ORIGINAL RESEARCH article

Front. Behav. Neurosci.

Sec. Individual and Social Behaviors

Volume 19 - 2025 | doi: 10.3389/fnbeh.2025.1564694

Vitamin A Attenuates PFOS-Induced Neurotoxicity and Alters Early Proximity Patterns to Conspecifics in Zebrafish Larvae

Provisionally accepted
Peiyun JiangPeiyun Jiang1Jingyu WangJingyu Wang1Xiaoying WangXiaoying Wang1Li ZouLi Zou1,2Di WuDi Wu1,3Qu XuQu Xu1Yue JiangYue Jiang1Mengmeng YaoMengmeng Yao1,4Qin HongQin Hong1,4*Xia ChiXia Chi1,4*
  • 1Women’s Hospital of Nanjing Medical University (Nanjing Women and Children’s Healthcare Hospital), Nanjing, China
  • 2Department of Pediatrics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
  • 3The Fourth Affliated Hospital of Nanjing Medical University, Nanjing, China
  • 4Nanjing Medical Key Laboratory of Developmental Behavioral Pediatrics, Nanjing, China

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Perfluorooctane sulfonic acid (PFOS) is a stable perfluoroalkyl substance that is widely present in the environment and highly resistant to degradation. Concerns about their possible health effects have been raised in recent years due to their environmental emissions and tendency to bioaccumulate. In this study, we investigate the potential protective effects of Vitamin A against PFOS-induced neurotoxicity, with a particular focus on social behavior deficits, which are key features of autism specturm disorder. Toxic exposure was induced by administering 1 μM and 5 μM of PFOS solution scientific foundation for comprehending the neurotoxicity of PFOS and developing effective intervention measures.

Keywords: PFOs, Social deficit, neurodevelopment, Vitamin A, developmental behavior

Received: 27 Feb 2025; Accepted: 16 May 2025.

Copyright: © 2025 Jiang, Wang, Wang, Zou, Wu, Xu, Jiang, Yao, Hong and Chi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Qin Hong, Women’s Hospital of Nanjing Medical University (Nanjing Women and Children’s Healthcare Hospital), Nanjing, China
Xia Chi, Women’s Hospital of Nanjing Medical University (Nanjing Women and Children’s Healthcare Hospital), Nanjing, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material