SYSTEMATIC REVIEW article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
This article is part of the Research TopicEnhancing Sports Injury Management through Medical-Engineering InnovationsView all 23 articles
Platelet-Rich Plasma in Arthroscopic Rotator Cuff Repair: A Meta-Analysis of Biomaterial Efficacy and Future Directions for Personalized Sports Medicine
Provisionally accepted
- Changsha Hospital of Traditional Chinese Medicine, Changsha, China
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Background: Rotator cuff tears represent a prevalent musculoskeletal challenge with high postoperative retear rates despite surgical advances. Platelet-rich plasma (PRP) has emerged as a promising biological adjunct in arthroscopic repair, though clinical evidence remains inconsistent regarding its efficacy in improving structural and functional outcomes. Methods: This PRISMA-guided meta-analysis evaluated 13 randomized controlled trials (n=880 patients) comparing PRP-augmented versus conventional arthroscopic rotator cuff repair. Primary outcomes included retear rates and functional scores (UCLA, Constant, SST, ASES, VAS). Statistical analysis employed fixed/random-effects models with subgroup analyses of PRP formulations and tear characteristics. Results: PRP augmentation significantly improved functional outcomes, with mean differences of 1.82 points (95% CI: 1.13-2.51) for UCLA scores, 2.31 points (95% CI: 1.02-3.61) for Constant scores, and 0.43 points (95% CI: 0.11-0.75) for SST scores (all p<0.01). VAS pain scores decreased by 0.23 points (95% CI: -0.41 to -0.05, p=0.01). However, retear rates showed no significant reduction (RR=0.71, 95% CI: 0.48-1.05, p=0.09). Benefits were most pronounced in medium/large tears treated with leukocyte-poor PRP and double-row repairs (I²=0-40% for functional outcomes). Conclusions: While PRP enhances early functional recovery and pain control after rotator cuff repair, its capacity to improve structural integrity remains unproven. Clinical implementation requires standardization of PRP protocols and targeted application in patients with larger tears. Future research should investigate optimized biomaterial formulations and personalized treatment strategies.
Keywords: Platelet-Rich Plasma, Rotator cuff repair, Arthroscopy, Meta-analysis, Tendon healing
Received: 15 Jul 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Fan, Lu, Sun, Ying, Wang and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Donghua Fan
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