MINI REVIEW article
Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1549857
The relationship between programmed cell death and vascular calcification
Provisionally accepted
- Affiliated Nanhua Hospital, University of South China, Hengyang, China
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Vascular calcification (VC) is a pathological condition closely associated with a range of cardiovascular diseases, including atherosclerosis (AS), hypertension, vascular injury, and diabetic angiopathy. Programmed cell death, encompassing apoptosis, autophagy, pyroptosis and ferroptosis, plays a pivotal role in the progression of VC. These cellular processes are intricately regulated by multiple signaling pathways, such as the Wnt/β-catenin and NF-κB pathways, among others. A deeper understanding of the roles and underlying mechanisms of programmed cell death in VC could offer valuable insights for the development of innovative therapeutic strategies targeting cardiovascular diseases.
Keywords: Vascular Calcification, programmed cell death, Signaling Pathways, Diabetic angiopathy, Atherosclerosis
Received: 22 Dec 2024; Accepted: 25 Jun 2025.
Copyright: © 2025 Liu, Zheng, Lin and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianghua Liu, Affiliated Nanhua Hospital, University of South China, Hengyang, China
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