Frontiers in Bioinformatics

Original Research

Accepted on 07 Aug 2025

Identifying Novel Therapeutic Targets for Non-Alcoholic Fatty Liver Disease Using Bioinformatics Approaches: From Drug Repositioning to Traditional Chinese Medicine

Jingmin Zhang
Tianwei Meng
Weiqi Gao
Xinghua Li
Juan Xu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1613985

Methods

Accepted on 07 Aug 2025

A Novel Linear Indexing for Strings under all Internal Nodes in a Suffix Tree

Anas Al-okaily
Abdelghani Tbakhi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1577324

Original Research

Published on 07 Aug 2025

Internal fossil constraints have more effect on the age estimates of crown Palaeognathae than different phylogenomic data type

Alexandre Pedro Selvatti
Naoko Takezaki

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1563786

204 views

Original Research

Accepted on 06 Aug 2025

Drug discovery for chemotherapeutic resistance based on pathway-responsive gene sets and its application in breast cancer

DeHua Feng
Jingwen Hao
Lingxu Li
Jian Chen
Xinying Liu
Ruijie Zhang
Huirui Han
Tianyi Li
Xuefeng Wang
Xia Li

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1661601

Brief Research Report

Accepted on 05 Aug 2025

Association between Dysregulated Expression of Ca 2+ and ROS-Related Genes and Breast Cancer Patient Survival

Sofia Ramos
João Gregório
Ana Sofia Fernandes
Nuno Saraiva

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1633494

Original Research

Accepted on 05 Aug 2025

Spatial Heterogeneity Reveals an Evolutionary Signature Predicting Therapeutic Response and Clinical Outcomes in Hepatocellular Carcinoma

Shangyi Luo
Li Liu
Yang Sun
Jian Shi
Yajing Zhang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1669236

126 views

Original Research

Published on 05 Aug 2025

In silico analysis of CSF2RB from cancer genomic databases reveals a heterogeneous role in different breast cancer subtypes

Raghad Alshelaiel
Abdulmohsen Alkushi
Lolwah Abdullah Alriyees
Abir Abdullah Alamro
Humidah Alanazi
Areej Alhareeri
Bader AlMuzzaini
Mamoon Rashid

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1606828

264 views

Original Research

Published on 01 Aug 2025

Bioinformatics analysis of lncRNA and mRNA differentially expressed in patients with cervical cancer

Xiaohua An
Xiaoxue Huang
Qiujie Yu
Yiyue Tang
Yan Wang
Huasu Chen
Yafei Zhang
Qianhao Huang
Yudi Rao
Guomei Hu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1605681

398 views

Original Research

Published on 01 Aug 2025

The bacteriostatic regulation of luteolin from honeysuckle by protein network interaction

Jianfeng Zhang
Mujun Chen
Dianzeng Yang
Yanjie Jia

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1637479

281 views

Perspective

Accepted on 30 Jul 2025

Advancing Bioinformatics Capacity through Nextflow and nf-core: Lessons from an Early-to Mid-Career Researchers-Focused Program at The Kids Research Institute Australia.Golden rules for building sustainable bioinformatics capacity using Nextflow and nf-core with a focus on earlymid career researchers: The Kids Research Institute Australia, case report

Patricia Agudelo-Romero
Talya Conradie
Jose Antonio Caparros-Martin
David Jimmy Martino
Anthony Kicic
Stephen Michael Stick
Christopher Hakkaart
Abhinav Sharma

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1610015

206 views

Original Research

Accepted on 29 Jul 2025

Using reinforcement learning in genome assembly: in-depth analysis of a Q-learning assembler

Kleber Padovani
Rafael Cabral Borges
Roberto Xavier
André Carlos Ponce De Leon Ferreira De Carvalho
Anna Reali
Annie Chateau
Ronnie Alves

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1633623

397 views

Methods

Accepted on 29 Jul 2025

Quantitative measures to assess the quality of Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq) data

Jie Sun
Robert Morrison
Soyeon Kim
Kairuo Yan
Hyun Jung Park

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1630161

150 views

Data Report

Accepted on 28 Jul 2025

Germline mutation profiling of breast cancer patients by using non-BRCA sequencing panel

Sonar Panigoro
Rafika Indah Paramita
Fadilah Fadilah
Septelia Inawati Wanandi
Aisyah Fitriannisa Prawiningrum
Linda Erlina
Wahyu Dian Utari
Ajeng Megawati Fajrin

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1620025

239 views

Original Research

Accepted on 28 Jul 2025

Sequence-Based Prioritization of i-Motif Candidates in the Human Genome

Mauro Fasano
Veronica Remori
Michela Prest

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1657841

217 views

Original Research

Published on 28 Jul 2025

Computational investigation of potential natural compounds as inhibitors of monkeypox virus cysteine proteinase

Riya Nalwa
Anis Ahmad Chaudhary
Mandeep Chouhan
Prashant Kumar Tiwari
Saurabh Gupta
Hassan Ahmed Rudayni
Vivek Dhar Dwivedi
Sanjay Kumar

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1637207

636 views

Original Research

Published on 28 Jul 2025

Integrative machine learning and bioinformatics analysis to identify cellular senescence-related genes and potential therapeutic targets in ulcerative colitis and colorectal cancer

Tianle Xue
Yunpeng Chen
Xiaomeng Li
Zhixiang Zhou
Qiyang Chen

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1599098

546 views

492 Publications

Volume 5 - 2025

Identifying Novel Therapeutic Targets for Non-Alcoholic Fatty Liver Disease Using Bioinformatics Approaches: From Drug Repositioning to Traditional Chinese Medicine

A Novel Linear Indexing for Strings under all Internal Nodes in a Suffix Tree

Internal fossil constraints have more effect on the age estimates of crown Palaeognathae than different phylogenomic data type

Drug discovery for chemotherapeutic resistance based on pathway-responsive gene sets and its application in breast cancer

Association between Dysregulated Expression of Ca 2+ and ROS-Related Genes and Breast Cancer Patient Survival

Spatial Heterogeneity Reveals an Evolutionary Signature Predicting Therapeutic Response and Clinical Outcomes in Hepatocellular Carcinoma

In silico analysis of CSF2RB from cancer genomic databases reveals a heterogeneous role in different breast cancer subtypes

Bioinformatics analysis of lncRNA and mRNA differentially expressed in patients with cervical cancer

The bacteriostatic regulation of luteolin from honeysuckle by protein network interaction

Using reinforcement learning in genome assembly: in-depth analysis of a Q-learning assembler

Quantitative measures to assess the quality of Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq) data

Germline mutation profiling of breast cancer patients by using non-BRCA sequencing panel

Sequence-Based Prioritization of i-Motif Candidates in the Human Genome

Computational investigation of potential natural compounds as inhibitors of monkeypox virus cysteine proteinase

Integrative machine learning and bioinformatics analysis to identify cellular senescence-related genes and potential therapeutic targets in ulcerative colitis and colorectal cancer