REVIEW article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Treatment of Diabetic wound Based on Hypoglycemic and Antioxidant
Provisionally accepted
- 1Shandong Second Medical University, Weifang, China
- 2Affiliated Hospital of Shandong Second Medical University, Weifang, China
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Diabetic ulcers are among the severe complications of diabetes. The accumulation of hyperglycemia and reactive oxygen species (ROS) in these ulcers significantly delays wound healing. Nanomedicine offers promising advantages for targeted drug delivery and enhanced therapeutic efficacy in treating diabetic ulcers associated with hyperglycemia and ROS. Effective treatment relies on the accessibility of suitable medications and wound dressings. This review summarizes current therapeutic strategies for diabetic skin injuries, focusing on two main categories: drugs (hypoglycemic agents and antioxidants) and drug delivery systems (hydrogels, nanofibers, and microneedle patches). By systematically analyzing these approaches, this review aims to inspire and guide the development of advanced nanomedicines for diabetic wound healing.
Keywords: antioxidant, Diabetic ulcers, Drug Delivery Systems, Hypoglycemic, Nanomedicines
Received: 15 Sep 2025; Accepted: 30 Nov 2025.
Copyright: © 2025 Li, Tan, Sun, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yingshuai Wang
Yong Zhang
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