Frontiers in Bioengineering and Biotechnology

Original Research

Published on 09 Jan 2023

Diosgenin enhances liposome-enabled nucleic acid delivery and CRISPR/Cas9-mediated gene editing by modulating endocytic pathways

in Cell and Gene Therapy

Brijesh Lohchania
Abisha Crystal Christopher
Porkizhi Arjunan
Gokulnath Mahalingam
Durga Kathirvelu
Aishwarya Prasannan
Vigneshwaran Venkatesan
Pankaj Taneja
Mohan Kumar KM
Saravanabhavan Thangavel

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.1031049

2,975 views
3 citations

Original Research

Published on 04 Jan 2023

Platelet-rich plasma attenuates the severity of joint capsule fibrosis following post-traumatic joint contracture in rats

in Cell and Gene Therapy

Yuxin Zhang
Zengguang Wang
Chenyu Zong
Xiaoding Gu
Shuai Fan
Lili Xu
Bin Cai
Shenji Lu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.1078527

3,629 views
12 citations

Original Research

Published on 19 Dec 2022

Novel assay to measure chromosome instability identifies Punica granatum extract that elevates CIN and has a potential for tumor- suppressing therapies

in Cell and Gene Therapy

Nikolay V. Goncharov
Valeria A. Kovalskaia
Alexander O. Romanishin
Nikita A. Shved
Andrei S. Belousov
Vladlena S. Tiasto
Valeriia S. Gulaia
Vidushi S. Neergheen
Nawraj Rummun
Mikhail Liskovykh

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.989932

2,405 views
2 citations

Systematic Review

Published on 16 Dec 2022

Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke

in Cell and Gene Therapy

Meiqi Jin
Shuxia Zhang
Mengchen Wang
Qiaoyu Li
Jiahui Ren
Yun Luo
Xiaobo Sun

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.980548

6,373 views
11 citations

Editorial

Published on 09 Dec 2022

Editorial: Current approaches to CRISPR/Cas9 delivery

in Cell and Gene Therapy

Hasan Uludağ
Hamidreza Montazeri Aliabadi
Giedrius Gasiunas

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.1103007

2,285 views

Original Research

Published on 09 Dec 2022

Placental stem cells-derived exosomes stimulate cutaneous wound regeneration via engrailed-1 inhibition

in Cell and Gene Therapy

Yan Zhang
Liyan Shi
Xiuying Li
Yang Liu
Guokun Zhang
Yimin Wang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.1044773

4,858 views
18 citations

Original Research

Published on 06 Dec 2022

Modeling cartilage pathology in mucopolysaccharidosis VI using iPSCs reveals early dysregulation of chondrogenic and metabolic gene expression

in Cell and Gene Therapy

M. Broeders
Jgj van Rooij
E. Oussoren
Tjm van Gestel
Ca Smith
Sj Kimber
Rm Verdijk
Maem Wagenmakers
Jmp van den Hout
At van der Ploeg

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.949063

2,511 views
4 citations

Original Research

Published on 05 Dec 2022

Screening for MicroRNA combination with engineered exosomes as a new tool against osteosarcoma in elderly patients

in Cell and Gene Therapy

Jiyu Han
Zitong Zhao
Yanhong Wang
Tao Yu
Daqian Wan

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.1052252

2,363 views
2 citations

Review

Published on 25 Nov 2022

A new frontier in temporomandibular joint osteoarthritis treatment: Exosome-based therapeutic strategy

in Cell and Gene Therapy

Wenxiu Yuan
Yange Wu
Maotuan Huang
Xueman Zhou
Jiaqi Liu
Yating Yi
Jun Wang
Jin Liu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.1074536

9,842 views
16 citations

Editorial

Published on 22 Nov 2022

Editorial: Gene therapy 2.0: Biotechnology for circuit engineering and complex therapeutic approaches

in Cell and Gene Therapy

Luís Quintino
Luís Pereira de Almeida
Cecilia Lundberg

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.1082883

2,035 views

Review

Published on 22 Nov 2022

CRISPR/Cas systems: Delivery and application in gene therapy

in Cell and Gene Therapy

Jie Huang
Yitong Zhou
Jie Li
Aiping Lu
Chao Liang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.942325

19,081 views
49 citations

Methods

Published on 21 Nov 2022

Optimization of chondrocyte isolation from human articular cartilage to preserve the chondrocyte transcriptome

in Cell and Gene Therapy

Ping Shen
Peihua Wu
Tazio Maleitzke
Marie-Jacqueline Reisener
Gitta A. Heinz
Frederik Heinrich
Pawel Durek
Clemens Gwinner
Tobias Winkler
Matthias Pumberger

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.1046127

4,505 views
4 citations

Original Research

Published on 17 Nov 2022

Evaluation of unsulfated biotechnological chondroitin in a knee osteoarthritis mouse model as a potential novel functional ingredient in nutraceuticals and pharmaceuticals

in Cell and Gene Therapy

Donatella Cimini
Serena Boccella
Alberto Alfano
Antonietta Stellavato
Salvatore Paino
Chiara Schiraldi
Francesca Guida
Michela Perrone
Maria Donniacuo
Virginia Tirino

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.934997

3,712 views
7 citations

Review

Published on 14 Nov 2022

Future perspective of stem cell-derived exosomes: Cell-free therapeutic strategies for retinal degeneration

in Cell and Gene Therapy

Zibin Liu
Fang Zeng
Yao Zhang
Yongqing Liu
Zhuo Li
Xiao Liu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.905516

5,560 views
3 citations

Original Research

Published on 10 Nov 2022

Efficient multitool/multiplex gene engineering with TALE-BE

in Cell and Gene Therapy

Alex Boyne
Ming Yang
Sylvain Pulicani
Maria Feola
Diane Tkach
Robert Hong
Aymeric Duclert
Philippe Duchateau
Alexandre Juillerat

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.1033669

6,326 views
5 citations

Original Research

Published on 08 Nov 2022

The inhibitory effect of human umbilical cord mesenchymal stem cells expressing anti-HAAH scFv-sTRAIL fusion protein on glioma

in Cell and Gene Therapy

Tian Xue
Xiaolin Wang
Jing Ru
Lixing Zhang
Huancai Yin

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.997799

2,201 views
1 citation