Frontiers in Bioinformatics

Original Research

Published on 14 May 2026

MRI abdominal fat segmentation with a novel VAT/SAT delineation algorithm: Otsu regression calibration and comparison to k-means and fuzzy c-means

Mihai Octavian Negrea
Bogdan Neamtu
Denisa Claudia Roman
Darius Peteleaza
Ciprian Sofariu
Raluca Maria Costea
Olga Brusnic

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1752522

354 views

Editorial

Accepted on 13 May 2026

Editorial: AI in single-cell biology

Martin Hemberg

Frontiers in Bioinformatics

Original Research

Published on 13 May 2026

Predicting anthropometric body composition variables using 3D optical imaging and machine learning

Gyaneshwar Agrahari
Kiran Bist
Monika Pandey
Jacob Kapita
Zachary James
Jackson Knox
Steven Heymsfield
Sophia Ramirez
Peter Wolenski
Nadejda Drenska

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1722578

331 views

Original Research

Accepted on 12 May 2026

Hydrogen Sulfide Modulates Gene Networks in Hypoxia/Reoxygenation-Stressed Trophoblasts: Insights from Transcriptome Profiling

Shivani Shivani
Amit Katiyar
Sunil Kumar Gupta
Pallavi Arora
Kiran Kumari
Tooba Tahreem Khan
Pallavi Kshetrapal
Renu Dhingra

Frontiers in Bioinformatics

Original Research

Accepted on 12 May 2026

Immunoinformatic-guided design of a polo-like kinase 1 (PLK1)-targeted multi-epitope vaccine with preliminary in vitro validation

Gayatri Munieswaran
Nandha Kumar Subramani
Anand Prem Rajan
Venkatraman Manickam

Frontiers in Bioinformatics

Review

Published on 12 May 2026

Preoperative APOE and Alzheimer’s disease polygenic risk profiling for perioperative neurocognitive disorders

Mengquan Tan
Jiling Zeng
Huixian Zhou
Shilin Yang
Tong Wang
Meiling Zhong
Tongyu Wang
Zheng Liu
Yaling Dai
Siyuan Song

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1829278

516 views

Original Research

Published on 12 May 2026

NOVAGene: a nonlinear approach to improve biological resolution in weighted gene co-expression networks for low-variability datasets

Junelle Rey C. Bacong
Jose Jr B. Nevado
Marissa M. Alejandria
Maria Sonia S. Salamat
Joseph Adrian L. Buensalido

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1813626

387 views

Review

Published on 12 May 2026

Temporal network analysis in systems biology: concepts, inference, and validation

Abir Khazaal
Fatemeh Vafaee

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1822526

452 views

Original Research

Accepted on 11 May 2026

Pharmacokinetics, mMolecular dDocking, and mMolecular dDynamics sSimulation uUnveil nNovel lLichen-dDerived sScaffolds tTargeting PBP2a MRSA

Shalini Swami
Ayushi Priya
N. Venkatesh
Abhishek Rao
Sunila Hooda
Lakshay Devrani
Deepansha Raina
Gaurav Selva

Frontiers in Bioinformatics

Original Research

Accepted on 11 May 2026

Integrative Phosphoproteomic Analysis Identifies Functional Roles of TRPM7 Phosphosites in Oncogenesis

Akhina Palollathil
Althaf Mahin
Athira Perunelly Gopalakrishnan
Alimath Sambreena
PRATHIK B S
Rajesh Raju

Frontiers in Bioinformatics

Original Research

Accepted on 11 May 2026

Integrated Computational-Based Design of Putative Dual TrkA/TrkB Agonists for Alzheimer's Disease: Pharmacophore Modelling, Docking, MM/GBSA, DFT and Dynamics Studies

Vignesh Pandi A
Vishnu Malakar
Jeyaram Bharathi Jeyabalan
Krishna Shevate
Dr. Kalirajan Rajagopal
Prashantha Kumar BR
Antony Justin

Frontiers in Bioinformatics

Original Research

Accepted on 11 May 2026

Real-world chronic recordings from implantable adaptive deep brain stimulation systems for Parkinson's Disease Motor State Classification

Hanan Awad Hassan Ali
Matteo Guidetti
Laura Caffi
Mattia Arlotti
Lorenzo Rossi
Chiara Palmisano
Alberto Priori
Francesco Brun
Ioannis Ugo Isaias
Sara Marceglia

Frontiers in Bioinformatics

Original Research

Accepted on 11 May 2026

Polygenic modeling of genetic effects on both phenotypic mean and variance: Distributional regression for BMI, blood and urine biomarkers in the UK Biobank

Kiran Kunwar
Qiong Wu
Hannah Klinkhammer
Christian Staerk
Andreas Mayr
Carlo Maj

Frontiers in Bioinformatics

Methods

Published on 11 May 2026

Weak-to-strong generalization enables fully automated training of multi-head mask-RCNN model for segmenting densely overlapping cell nuclei in multiplex whole-slice brain images

Lin Bai
Xiaoyang Li
Liqiang Huang
Quynh Nguyen
Hien Van Nguyen
Saurabh Prasad
Dragan Maric
John Redell
Pramod Dash
Badrinath Roysam

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1733655

505 views

Original Research

Accepted on 08 May 2026

BIOGEN: Evidence-Grounded Multi-Agent Reasoning Framework for Transcriptomic Interpretation in Antimicrobial Resistance

Elias Hossain
Mehrdad Shoeibi
Ivan Garibay
Niloofar Yousefi

Frontiers in Bioinformatics

141 views

Original Research

Published on 08 May 2026

HVIface: sequence-based deep learning for decoding human-virus protein-protein interfaces

Krishna Kant Gupta
Monty Vijayvargiya
Geetha Paul
Ninan Sajeeth Philip
Radha Chauhan

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1813796

544 views

Brief Research Report

Accepted on 07 May 2026

ONYX: An alignment-free biological sex inference from high-throughput sequencing data

Koji Ishiya

Frontiers in Bioinformatics

157 views

Original Research

Accepted on 07 May 2026

Machine Learning-Based Classification of COVID-19 Severity Using Respiratory Microbiome Profiles from Shotgun Metagenomic Sequencing

Eli Gabriel Avina-Bravo
Isabel Gracía-Lorenzo
Mariel Alfaro-Ponce
Luz Breton-Deval

Frontiers in Bioinformatics

141 views

Original Research

Published on 07 May 2026

Comparative transcriptomics and computational drug discovery identify ASPM as a key oncogenic driver and therapeutic target in hepatocellular carcinoma

Pan Li
Aiye Guo
MingJing Zhao
GuangHui Chen

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1795889

356 views

Original Research

Accepted on 04 May 2026

Integrative Transcriptomics and Structure-Based Screening Identifies Phyllanthus amarus Phytocompounds as Potential WNT5A Modulators in Ovarian Cancer

Shreya Shibu
Abisha Sharon
Sidharth Kumar N
Vasundra Vasudevan
Tarsha S M
Madhana Priya N
Dr Thirumal Kumar D
Magesh Ramasamy

Frontiers in Bioinformatics

186 views

Review

Accepted on 04 May 2026

Resources and applications of public biomedical data

Liu Mingrui
Zelin Ye
Haiyu Liu
Pengzhen Ma
Huaxin Pang
Yaning Li
Qihao Wang
Yikang Shen
Xiaoxia Xie
Yufeng Zhao

Frontiers in Bioinformatics

155 views

Original Research

Accepted on 04 May 2026

Association of FCRL3 Gene Variants with Rheumatoid Arthritis Susceptibility in the Indian Population: A Combined Case-Control and In-Silico Analysis

Asha Devi S
Mohamed Muzammil.S

Frontiers in Bioinformatics

145 views

Original Research

Published on 04 May 2026

Discovering TEAD4 modulators for hepatocellular carcinoma: a GAN-enabled generative modelling framework

Varshni Premnath
Ramanathan Karuppasamy
Jayakumar Kaliappan
Shanthi Veerappapillai

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1811161

369 views

Original Research

Published on 04 May 2026

Delineating novel diagnostic biomarkers and therapeutic targets for oral submucosal fibrosis: an integrative multi-omics and machine learning approach

Chinmay Nitin Mokal
Piyush Agrawal

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1803111

441 views

709 Publications

volumes

Volume 6 - 2026

MRI abdominal fat segmentation with a novel VAT/SAT delineation algorithm: Otsu regression calibration and comparison to k-means and fuzzy c-means

Editorial: AI in single-cell biology

Predicting anthropometric body composition variables using 3D optical imaging and machine learning

Hydrogen Sulfide Modulates Gene Networks in Hypoxia/Reoxygenation-Stressed Trophoblasts: Insights from Transcriptome Profiling

Immunoinformatic-guided design of a polo-like kinase 1 (PLK1)-targeted multi-epitope vaccine with preliminary in vitro validation

Preoperative APOE and Alzheimer’s disease polygenic risk profiling for perioperative neurocognitive disorders

NOVAGene: a nonlinear approach to improve biological resolution in weighted gene co-expression networks for low-variability datasets

Temporal network analysis in systems biology: concepts, inference, and validation

Pharmacokinetics, mMolecular dDocking, and mMolecular dDynamics sSimulation uUnveil nNovel lLichen-dDerived sScaffolds tTargeting PBP2a MRSA

Integrative Phosphoproteomic Analysis Identifies Functional Roles of TRPM7 Phosphosites in Oncogenesis

Integrated Computational-Based Design of Putative Dual TrkA/TrkB Agonists for Alzheimer's Disease: Pharmacophore Modelling, Docking, MM/GBSA, DFT and Dynamics Studies

Real-world chronic recordings from implantable adaptive deep brain stimulation systems for Parkinson's Disease Motor State Classification

Polygenic modeling of genetic effects on both phenotypic mean and variance: Distributional regression for BMI, blood and urine biomarkers in the UK Biobank

Weak-to-strong generalization enables fully automated training of multi-head mask-RCNN model for segmenting densely overlapping cell nuclei in multiplex whole-slice brain images

BIOGEN: Evidence-Grounded Multi-Agent Reasoning Framework for Transcriptomic Interpretation in Antimicrobial Resistance

HVIface: sequence-based deep learning for decoding human-virus protein-protein interfaces

ONYX: An alignment-free biological sex inference from high-throughput sequencing data

Machine Learning-Based Classification of COVID-19 Severity Using Respiratory Microbiome Profiles from Shotgun Metagenomic Sequencing

Comparative transcriptomics and computational drug discovery identify ASPM as a key oncogenic driver and therapeutic target in hepatocellular carcinoma

Integrative Transcriptomics and Structure-Based Screening Identifies Phyllanthus amarus Phytocompounds as Potential WNT5A Modulators in Ovarian Cancer

Resources and applications of public biomedical data

Association of FCRL3 Gene Variants with Rheumatoid Arthritis Susceptibility in the Indian Population: A Combined Case-Control and In-Silico Analysis

Discovering TEAD4 modulators for hepatocellular carcinoma: a GAN-enabled generative modelling framework

Delineating novel diagnostic biomarkers and therapeutic targets for oral submucosal fibrosis: an integrative multi-omics and machine learning approach