ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1629412
This article is part of the Research TopicBioengineering and Biotechnology Approaches in Cardiovascular Sciences, Volume IIIView all 3 articles
Laminin-derived peptide drives the cardiomyogenic potential and cardiac cells functionality
Provisionally accepted
Simona Casarella
Federica Ferla
Dalila Di Francesco
Veronica Pagani
Carolina Di Varsavia
Irene Regano
Francesca Boccafoschi*- Department of Health Sciences, University of Eastern Piedmont, Novara, Italy
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Laminin represents a major component of the basement membrane in cardiac tissue. Through integrins binding, laminin can sustain cell adhesion, proliferation, differentiation and mechanotransduction. The role of a small bioactive peptide (KKGSYNNIVVHV) derived from laminin in cardiac differentiation and functionality has been demonstrated. Briefly, results showed how the presence of laminin-derived peptide enhanced the differentiation of mesenchymal stem cells into cardiomyocytes-like phenotype, by modulating not only the cytoskeletal apparatus but also enhancing the cardiac and adhesion markers. Moreover, neonatal mouse cardiomyocytes in presence of the peptide showed well organized cytoskeletal rearrangements and regulated contractility. Therefore, in this study the role of lamininderived peptide in guiding cardiomyogenesis has been characterized, opening innovative approaches in functional cardiac tissue engineering and regenerative medicine.
Keywords: Laminin, cardiomyogenesis, Integrins, cardiac tissue engineering, Bioactive peptides
Received: 15 May 2025; Accepted: 11 Jul 2025.
Copyright: © 2025 Casarella, Ferla, Di Francesco, Pagani, Di Varsavia, Regano and Boccafoschi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Francesca Boccafoschi, Department of Health Sciences, University of Eastern Piedmont, Novara, Italy
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