BRIEF RESEARCH REPORT article
Front. Bacteriol.
Sec. Antibiotic Resistance
Volume 4 - 2025 | doi: 10.3389/fbrio.2025.1641773
This article is part of the Research TopicMechanisms and Strategies to Overcome Antibiotic Resistance in Gastrointestinal PathogensView all 5 articles
Current Status of Helicobacter pylori Infection and Prevalence of Resistance-Associated Gene Mutations in Bortala Mongolian Autonomous Prefecture, Xinjiang: A Single-Center Study
Provisionally accepted
- 1Xinjiang Production and Construction Corps, Urumqi, China
- 2Guangdong Provincial People's Hospital, Guangzhou, China
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Background: Helicobacter pylori (H. pylori ), a globally prevalent infectious pathogen, has been epidemiologically associated with dyspepsia, peptic ulcer disease, and gastric carcinogenesis.However, comprehensive regional epidemiological data regarding infection prevalence, antimicrobial resistance patterns, and associated risk factors remain insufficient in the Bortala MongolianAutonomous Prefecture of Xinjiang, China. Methods: A cross-sectional study was conducted from June 4 to June 9, 2023, enrolling 341 participants through systematic sampling in Bortala Prefecture. Diagnostic procedures combined non-invasive urea capsule sampling with genotypic detection techniques for simultaneous H. pylori identification and antimicrobial resistance profiling. Multivariate logistic regression analysis was performed on demographic and behavioral variables obtained through standardized questionnaires. Results: The study revealed an H. pylori infection prevalence of 29.03% (99/341; 95% CI: 24.13–34.34%). Genotypic resistance analysis demonstrated resistance rates of 51.52% (51/99; 95% CI: 41.72–61.32%) for clarithromycin and 46.46% (46/99; 95% CI: 36.66–56.26%) for levofloxacin. Female participants showed a marginally elevated infection risk (OR = 1.27, P = 0.35), while communal cup-sharing behavior demonstrated borderline significance as a risk factor (OR = 1.95, P = 0.09). No statistically significant independent risk factors were identified in the multivariate analysis. Conclusions: The Bortala Prefecture exhibits alarming genotypic resistance patterns to first-line antibiotics, despite a moderate H. pylori infection prevalence. These findings underscore the critical need for region-specific antimicrobial stewardship and evidence-based treatment protocols guided by local resistance profiles. Future research should prioritize stratified sampling methodologies to delineate ethnicity-specific risk profiles and validate potential risk factors in larger cohorts.
Keywords: Helicobacter pylori, Resistance genes, Capsule sampling, Bortala Mongolian Autonomous, antimicrobial resistance patterns
Received: 05 Jun 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 Yuan, Peng, Yang, Lai and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Gai-ling Yuan, Xinjiang Production and Construction Corps, Urumqi, China
Zheng-Kang Li, Guangdong Provincial People's Hospital, Guangzhou, China
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