REVIEW article
Front. Anesthesiol.
Sec. General Pharmacology and Pharmacokinetics
Volume 4 - 2025 | doi: 10.3389/fanes.2025.1600654
Clinical Applications and Research Progress of Remifentanil
Provisionally accepted
- 1Huzhou Central Hospital affiliated to Huzhou University, Zhejiang Huzhou, China
- 2Huzhou Central Hospital, Huzhou, China
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Remifentanil, an ultra-short-acting μ-opioid receptor agonist, is widely utilized in perioperative and critical care settings due to its rapid metabolism, predictable Pharmacokinetics, and organ-independent clearance. This review synthesizes current evidence on its clinical applications, pharmacological advantages, and emerging challenges, including Opioid-Induced Hyperalgesia (OIH) and labor analgesia. While preclinical studies highlight molecular mechanisms of OIH involving microglial pathways, clinical evidence underscores Remifentanil's efficacy in Hemodynamic Stability, cough suppression, and accelerated recovery. However, translational gaps persist in precision medicine strategies and long-term safety. Future research should prioritize multicenter trials to validate dosing protocols and biomarker-driven approaches.
Keywords: remifentanil, opioid-induced hyperalgesia, Perioperative analgesia, pharmacokinetics, Hemodynamic stability
Received: 28 Mar 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Liu, Meng and Tong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xu Liu, Huzhou Central Hospital affiliated to Huzhou University, Zhejiang Huzhou, China
Zhipeng Meng, Huzhou Central Hospital, Huzhou, 313003, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.