Frontiers in Bioinformatics | Integrative Bioinformatics

Perspective

Published on 15 May 2026

Using user-centered design to better understand challenges faced during genetic analyses by novice genomic researchers

in Integrative Bioinformatics

Harsh Vijaykumar Patel
Gail P. Jarvik
Taryn O. Hall
David L. Veenstra
Serena Jinchen Xie
David R. Crosslin

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1849524

159 views

Original Research

Published on 13 May 2026

Predicting anthropometric body composition variables using 3D optical imaging and machine learning

in Integrative Bioinformatics

Gyaneshwar Agrahari
Kiran Bist
Monika Pandey
Jacob Kapita
Zachary James
Jackson Knox
Steven Heymsfield
Sophia Ramirez
Peter Wolenski
Nadejda Drenska

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1722578

363 views

Original Research

Accepted on 11 May 2026

Integrative Phosphoproteomic Analysis Identifies Functional Roles of TRPM7 Phosphosites in Oncogenesis

in Integrative Bioinformatics

Akhina Palollathil
Althaf Mahin
Athira Perunelly Gopalakrishnan
Alimath Sambreena
PRATHIK B S
Rajesh Raju

Frontiers in Bioinformatics

Original Research

Accepted on 11 May 2026

Real-world chronic recordings from implantable adaptive deep brain stimulation systems for Parkinson's Disease Motor State Classification

in Integrative Bioinformatics

Hanan Awad Hassan Ali
Matteo Guidetti
Laura Caffi
Mattia Arlotti
Lorenzo Rossi
Chiara Palmisano
Alberto Priori
Francesco Brun
Ioannis Ugo Isaias
Sara Marceglia

Frontiers in Bioinformatics

Original Research

Accepted on 11 May 2026

Polygenic modeling of genetic effects on both phenotypic mean and variance: Distributional regression for BMI, blood and urine biomarkers in the UK Biobank

in Integrative Bioinformatics

Kiran Kunwar
Qiong Wu
Hannah Klinkhammer
Christian Staerk
Andreas Mayr
Carlo Maj

Frontiers in Bioinformatics

Original Research

Accepted on 07 May 2026

Machine Learning-Based Classification of COVID-19 Severity Using Respiratory Microbiome Profiles from Shotgun Metagenomic Sequencing

in Integrative Bioinformatics

Eli Gabriel Avina-Bravo
Isabel Gracía-Lorenzo
Mariel Alfaro-Ponce
Luz Breton-Deval

Frontiers in Bioinformatics

156 views

Original Research

Published on 07 May 2026

Comparative transcriptomics and computational drug discovery identify ASPM as a key oncogenic driver and therapeutic target in hepatocellular carcinoma

in Integrative Bioinformatics

Pan Li
Aiye Guo
MingJing Zhao
GuangHui Chen

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1795889

375 views

Review

Accepted on 04 May 2026

Resources and applications of public biomedical data

in Integrative Bioinformatics

Liu Mingrui
Zelin Ye
Haiyu Liu
Pengzhen Ma
Huaxin Pang
Yaning Li
Qihao Wang
Yikang Shen
Xiaoxia Xie
Yufeng Zhao

Frontiers in Bioinformatics

161 views

Original Research

Published on 04 May 2026

Delineating novel diagnostic biomarkers and therapeutic targets for oral submucosal fibrosis: an integrative multi-omics and machine learning approach

in Integrative Bioinformatics

Chinmay Nitin Mokal
Piyush Agrawal

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1803111

453 views

Original Research

Published on 01 May 2026

On the optimization of copy number variations representation in pangenome graphs

in Integrative Bioinformatics

Mirko Coggi
Lorenzo Basile
Beatrice Branchini
Gabriele Amodeo
Guido Walter Di Donato
Marco D. Santambrogio

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1811916

613 views

Correction

Published on 30 Apr 2026

Correction: An integrated automated deep learning framework for annotating tumor-infiltrating lymphocytes in lung adenocarcinoma pathology

in Integrative Bioinformatics

Xia Li
Kang-Lai Wei
Zhao-Quan Huang
Zi-Yan Huang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1841924

338 views

Original Research

Accepted on 29 Apr 2026

A Vasculogenic Mimicry Subtype Unveiled by Integrated Multi-Omics Predicts Prognosis and Guides Immunotherapy in MIBC

in Integrative Bioinformatics

Luqing Wei
Shuzhen Liao
Xin Feng
Zhenyou Tang
Zhenyu Tang
Yuting Tao
Youwen Zheng
Tao Liu
Zezu Qin
Xuancheng Cao

Frontiers in Bioinformatics

187 views

Original Research

Accepted on 29 Apr 2026

Sparse time-varying log-ratios for longitudinal high-throughput sequencing data

in Integrative Bioinformatics

Ruijin Lu
Guoqi Yu
Cuilin Zhang
Zhen Chen

Frontiers in Bioinformatics

148 views

Original Research

Published on 29 Apr 2026

Comprehensive genomics, systems, and structural assessment for novel target identification in penicillin-resistant Streptococcus pneumoniae

in Integrative Bioinformatics

Avani Panickar
Suvitha Anbarasu
Anand Manoharan
Sudha Ramaiah
Anand Anbarasu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1784287

446 views

Original Research

Accepted on 28 Apr 2026

Harnessing Cutting-Edge Techniques to Identify Novel Gene Expression Signatures in Acute Myeloid Leukemia patients

in Integrative Bioinformatics

Adriana Blanda
Rebecca Manitto
Sabina Sangaletti
Paolo Verderio

Frontiers in Bioinformatics

165 views

Technology and Code

Accepted on 27 Apr 2026

QUERCUSTOA: Integrating functional annotations and comparative genomics across oak lineages

in Integrative Bioinformatics

Unai López De Heredia
Fernando Mora-Márquez
Mikel Hurtado

Frontiers in Bioinformatics

180 views

Original Research

Accepted on 27 Apr 2026

Practical guidelines for Multiple Instance Learning in computational pathology: how embedding choice impacts overall survival prediction

in Integrative Bioinformatics

Francesca Miccolis
Elisa Ficarra
Marta Lovino

Frontiers in Bioinformatics

240 views

Original Research

Published on 23 Apr 2026

Public health risk stratification using hybrid machine learning: a reproducible analysis of performance, stability, and risk attribution

in Integrative Bioinformatics

Alejandro Cabrera-Andrade
Ana Karina Zambrano
Joselin García-Ortiz
William Villegas-Ch

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1803572

522 views

Original Research

Published on 22 Apr 2026

How benchmarking of bioinformatics tools is essential for informed workflow selection: a case study on SARS-CoV-2 subgenomic RNA detection

in Integrative Bioinformatics

Gabriele Leoni
Mauro Petrillo
Man-Hung Eric Tang
Soren Alexandersen

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1803237

494 views

Original Research

Accepted on 20 Apr 2026

Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer's disease progression

in Integrative Bioinformatics

María Andrea Angarita Rodríguez
Viviana Vargas López
Andres Mauricio Pinzón
Adran Sandoval Hernandez
Kai Kang
Leping Li
Jason Papin
Pedro Puentes Rozo
Andres Felipe Aristizabal-Pachon
Janneth Gonzalez

Frontiers in Bioinformatics

309 views

Original Research

Published on 20 Apr 2026

Feature representation for explainable CRISPR off-target prediction and base editing efficiency

in Integrative Bioinformatics

Faiza Hasin
Michele Minervini
Corrado Mencar
Giuseppe Ventrella
Arianna Consiglio
Alessandro Orro
Tommaso Selmi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1800237

568 views

Original Research

Published on 17 Apr 2026

Geometric multidimensional representation of omic signatures

in Integrative Bioinformatics

Higor Almeida Cordeiro Nogueira
Enrique Medina-Acosta

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1806975

465 views

Original Research

Published on 14 Apr 2026

Self-organizing maps for allele specific expression data reconstruction and identification of anomalous genomic regions

in Integrative Bioinformatics

Roberto Pagliarini
Francesco Nascimben
Alberto Policriti

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1810835

385 views

Correction

Published on 13 Apr 2026

Correction: Human-associated NDM-5-producing multidrug-resistant Escherichia coli detected in retail beef and pork in Hungary, 2021

in Integrative Bioinformatics

Frontiers Production Office

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1842628

304 views

121 articles

articles

Using user-centered design to better understand challenges faced during genetic analyses by novice genomic researchers

Predicting anthropometric body composition variables using 3D optical imaging and machine learning

Integrative Phosphoproteomic Analysis Identifies Functional Roles of TRPM7 Phosphosites in Oncogenesis

Real-world chronic recordings from implantable adaptive deep brain stimulation systems for Parkinson's Disease Motor State Classification

Polygenic modeling of genetic effects on both phenotypic mean and variance: Distributional regression for BMI, blood and urine biomarkers in the UK Biobank

Machine Learning-Based Classification of COVID-19 Severity Using Respiratory Microbiome Profiles from Shotgun Metagenomic Sequencing

Comparative transcriptomics and computational drug discovery identify ASPM as a key oncogenic driver and therapeutic target in hepatocellular carcinoma

Resources and applications of public biomedical data

Delineating novel diagnostic biomarkers and therapeutic targets for oral submucosal fibrosis: an integrative multi-omics and machine learning approach

On the optimization of copy number variations representation in pangenome graphs

Correction: An integrated automated deep learning framework for annotating tumor-infiltrating lymphocytes in lung adenocarcinoma pathology

A Vasculogenic Mimicry Subtype Unveiled by Integrated Multi-Omics Predicts Prognosis and Guides Immunotherapy in MIBC

Sparse time-varying log-ratios for longitudinal high-throughput sequencing data

Comprehensive genomics, systems, and structural assessment for novel target identification in penicillin-resistant Streptococcus pneumoniae

Harnessing Cutting-Edge Techniques to Identify Novel Gene Expression Signatures in Acute Myeloid Leukemia patients

QUERCUSTOA: Integrating functional annotations and comparative genomics across oak lineages

Practical guidelines for Multiple Instance Learning in computational pathology: how embedding choice impacts overall survival prediction

Public health risk stratification using hybrid machine learning: a reproducible analysis of performance, stability, and risk attribution

How benchmarking of bioinformatics tools is essential for informed workflow selection: a case study on SARS-CoV-2 subgenomic RNA detection

Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer's disease progression

Feature representation for explainable CRISPR off-target prediction and base editing efficiency

Geometric multidimensional representation of omic signatures

Self-organizing maps for allele specific expression data reconstruction and identification of anomalous genomic regions

Correction: Human-associated NDM-5-producing multidrug-resistant Escherichia coli detected in retail beef and pork in Hungary, 2021