ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Nanobiotechnology
This article is part of the Research TopicAdvanced nanotechnology for integrated diagnosis and treatmentView all articles
A Dynamically Tunable Terahertz Human Serum Albumin Biosensor based on Dirac semimetal nanozyme
Provisionally accepted
- 1Xiangtan Central Hospital, Xiangtan, China
- 2Central South University Forestry and Technology, Changsha, China
- 3Hunan Women's University, Changsha, China
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This study presents a tunable terahertz biosensor based on a hybrid architecture integrating bulk Dirac semimetal (BDS) with a photonic crystal for the label-free and highly sensitive detection of human serum albumin (HSA). The sensor exhibits a sharp Fano resonance resulting from the synergistic coupling between a defect mode and the BDS-mediated plasmonic response, with its resonance frequency being highly sensitive to variations in the refractive index of the sensing layer. Electric field simulations confirm significant field confinement and enhancement within the sensing region. The electrically tunable property of BDS allows dynamic reconfiguration of the sensor's sensitivity by adjusting the Fermi level (0.1-0.4 eV), though at the expense of a reduced figure of merit (FOM) due to broader resonance peaks and increased loss, necessitating a balance in practical implementations. Structural parameter analysis reveals that sensitivity is inversely proportional to the sensing layer thickness and gradually decreases with increasing refractive index. The proposed biosensor achieves a reflection dip deeper than 99% near 1 THz, with an angular sensitivity of 247.5°/RIU for minute refractive index changes (Δn = 0.002), demonstrating high sensitivity and excellent electrical tunability. This platform demonstrates pioneering potential in integrating diagnostic-treatment nanotechnology. Due to the powerful local field enhancement generated by the BDS photonic crystal heterostructure, the imaging sensitivity of the contrast agent based on nanoenzymes has been significantly improved. Moreover, the profound local field enhancement and dynamic tunability of this platform suggest its potential for real-time monitoring and regulation of the catalytic efficiency of nanoenzymes, which could address a fundamental challenge in therapeutic applications. Combined with its inherent biocompatibility and strong detection capabilities, this framework proposes a viable pathway toward the clinical translation of nanoenzyme technology. Our work thus establishes a foundational platform that paves the way for future multifunctional This is a provisional file, not the final typeset article theranostic systems capable of combining sensitive biomarker monitoring with enhanced therapeutic effects.
Keywords: optical biosensor, Human serum albumin, topological edge states, Graphene, Terahertz
Received: 31 Oct 2025; Accepted: 04 Dec 2025.
Copyright: © 2025 Chen, Yao, Chen, Peng, Xu and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuxiang Peng
Jiao Xu
Qiang Fu
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