REVIEW article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
This article is part of the Research TopicAdvanced Hydrogels as Wound Dressings for Accelerated Wound HealingView all 4 articles
Carbon Nanotubes for Wound Healing: Material Design, Mechanistic Insights
Provisionally accepted
- 1Vellore Institute of Technology, Vellore, India
- 2Washington University in St Louis Center for Cellular Imaging, St. Louis, United States
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Chronic wounds such as diabetic ulcers remain significantly higher in global healthcare burden due to impaired angiogenesis, infection, and sustained inflammation. Carbon nanotubes (CNTs) are promising candidates for advanced wound-dressing applications due to their exceptional electrical conductivity, high mechanical strength, photothermal performance, and ease of surface modification. This review discusses recent progress in their functions in haemostasis, microbial protection, anti-inflammatory regulation, and tissue repair. We discussed research papers on CNT-based multifunctional hydrogels, electrospun scaffolds, and innovative dressings for bioactive agent delivery, electrical stimulation, and real-time monitoring of wound healing. We also discussed in vivo preclinical studies demonstrating significant re-epithelialization and increased angiogenesis, with accelerated wound closure in disease-impaired healing models, such as diabetes. Nevertheless, limitations such as cytotoxicity, impediments to scale-up manufacturing, and regulatory issues hinder direct clinical translation. To overcome these drawbacks, several approaches, such as chemical functionalization, biodegradable CNT derivatives, and hybrid nanocomposites, have been developed. Finally, we describe the translational path for CNT-based wound-healing applications and offer perspectives on future therapeutic interventions for chronic and complex wounds in the context of precision medicine.
Keywords: and scaffolds, Carbon nanotubes, conductive, Hydrogel, Wound Healing
Received: 25 Oct 2025; Accepted: 17 Dec 2025.
Copyright: © 2025 Poddar, NAIK and KUMARI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: SUSHMA KUMARI
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