REVIEW article
Front. Bioeng. Biotechnol.
Sec. Bioprocess Engineering
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1585736
This article is part of the Research TopicSynthetic Biology Approaches for Biocatalytic Production of Value-Added ChemicalsView all 3 articles
Enzymatic Approaches to Nicotinic Acid Synthesis: Recent Advances and Future Prospects
Provisionally accepted
- Department of Chemical Engineering, Konkuk University, Seoul, Seoul, Republic of Korea
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Biocatalyst-mediated reactions have led to revolutionary transformations in the organic synthesis of pharmaceuticals, drugs, and other chemicals. Nicotinic acid (vitamin B3) is an essential precursor for nicotinamide adenine dinucleotide (NAD+) biosynthesis and is vital for numerous metabolic processes. Since the human body cannot synthesize nicotinic acid, it relies on external sources. Therefore, nicotinic acid synthesis has gained huge attraction. In recent years, the industrial production of nicotinic acid has increasingly shifted from traditional chemical methods to more biocatalytic processes, leveraging the power of biocatalysts. This review highlights the biocatalyst-mediated synthesis of nicotinic-acid-and nitrile-metabolizing enzymes through state-of-the-art omics-based techniques to improve enzyme catalytic efficiency and stability via various approaches. Future research prospects and challenges associated with nicotinic acid production are also discussed.
Keywords: Biocatalysis, Biotransformation, Omics technology, Immobilization, Nitrilase
Received: 01 Mar 2025; Accepted: 19 May 2025.
Copyright: © 2025 Negi, KALIA, Sambyal, Singh, Kumar and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jung-Kul Lee, Department of Chemical Engineering, Konkuk University, Seoul, 143-701, Seoul, Republic of Korea
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