Frontiers in Bioinformatics

Original Research

Published on 04 Nov 2025

Cellf-deception: human microglia clone 3 (HMC3) cells exhibit more astrocyte-like than microglia-like gene expression

Kylee K. Rahm
Branden S. Kinghorn
Myanna J. Moody
Ben C. Stone
Kenton C. Strong
Brian S. Kim
Yen Jou Chang
Samantha N. Sleight
Alyssa A. Nitz
David V. Hansen

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1681811

343 views

Original Research

Published on 03 Nov 2025

Identification of ordinal relations and alternative suborders within high-dimensional molecular data

Ana Stolnicu
Peter Eckhardt-Bellmann
Angelika M. R. Kestler
Hans A. Kestler

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1665892

438 views

Brief Research Report

Accepted on 31 Oct 2025

Computational Analysis of Transcriptome Data and Mapping of Functional Networks in Parkinson's Disease

Marios Krokidis
Konstantinos Perperidis
Themis Exarchos
Aristidis G. Vrahatis
PANAGIOTIS VLAMOS

Frontiers in Bioinformatics

Review

Published on 31 Oct 2025

Segmentation and modeling of large-scale microvascular networks: a survey

Helya Goharbavang
Artem T. Ashitkov
Athira Pillai
Joshua D. Wythe
Guoning Chen
David Mayerich

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1645520

582 views

Editorial

Published on 31 Oct 2025

Editorial: Computational protein function prediction based on sequence and/or structural data

Yaan J. Jang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1705252

680 views

Original Research

Accepted on 30 Oct 2025

A Novel and Accelerated Method for Integrated Alignment and Variant Calling from Short and Long Reads

Jinnan Hu
Donald Freed
Hanying Feng
Hong Chen
Zhipan Li
Haodong Chen

Frontiers in Bioinformatics

311 views

Perspective

Published on 30 Oct 2025

The importance of democratized resources in early-career training for bioimage analysts and bioimaging scientists

Genevieve Laprade
Quinn Lee
Kristin L. Gallik
Michael Nelson
Natalie Woo
Celina Terán Ramírez
Alexis Ricardo Becerril Cuevas
Kevin W. Eliceiri
Corinne Esquibel

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1693343

516 views

Original Research

Accepted on 29 Oct 2025

Genomics-Driven Drug Repurposing and Novel Targets Identification for Sickle Cell Disease in Saudi Patients

Mohammad A. Alshabeeb
Ali Alghubayshi
Dayanjan S Wijesinghe
Mohammed Alawadh
Suad Alshammari
Khalifa Alrajeh
Mona A Alkhairi
Imadul Islam

Frontiers in Bioinformatics

Original Research

Published on 29 Oct 2025

Gene expression profile in colon cancer therapeutic resistance and its relationship with the tumor microenvironment

Priscila Galvão Doria
Gisele Vieira Rocha
Vanessa Dybal Bertoni
Roberto de Souza Batista dos Santos
Mariana Araújo-Pereira
Clarissa Gurgel

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1674179

493 views

Original Research

Accepted on 28 Oct 2025

Food-Derived Linear vs. Rationally Designed Cyclic Peptides as Potent TNF-alpha Inhibitors: An Integrative Computational Study

Manisha Shah
Sivakumar Arumugam

Frontiers in Bioinformatics

Technology and Code

Accepted on 27 Oct 2025

Bacteriocin Prediction Through Cross-Validation-Based and Hypergraph-Based Feature Evaluation Approaches

Suraiya Akhter
John Miller

Frontiers in Bioinformatics

185 views

Original Research

Accepted on 27 Oct 2025

Identification and Validation of Tumor Microenvironment-Related Therapeutic Targets in Gastric Cancer Using Integrated Multi-Omics and Molecular Docking Approaches

Mohamed Kalith Oli M
JAFAR ALI IBRAHIM

Frontiers in Bioinformatics

197 views

Original Research

Accepted on 27 Oct 2025

QSAR-Guided Discovery of Novel KRAS Inhibitors for Lung Cancer Therapy

Osasan Stephen Adebayo
Oche Ambrose George
Daramola Olusola
Adefolalu Oluwafemi
Hind A. Alzahrani
Abdulkarim Hasan

Frontiers in Bioinformatics

134 views

Original Research

Accepted on 24 Oct 2025

Subtractive Genomic Approach to Uncover Novel Drug Targets in Salmonella typhimurium and Computational Screening of Food-Based Polyphenols as Inhibitors

Mohammed Naveez Valathoor
Subhashree Venugopal
Anand Prem Rajan

Frontiers in Bioinformatics

389 views

Perspective

Published on 24 Oct 2025

Why science needs art

Giulia Ghisleni
Christian Stolte
Megan Gozzard
Lea Von Soosten
Antonia Bruno

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1708311

454 views

Original Research

Published on 24 Oct 2025

Unraveling the molecular basis of snake venom nerve growth factor: human TrkA recognition through molecular dynamics simulation and comparison with human nerve growth factor

Shrudhi Devi
Gurunathan Jayaraman

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1674791

521 views

543 Publications

Volume 5 - 2025

Cellf-deception: human microglia clone 3 (HMC3) cells exhibit more astrocyte-like than microglia-like gene expression

Identification of ordinal relations and alternative suborders within high-dimensional molecular data

Computational Analysis of Transcriptome Data and Mapping of Functional Networks in Parkinson's Disease

Segmentation and modeling of large-scale microvascular networks: a survey

Editorial: Computational protein function prediction based on sequence and/or structural data

A Novel and Accelerated Method for Integrated Alignment and Variant Calling from Short and Long Reads

The importance of democratized resources in early-career training for bioimage analysts and bioimaging scientists

Genomics-Driven Drug Repurposing and Novel Targets Identification for Sickle Cell Disease in Saudi Patients

Gene expression profile in colon cancer therapeutic resistance and its relationship with the tumor microenvironment

Food-Derived Linear vs. Rationally Designed Cyclic Peptides as Potent TNF-alpha Inhibitors: An Integrative Computational Study

Bacteriocin Prediction Through Cross-Validation-Based and Hypergraph-Based Feature Evaluation Approaches

Identification and Validation of Tumor Microenvironment-Related Therapeutic Targets in Gastric Cancer Using Integrated Multi-Omics and Molecular Docking Approaches

QSAR-Guided Discovery of Novel KRAS Inhibitors for Lung Cancer Therapy

Subtractive Genomic Approach to Uncover Novel Drug Targets in Salmonella typhimurium and Computational Screening of Food-Based Polyphenols as Inhibitors

Why science needs art

Unraveling the molecular basis of snake venom nerve growth factor: human TrkA recognition through molecular dynamics simulation and comparison with human nerve growth factor