BRIEF RESEARCH REPORT article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
This article is part of the Research TopicInsights into the manufacturing, storage and transport of therapies for regenerative medicine: Challenges and Changing perspectivesView all 8 articles
X-Ray Examination of Tissue-Engineered Epithelial Sheet during Transportation
Provisionally accepted
- ReMed Regenerative Medicine Clinical Application Institute, Shanghai, China
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Autologous tissue-engineered epithelial sheets (TEESs) are generally transported by dedicated couriers. The cost of this technology can be reduced by using cold-chain courier services, which the TEESs are subjected to x-rays during security checks. We exposed TEESs to a widely used x-ray luggage control system to the maximum dose limited by regional regulations. DNA fragmentation, unique variants by exome sequencing, proliferative capabilities were not altered after x-ray exposure. Thus, repeated exposure with x-ray radiation of luggage control systems did not induce changes in TEESs genetically or biologically, which should simplify the transport of grafts.
Keywords: Low Dose X-Ray Exposure, Safety of transportation, Tissue-Engineered Epithelial Sheet, Tissue-Engineered Grafts, X-ray irradiation
Received: 10 Dec 2025; Accepted: 11 Feb 2026.
Copyright: © 2026 Shao, Wu and Tan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zheng Lin Tan
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