Frontiers in Bioinformatics | Integrative Bioinformatics

Correction

Accepted on 21 Nov 2025

Correction: Integrative Machine Learning and Bioinformatics Analysis to Identify Cellular Senescence-Related Genes and Potential Therapeutic Targets in Ulcerative Colitis and Colorectal Cancer

in Integrative Bioinformatics

Tianle Xue
Yunpeng Chen
Xiaomeng Li
Zhixiang Zhou
Qiyang Chen

Frontiers in Bioinformatics

Original Research

Accepted on 10 Nov 2025

Neurogenic locus notch homolog protein 1 (Notch1) SNP informatics coupled with Intrinsically Disordered Region and Post Translational Modifications reveals the complex structural crosstalk of Lung Adenocarcinoma (LUAD)

in Integrative Bioinformatics

Pearl John
Sudandiradoss C

Frontiers in Bioinformatics

161 views

Original Research

Accepted on 06 Nov 2025

Predicting GD2 expression across cancer types by the integration of pathway topology and transcriptome data

in Integrative Bioinformatics

Arsenij Ustjanzew
Federico Marini
Saskia Wagner
Arthur Wingerter
Roger Sandhoff
Jörg Faber
Claudia Paret

Frontiers in Bioinformatics

221 views

Original Research

Published on 03 Nov 2025

Identification of ordinal relations and alternative suborders within high-dimensional molecular data

in Integrative Bioinformatics

Ana Stolnicu
Peter Eckhardt-Bellmann
Angelika M. R. Kestler
Hans A. Kestler

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1665892

658 views

Original Research

Published on 22 Oct 2025

Inferred global dense residue transition graphs from primary structure sequences enable protein interaction prediction via directed graph convolutional neural networks

in Integrative Bioinformatics

Islam Akef Ebeid
Haoteng Tang
Pengfei Gu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1651623

981 views

Original Research

Accepted on 20 Oct 2025

Identification of Multiple Prognostic Biomarker Sets for Risk Stratification in SKCM

in Integrative Bioinformatics

Shivani Malik
Ritu Tomer
Akanksha Arora
Gajendra PS Raghava

Frontiers in Bioinformatics

157 views

Original Research

Published on 15 Oct 2025

Multimodal knowledge expansion widget powered by plant protein phosphorylation database and ChatGPT

in Integrative Bioinformatics

Chunhui Xu
Yang Yu
Govardhan Khadakkar
Jiacheng Xie
Dong Xu
Qiuming Yao

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1687687

1,106 views

Brief Research Report

Published on 02 Oct 2025

Optimizing clustering of CDR3 sequences using natural language processing, Word2Vec, and KMeans

in Integrative Bioinformatics

Sanskriti Baranwal
Ricardo Avila Sanchez
Clement-Andi Edet
Erick Chastain
Inimary Toby

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1623488

1,545 views

Technology and Code

Published on 30 Sep 2025

EPheClass: ensemble-based phenotype classifier from 16S rRNA gene sequences

in Integrative Bioinformatics

Lara Vázquez-González
Carlos Peña-Reyes
Alba Regueira-Iglesias
Carlos Balsa-Castro
Inmaculada Tomás
María J. Carreira

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1514880

1,060 views

Original Research

Published on 22 Sep 2025

Extracting a COVID-19 signature from a multi-omic dataset

in Integrative Bioinformatics

Baptiste Bauvin
Thibaud Godon
Guillaume Bachelot
Claudia Carpentier
Riikka Huusaari
Maxime Deraspe
Juho Rousu
Caroline Quach
Jacques Corbeil

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1645785

1,311 views

Original Research

Published on 19 Sep 2025

Identification and therapeutic investigation of biomarker genes underpinning hepatocellular carcinoma: an in silico study utilising molecular docking and dynamics simulation

in Integrative Bioinformatics

Jishnu Ghosh
Abdullah M. Alshahrani
Aritra Palodhi
Debarghya Bhattacharyya
Subhadip Das
Sunil Kanti Mondal
Abul Kalam
S. Rehan Ahmad
Chittabrata Mal

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1567748

2,090 views

Original Research

Published on 19 Sep 2025

Integrated multi-optosis model for pan-cancer candidate biomarker and therapy target discovery

in Integrative Bioinformatics

Emanuell Rodrigues de Souza
Higor Almeida Cordeiro Nogueira
Ronaldo da Silva Francisco Junior
Ana Beatriz Garcia
Enrique Medina-Acosta

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1630518

1,728 views
2 citations

Original Research

Published on 18 Sep 2025

Key genes associated with brain metastasis in non-small cell lung cancer: novel insights from bioinformatics analysis

in Integrative Bioinformatics

Shuang Zhao
He Zhang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1625664

1,955 views

Original Research

Published on 18 Sep 2025

BC-predict: mining of signal biomarkers and production of models for early-stage breast cancer subtyping and prognosis

in Integrative Bioinformatics

Sangeetha Muthamilselvan
Natarajan Vaithilingam
Ashok Palaniappan

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1644695

1,707 views
1 citation

FAIR² Data

Published on 08 Sep 2025

Structure-based prediction of SARS-CoV-2 variant properties using machine learning on mutational neighborhoods

in Integrative Bioinformatics

Max van den Boom
Erik Schultes
Thomas Hankemeier

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1634111

2,515 views

Methods

Published on 04 Sep 2025

A novel linear indexing method for strings under all internal nodes in a suffix tree

in Integrative Bioinformatics

Anas Al-okaily
Abdelghani Tbakhi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1577324

838 views