1 citation

Systematic Review

Published on 09 Oct 2025

Dysregulation of melatonin rhythm in Parkinson’s and Huntington’s disease: a systematic review and meta-analysis

Reema Priyanka Suram
Rida Fatima
Rajesh Madhuvilakku
Jin Ho Jung
Sang Jin Kim
Yonggeun Hong

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637881

2,107 views

Original Research

Published on 08 Oct 2025

In vivo quantification of superficial cortical veins on susceptibility-weighted imaging with artificial intelligence image segmentation and the potential mechanism of human cognitive decline

Qi Xie
Hai-Xia Xu
Ya-Jie Wang
Hui-Xian Chen
Xiao-Fang Tu
Peng-Peng Han
Jun Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1557397

1,853 views

Systematic Review

Published on 07 Oct 2025

Cognitive changes preceding Parkinson's disease: a systematic review and meta-analysis of prospective population-based studies

Noelia Peña Arauzo
Christoph Theyer
Florian Krismer
Atbin Djamshidian
Werner Poewe
Corinne Horlings
Beatrice Heim
Laura Zamarian
Philipp Mahlknecht

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1627221

2,484 views

Review

Published on 07 Oct 2025

Kynurenine pathway: a possible new mechanism for exercise in the prevention and treatment of Alzheimer's disease

Gangqiang Li
Shuang Li
Wenhui Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617690

2,585 views

Mini Review

Published on 06 Oct 2025

Biomarkers of balance and gait deficits in FMR1 premutation carriers: a mini-review

Leila C. Moore
Nell Maltman
Jonathan S. Lee-Confer
Megan J. Kobel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637819

1,672 views

Original Research

Published on 06 Oct 2025

The association between chronic rhinosinusitis and the risk of dementia: a longitudinal study

Xinyu Zhang
Zhongmin Yin
Jia Luo
Runsheng Yang
Weijing Wang
Dongfeng Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1609790

3,222 views

Original Research

Published on 02 Oct 2025

Predictive gene expression signatures for Alzheimer’s disease using post-mortem brain tissue

Ashley H. Duche
Oliver Tan
Andrius Baskys
Rachita K. Sumbria
Moom R. Roosan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1591946

3,244 views
1 citation

Review

Published on 02 Oct 2025

Role of lipocalin-2 in amyotrophic lateral sclerosis

Zhuoya Wang
Wen Cao
Dongsheng Fan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1672903

3,224 views

Review

Published on 01 Oct 2025

The microbiota–gut–brain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention

Lidya K. Yassin
Jurga Skrabulyte-Barbulescu
Shamsa H. Alshamsi
Sara Saeed
Shamma H. Alkuwaiti
Saif Almazrouei
Abeer Alnuaimi
Shamsa BaniYas
Dana Aldhaheri
Mahra Alderei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1667448

14,613 views
3 citations

Original Research

Published on 01 Oct 2025

Western diet-induced visceral adipose tissue inflammation promotes Alzheimer’s disease pathology via microglial activation in a mouse model

Ji Sun Lim
Soyoung Kwak
Mi-Hee Yu
Mee-Na Park
Hye Suk Baek
Junho Kang
Jeong-Ho Hong
Jin Kyung Kim
Hye Won Lee
Sang-Woo Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1644988

2,893 views

Original Research

Published on 30 Sep 2025

Five-year dementia prediction and decision support system based on real-world data

Themis P. Exarchos
George A. Dimakopoulos
Konstantinos Lazaros
Marios Krokidis
Aristidis Vrahatis
Gerasimos Grammenos
Antigoni Avramouli
Konstantina Skolariki
Roy Adams
Vasiliki Mahairaki

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670609

3,332 views
2 citations

Original Research

Published on 26 Sep 2025

A 15-year bibliometric analysis of body mass index moderation in the management of Parkinson’s disease

Qiying Liu
Ying Chen
Shuyi Chen
Tao Qiu
Ziyi Guo
Yuqiang Lu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1614719

2,101 views

Original Research

Published on 26 Sep 2025

EEG-based minimum spanning tree analysis reveals network disruptions in Alzheimer’s disease spectrum: an observational study

Xing Ye
Yixin Yan
Yingying Wang
Jingping Shi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1604345

2,329 views

Mini Review

Published on 25 Sep 2025

Role of store-operated Ca2+ entry and STIM2 in retinal neurodegeneration during glaucoma

Sofiia Baranykova

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1657590

2,688 views

Systematic Review

Published on 25 Sep 2025

Effects of three aerobic exercise modalities (walking, running, and cycling) on circulating brain-derived neurotrophic factor in older adults: a systematic review and meta-analysis

Yang Cheng
Yuxiang Liu
Jing Ma
Zhen Li
Enli Han
Shumin Bo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1673786

4,573 views

Original Research

Published on 25 Sep 2025

Early-life hearing loss induces persistent cognitive deficits: evidence from human data and a mouse model with environmental intervention

Xuehua Zhou
Huiqian Yu
Yiru Wang
Kaizheng Chen
Xia Shen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1662732

2,047 views

Review

Published on 25 Sep 2025

Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases

Ravindran Jaganathan
Ashok Iyaswamy
Senthilkumar Krishnamoorthi
Abhimanyu Thakur
Siva Sundara Kumar Durairajan
Chuanbin Yang
Dapkupar Wankhar

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1627921

4,704 views
3 citations

7,810 Publications

volumes

Volume 17 - 2025

Deciphering Alzheimer’s disease transcriptomics: exploration and validation of core genes in tau and Aβ pathological models toward novel therapeutic targets

Clinical validation of a plasma-based antibody-free LC–MS method for identifying CSF amyloid positivity in mild cognitive impairment

Asrij/OCIAD1 contributes to age-associated microglial activation and neuroinflammation in mice

Attention-based Transformer-LSTM architecture for early diagnosis and staging of early-stage Parkinson’s disease using fNIRS data

Parkinson’s disease beyond the brain: implications for treatments

Impairment of human spatial orientation in the horizontal, but not the vertical plane, due to aging, cognitive decline, or chronic peripheral vestibular loss

Tortuous extracranial arteries contribute to white Matter hyperintensities in aging brains

Dysregulation of melatonin rhythm in Parkinson’s and Huntington’s disease: a systematic review and meta-analysis

In vivo quantification of superficial cortical veins on susceptibility-weighted imaging with artificial intelligence image segmentation and the potential mechanism of human cognitive decline

Cognitive changes preceding Parkinson's disease: a systematic review and meta-analysis of prospective population-based studies

Kynurenine pathway: a possible new mechanism for exercise in the prevention and treatment of Alzheimer's disease

Biomarkers of balance and gait deficits in FMR1 premutation carriers: a mini-review

The association between chronic rhinosinusitis and the risk of dementia: a longitudinal study

Predictive gene expression signatures for Alzheimer’s disease using post-mortem brain tissue

Role of lipocalin-2 in amyotrophic lateral sclerosis

The microbiota–gut–brain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention

Western diet-induced visceral adipose tissue inflammation promotes Alzheimer’s disease pathology via microglial activation in a mouse model

Five-year dementia prediction and decision support system based on real-world data

A 15-year bibliometric analysis of body mass index moderation in the management of Parkinson’s disease

EEG-based minimum spanning tree analysis reveals network disruptions in Alzheimer’s disease spectrum: an observational study

Role of store-operated Ca2+ entry and STIM2 in retinal neurodegeneration during glaucoma

Effects of three aerobic exercise modalities (walking, running, and cycling) on circulating brain-derived neurotrophic factor in older adults: a systematic review and meta-analysis

Early-life hearing loss induces persistent cognitive deficits: evidence from human data and a mouse model with environmental intervention

Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases