REVIEW article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
This article is part of the Research TopicBiomaterials, 3D printing technologies, and perspectives for bone and cartilage regenerationView all 5 articles
3D-Printed Hip Prostheses with Regenerative Integration: A State-of-the-Art Comprehensive Review
Provisionally accepted
Sebastián Giraldo Gallego1,2*
Luis Eduardo Rodríguez Cheu1- 1Escuela Colombiana de Ingenieria Julio Garavito, Bogotá, Colombia
- 2Universidad Internacional de Valencia, Valencia, Spain
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This article offers an in-depth review of the design and modeling of 3D-printed hip prostheses, emphasizing the integration of regenerative medicine, especially in the context of custom RDOA implants. It traces the history of THA and current implant materials, along with recent advances in tissue engineering strategies and biofunctionalization methods to enhance biological integration. Computational processes are examined, including segmentation, image processing, CAD, FEA, and CAE simulations. It also discusses techniques in additive manufacturing that control porosity and stiffness, as well as strategies for recruiting host stem cells. The overall performance of existing THA approaches, combined with reliance on outdated surgical workflows and the complexity of clinical standards, creates challenges for the adoption of innovative implant research and limits broader application. International standards (ISO/ASTM), regional regulations (MDR, FDA), ethical considerations, and professional design guidelines are crucial components of this review, guiding safety, reproducibility, and the clinical impact of next-generation THA solutions. Finally, this review proposes a novel 'regenerative design' paradigm. Distinct from traditional biointegration methods, this framework integrates patient-specific imaging, mechanobiology-based architecture optimization, and biologically calibrated simulation to direct endogenous cell recruitment and vascularized healing explicitly.
Keywords: 3D printing, Biomaterials, Hematopoietic Stem Cells, Hip Prosthesis, simulation
Received: 07 Oct 2025; Accepted: 16 Dec 2025.
Copyright: © 2025 Giraldo Gallego and Rodríguez Cheu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sebastián Giraldo Gallego
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