REVIEW article
Front. Cardiovasc. Med.
Sec. Cardio-Oncology
This article is part of the Research TopicCardio-Oncology in the Era of Precision Medicine: Risk Stratification, Surveillance, and Cardioprotection Across the Cancer ContinuumView all articles
Cancer Therapy-Related Cardiovascular Aging: Mechanisms, Monitoring, and Intervention Strategies
Provisionally accepted
- 1Jiangsu University, Zhenjiang, China
- 2Zhenjiang First People's Hospital, Zhenjiang, China
- 3Affiliated Hospital of Jiangsu University, Zhenjiang, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Significant improvements in cancer survival rates have been achieved through advancements in treatment and early diagnosis. However, non-cancer-related mortality among cancer survivors continues to rise each year. Cardiovascular diseases (CVDs) related to cancer therapy now rank as the second leading cause of death in survivors, sometimes surpassing the cancer itself. Among these, cardiovascular aging represents one of the most severe side effects, often leading to detrimental structural changes such as cardiac atrophy or fibrosis, which ultimately impair cardiac function and reduce survival. Preventing or treating cardiovascular aging has emerged as a promising strategy to mitigate Cancer Therapy-Related Cardiovascular Toxicity (CTR-CVT). This review offers a comprehensive analysis of the characteristics and mechanisms underlying cancer therapy-induced accelerated cardiovascular cellular senescence, outlines current monitoring and intervention strategies, and explores future research opportunities and challenges. Enhancing the understanding of Cancer Therapy-Related Cardiovascular Cellular Senescence and Cancer Therapy-Related Cardiovascular Aging (CTR-CVA) is crucial for optimizing cancer treatment, advancing medical research, and improving clinical practice, all of which are vital for preserving cardiac health and improving the quality of life of patients with cancers.
Keywords: cancer therapy, Cardiovascular aging, cellular senescence, Mechanism, Monitoring
Received: 18 Jul 2025; Accepted: 08 Dec 2025.
Copyright: © 2025 Lin, Wu, Liu and Liao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiang Liao
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.