Frontiers in Bioinformatics

Original Research

Published on 26 Aug 2025

Identifying novel therapeutic targets for non-alcoholic fatty liver disease using bioinformatics approaches: from drug repositioning to traditional Chinese medicine

Jingmin Zhang
Tianwei Meng
Weiqi Gao
Xinghua Li
Juan Xu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1613985

528 views

Technology and Code

Accepted on 25 Aug 2025

TCRscape: A Single-Cell Multi-Omic TCR Profiling Toolkit

Roman Perik-Zavodskii
Olga Perik-Zavodskaia
Marina Volynets
Saleh Alrhmoun
Sergey Vital'evich Sennikov

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1641491

Review

Accepted on 22 Aug 2025

Segmentation and Modeling of Large-Scale Microvascular Networks: A Survey

Helya Goharbavang
Artem T Ashitkov
Athira Pillai
Joshua D Wythe
Guoning Chen
David Mayerich

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1645520

152 views

Editorial

Accepted on 22 Aug 2025

Editorial: Networks and Graphs in Biological Data: Current Methods, Opportunities and Challenges

Derek L. Thompson
Hsiang-Yun Wu
Christopher W Bartlett
William C Ray

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1685992

255 views

Original Research

Published on 20 Aug 2025

Using reinforcement learning in genome assembly: in-depth analysis of a Q-learning assembler

Kleber Padovani
Rafael Cabral Borges
Roberto Xavier
André Carlos Carvalho
Anna Reali
Annie Chateau
Ronnie Alves

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1633623

779 views

Original Research

Published on 20 Aug 2025

Novel deep learning for multi-class classification of Alzheimer’s in disability using MRI datasets

Sumaiya Binte Shahid
Maleeha Kaikaus
Md. Hasanul Kabir
Mohammad Abu Yousuf
A. K. M. Azad
A. S. Al-Moisheer
Naif Alotaibi
Salem A. Alyami
Touhid Bhuiyan
Mohammad Ali Moni

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1567219

864 views

Original Research

Accepted on 19 Aug 2025

Unveiling the impact of interferon genes on the immune microenvironment of triple-negative breast cancer: identification of therapeutic targets

Ying Liu
Jiayi Cai
Kai Zhuang
Lin Yan
Yong Liu
Jiaojiao Wang
Yulai Tang
Defang Ouyang
Zunnan Huang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1629526

322 views

Original Research

Published on 18 Aug 2025

Spatial heterogeneity reveals an evolutionary signature predicting therapeutic response and clinical outcomes in hepatocellular carcinoma

Shangyi Luo
Li Liu
Yang Sun
Jian Shi
Yajing Zhang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1669236

597 views

Original Research

Accepted on 15 Aug 2025

Identification and therapeutic investigation of biomarker genes underpinning hepatocellular carcinoma: An in-silico study utilising molecular docking and dynamics simulation

Jishnu Ghosh
Dr Abdullah Alshahrani
Aritra Palodhi
Debarghya Bhattacharyya
Subhadip Das
Sunil Kanti Mondal
Abul Kalam
S Rehan Ahmad
Dr. Chittabrata Mal

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1567748

255 views

Brief Research Report

Published on 15 Aug 2025

DIAMOND2GO: rapid Gene Ontology assignment and enrichment detection for functional genomics

Christopher Golden
David J. Studholme
Rhys A. Farrer

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1634042

621 views

Brief Research Report

Published on 14 Aug 2025

Precision medicine on a budget in Africa: using existing genetic data to mitigate adverse drug reactions to conventional cancer drugs

Alexandra Lindsey Djomkam Zune
Charles Ochieng’ Olwal
Emmanuel Agbeli
Abdoulaye Baniré Diallo
Emmanuella Amoako
Yaw Bediako
Lily Paemka

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1555637

653 views

Original Research

Published on 14 Aug 2025

Stain-free artificial intelligence-assisted light microscopy for the identification of blood cells in microfluidic flow

Alexander Hunt
Holger Schulze
Kay Samuel
Robert B. Fisher
Till T. Bachmann

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1628724

742 views

Original Research

Accepted on 13 Aug 2025

Extracting a COVID-19 Signature from a Multi-Omic Dataset

Baptiste Bauvin
Thibaud Godon
Guillaume Bachelot
Claudia Carpentier
Riikka Huusari
Maxime Deraspe
Juho Rousu
Caroline Quach
Jacques Corbeil

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1645785

297 views

Original Research

Accepted on 12 Aug 2025

BC-Predict: Mining of signal biomarkers and production of models for early-stage breast cancer subtyping and prognosis

Sangeetha Muthamilselvan
Natarajan Vaithilingam
Ashok Palaniappan

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1644695

285 views

Original Research

Published on 12 Aug 2025

Sequence-based prioritization of i-Motif candidates in the human genome

Veronica Remori
Michela Prest
Mauro Fasano

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1657841

499 views

Original Research

Accepted on 11 Aug 2025

COCαDA - A Fast and Scalable Algorithm for Interatomic Contact Detection in Proteins Using Cα Distance Matrices

Rafael Pereira Lemos
Diego Mariano
Sabrina de Azevedo Silveira
Raquel Cardoso de Melo-Minardi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1630078

221 views

503 Publications

Volume 5 - 2025

Identifying novel therapeutic targets for non-alcoholic fatty liver disease using bioinformatics approaches: from drug repositioning to traditional Chinese medicine

TCRscape: A Single-Cell Multi-Omic TCR Profiling Toolkit

Segmentation and Modeling of Large-Scale Microvascular Networks: A Survey

Editorial: Networks and Graphs in Biological Data: Current Methods, Opportunities and Challenges

Using reinforcement learning in genome assembly: in-depth analysis of a Q-learning assembler

Novel deep learning for multi-class classification of Alzheimer’s in disability using MRI datasets

Unveiling the impact of interferon genes on the immune microenvironment of triple-negative breast cancer: identification of therapeutic targets

Spatial heterogeneity reveals an evolutionary signature predicting therapeutic response and clinical outcomes in hepatocellular carcinoma

Identification and therapeutic investigation of biomarker genes underpinning hepatocellular carcinoma: An in-silico study utilising molecular docking and dynamics simulation

DIAMOND2GO: rapid Gene Ontology assignment and enrichment detection for functional genomics

Precision medicine on a budget in Africa: using existing genetic data to mitigate adverse drug reactions to conventional cancer drugs

Stain-free artificial intelligence-assisted light microscopy for the identification of blood cells in microfluidic flow

Extracting a COVID-19 Signature from a Multi-Omic Dataset

BC-Predict: Mining of signal biomarkers and production of models for early-stage breast cancer subtyping and prognosis

Sequence-based prioritization of i-Motif candidates in the human genome

COCαDA - A Fast and Scalable Algorithm for Interatomic Contact Detection in Proteins Using Cα Distance Matrices