Frontiers in Aging | Aging and the Immune System

Original Research

Accepted on 26 Jun 2025

Beta-Hydroxybutyrate (BHB) Elicits Concentration-Dependent Anti-Inflammatory Effects on Microglial Cells which are Reversible by Blocking its Monocarboxylate (MCT) Importer

in Aging and the Immune System

Chase Garcia
Ariana Banerjee
Claire Montgomery
Lauren Adcock
Izumi Maezawa
Jon Ramsey
Ana Cristina Grodzki
Kyoungmi Kim
Gino Cortopassi

Frontiers in Aging

doi 10.3389/fragi.2025.1628835

Brief Research Report

Published on 20 May 2025

Hematopoietic stem cell size heterogeneity is not linked to changes in stem cell potential of aged HSCs

in Aging and the Immune System

Mehmet Saçma
Ali Hageb
Alex Zadro
Tanja Schuster
Mona Vogel
Karina Eiwen
Vadim Sakk
Hartmut Geiger

Frontiers in Aging

doi 10.3389/fragi.2025.1596565

1,417 views

Systematic Review

Published on 10 Apr 2025

Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis

in Aging and the Immune System

Beier Jiang
Yi-ni Dong
Yu Xiong
Chun-xia Jiang
Jun Ping
Qi Wu
Liu-jun Xu
Run-zhe Shu
Dan-dan Gao
Sheng-mei Zhu

Frontiers in Aging

doi 10.3389/fragi.2025.1554186

2,694 views

Review

Published on 31 Mar 2025

Premature aging and metabolic diseases: the impact of telomere attrition

in Aging and the Immune System

Sandhya Jinesh
Burçin Özüpek
Prerana Aditi

Frontiers in Aging

doi 10.3389/fragi.2025.1541127

2,517 views
1 citation

Original Research

Published on 10 Mar 2025

Association of systemic immune-inflammatory index with all-cause and cancer mortality in Americans aged 60 years and older

in Aging and the Immune System

Wangfeng Lu
Yuliang Gong
Lei Liu
Yonghong Zhang
Xiaojian Tian
Huanxian Liu

Frontiers in Aging

doi 10.3389/fragi.2025.1502746

1,606 views
1 citation

Editorial

Published on 06 Feb 2025

Editorial: Pathogen-induced immunosenescence: where do vaccines stand?

in Aging and the Immune System

Mehrnoosh Doroudchi
Hamed Fouladseresht

Frontiers in Aging

doi 10.3389/fragi.2025.1560009

666 views

Original Research

Published on 05 Feb 2025

Investigating shared risk variants and genetic etiology between Alzheimer’s disease and three stress-related psychiatric disorders: a large-scale genome-wide cross-trait analysis

in Aging and the Immune System

Weijia Dang
Tianqi Hao
Ning Li
Hualin Zhang
Ziqi Li
Hongmei Yu
Yalu Wen
Deqiang Zheng
Long Liu

Frontiers in Aging

doi 10.3389/fragi.2025.1488528

1,793 views

Original Research

Published on 04 Feb 2025

Immunogenetics of longevity and its association with human endogenous retrovirus K

in Aging and the Immune System

Lisa M. James
Apostolos P. Georgopoulos

Frontiers in Aging

doi 10.3389/fragi.2025.1471202

1,445 views

Brief Research Report

Published on 23 Jan 2025

Markers of immunosenescence in CMV seropositive healthy elderly adults

in Aging and the Immune System

Ivón Johanna Rodríguez
Carlos Alberto Parra-López

Frontiers in Aging

doi 10.3389/fragi.2024.1436346

1,296 views

Mini Review

Published on 23 Jan 2025

The research progress of biologics in elderly-onset rheumatoid arthritis (EORA)

in Aging and the Immune System

Yujie Li
Yifan Liu
Yanhui Tian
Huimin Gu
Qingliang Meng
Jiakang Cui
Junfu Ma

Frontiers in Aging

doi 10.3389/fragi.2024.1511812

2,156 views

Original Research

Published on 06 Jan 2025

Age-associated alterations in immune and inflammatory responses in captive olive baboons (Papio anubis)

in Aging and the Immune System

Michele M. Mulholland
Bharti P. Nehete
Ashley DeLise
Angela M. Achorn
Lisa M. Pytka
Pramod N. Nehete

Frontiers in Aging

doi 10.3389/fragi.2024.1511370

1,558 views

Original Research

Published on 24 Oct 2024

Global burden of inflammatory bowel disease in the elderly: trends from 1990 to 2021 and projections to 2051

in Aging and the Immune System

Ying Liu
Ju Li
Guangxia Yang
Deqian Meng
Xianming Long
Kai Wang

Frontiers in Aging

doi 10.3389/fragi.2024.1479928

2,996 views
4 citations

Original Research

Published on 17 Oct 2024

Prediction of COVID-19 in-hospital mortality in older patients using artificial intelligence: a multicenter study

in Aging and the Immune System

Massimiliano Fedecostante
Jacopo Sabbatinelli
Giuseppina Dell’Aquila
Fabio Salvi
Anna Rita Bonfigli
Stefano Volpato
Caterina Trevisan
Stefano Fumagalli
Fabio Monzani
Raffaele Antonelli Incalzi

Frontiers in Aging

doi 10.3389/fragi.2024.1473632

2,111 views
4 citations

Review

Published on 16 Oct 2024

The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience

in Aging and the Immune System

Marianna V. Wrona
Rituparna Ghosh
Kaitlyn Coll
Connor Chun
Matthew J. Yousefzadeh

Frontiers in Aging

doi 10.3389/fragi.2024.1490302

8,397 views
13 citations

Review

Published on 24 Sep 2024

Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications

in Aging and the Immune System

M. Victoria Delpino
Jorge Quarleri

Frontiers in Aging

doi 10.3389/fragi.2024.1442323

2,760 views
1 citation

Original Research

Published on 23 Aug 2024

Enhanced mitochondrial function in B cells from elderly type-2 diabetes mellitus patients supports intrinsic inflammation

in Aging and the Immune System

Daniela Frasca
Valquiria Bueno

Frontiers in Aging

doi 10.3389/fragi.2024.1444527

1,614 views