ORIGINAL RESEARCH article
Front. Anesthesiol.
Sec. Perioperative Medicine
Volume 4 - 2025 | doi: 10.3389/fanes.2025.1572804
This article is part of the Research TopicInnovative Approaches in Pediatric Surgical Oncology Volume IIView all 9 articles
Multidisciplinary perioperative management of pediatric pheochromocytoma/paraganglioma: a retrospective cohort study with longterm outcomes
Provisionally accepted
- 1Department of Anesthesiology, Shanghai Children's Hospital, Shanghai, Shanghai Municipality, China
- 2Department of SICU, Shanghai Children's Hospital, Shanghai, China
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Background: Pheochromocytoma and paraganglioma (PPGL) pose significant perioperative challenges in pediatric populations due to catecholamine-driven hemodynamic instability. This study systematically evaluates perioperative management strategies-including preoperative optimization, intraoperative protocols, and postoperative monitoring-to establish evidence-based guidance for improving outcomes in pediatric PPGL surgery.Methods: A single-center retrospective cohort study was conducted at a tertiary specialty hospital from January 2014 to October 2023. Clinical data from eight pediatric PPGL patients undergoing surgical resection were analyzed alongside a synthesis of contemporary literature and consensus guidelines.Results: All eight patients received multimodal antihypertensive therapy (phenoxybenzamine, propranolol, and/or calcium channel blockers) for preoperative blood pressure control, achieving normotensive thresholds (<130/80 mmHg). Intraoperative hemodynamic stability was maintained through invasive arterial monitoring and targeted fluid resuscitation, with no hypertensive crises or arrhythmias reported. Postoperatively, normalized urinary vanillylmandelic acid (VMA) levels and blood pressure confirmed biochemical remission. During a median follow-up of 4.5 years (range 7 months-7 years), no instances of tumor recurrence or metastasis were identified.Conclusions: Protocolized perioperative care incorporating α-adrenergic blockade, real-time hemodynamic monitoring, and comprehensive biochemical surveillance ensures safe tumor resection and mitigates surgical risks in pediatric PPGL. These findings underscore the importance of multidisciplinary coordination and long-term follow-up to optimize outcomes in this rare pediatric cohort.
Keywords: Pheochromocytoma 1, paraganglioma 2, pediatric endocrinology 3, perioperative management 4, hypertension 5 Pheochromocytoma, Paraganglioma, Pediatric Endocrinology, Perioperative management
Received: 07 Feb 2025; Accepted: 27 Jun 2025.
Copyright: © 2025 Yu, Ren, Wei, Wang, Ding, Yu, Wei and Zou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tianxiao Zou, Department of Anesthesiology, Shanghai Children's Hospital, Shanghai, 200062, Shanghai Municipality, China
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