REVIEW article
Front. Bioeng. Biotechnol.
Sec. Cell and Gene Therapy
Notch Signaling Pathway and Heart Development, Congenital Heart Disease, and Myocardial Regeneration
Provisionally accepted
- Zhengzhou University of Light Industry, Zhengzhou, China
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This review summarizes the critical role of the Notch signaling pathway in cardiac development, congenital heart disease, and myocardial regeneration. The Notch signaling pathway exerts a profound impact on cardiac health and disease progression by finely regulating the fate determination of cardiac progenitor cells, cardiac morphogenesis, and the proliferation and apoptosis of cardiomyocytes. The article also explores the research progress of the Notch signaling pathway as a potential therapeutic target and looks forward to future research directions.
Keywords: cardiac development, congenital heart disease, myocardial regeneration, Notch signaling pathway, Signal Transduction
Received: 24 Oct 2025; Accepted: 22 Dec 2025.
Copyright: © 2025 Liu, wang, Tao, Liu, li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Peifeng Li
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.