ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomechanics
Construction of neural system disease models from the perspective of cellular biomechanics and their application in teaching practice
Provisionally accepted
- 1College of Second Clinical Medical of Guizhou University of Traditional Chinese Medicine, Guiyang, China
- 2The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China
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Background: Neurological diseases such as Alzheimer's, Parkinson's, and multiple sclerosis present significant challenges to healthcare systems due to their complex pathophysiological mechanisms. Recent advancements in cellular biomechanics have opened new avenues for modeling these diseases, providing insights into how mechanical forces influence cellular behavior and contribute to disease progression. Methods: This study explores the construction of neurological disease models from a cellular biomechanics perspective and their integration into educational practices. We combined biomechanical principles with traditional biological models to develop multiscale representations of neurological disorders, encompassing cellular, tissue, and organ levels. The models were applied in teaching through the design of interactive scenarios, including virtual simulations and 3D-printed anatomical structures, to promote active student engagement. Results: The integration of biomechanical models enhanced the understanding of disease mechanisms and facilitated the identification of key intervention targets. Teaching strategies incorporating these models improved student comprehension of neurological diseases, as evidenced by evaluation outcomes. The models also supported the development of personalized rehabilitation programs, demonstrating potential for clinical translation. Conclusion: The application of cellular biomechanics in neurological disease modeling enriches both research and educational practices. By bridging biomechanical insights with clinical and teaching applications, this approach prepares future healthcare professionals to address complex neurological disorders more effectively. Interdisciplinary collaboration among biomechanics, education, and clinical medicine is essential to advance neurological rehabilitation and improve patient outcomes.
Keywords: Neurological Diseases, Cellular biomechanics, disease models, Educational practices, Teaching strategies
Received: 29 Sep 2025; Accepted: 02 Dec 2025.
Copyright: © 2025 Xue, Zhao, Zhao, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hong Xue
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