ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Clinical and Translational Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1571610
Association of estimated pulse wave velocity with all-cause mortality and cardiovascular mortality in obstructive sleep apnea patients: Results from NHANES
Provisionally accepted
- 1Department of Cardiology, Fujian Medical University Union Hospital, Fujian, China
- 2Fujian Medical University, Fuzhou, Fujian Province, China
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Background: This study aims to investigate the relationship between estimated pulse wave velocity (ePWV) and all-cause mortality (ACM) and cardiovascular mortality (CVM) in patients with obstructive sleep apnea (OSA).A cohort study was conducted using data from the NHANES database (2005)(2006)(2007)(2008)(2015)(2016)(2017)(2018), focusing on adults with OSA. ePWV was calculated based on age and mean blood pressure. A weighted Cox regression model analyzed the association of ePWV with ACM and CVM, while restricted cubic spline (RCS) curves visualized this relationship. Kaplan-Meier (KM) survival curves assessed survival across different ePWV groups.The study involved 10,071 OSA patients with an average age of 48.46 years, with a follow-up period ending in December 2019 (average follow-up time: 102.10 ± 2.34 months). Results showed that increased ePWV correlated with higher ACM (hazard ratio [HR]: 1.25, 95% confidence interval [CI]: 1.20-1.31) and CVM (HR: 1.28, 95% CI: 1.21-1.36). RCS curves indicated stable mortality risks at ePWV ≤ 8.1 m/s, with rapid increases beyond this threshold. KM curves demonstrated poorer survival outcomes for OSA patients with elevated ePWV. Conclusion:Elevated ePWV levels are linked to increased ACM and CVM in OSA patients, suggesting that monitoring ePWV could help mitigate these risks and promote healthier longevity in this population.
Keywords: estimated pulse wave velocity, obstructive sleep apnea, arterial stiffness, NHANES, All-cause mortality, Cardiovascular mortality
Received: 06 Feb 2025; Accepted: 29 May 2025.
Copyright: © 2025 Lin, Zheng, Lin and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Tao Lin, Fujian Medical University, Fuzhou, 350108, Fujian Province, China
Lianglong Chen, Department of Cardiology, Fujian Medical University Union Hospital, Fujian, China
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