CASE REPORT article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
This article is part of the Research TopicCase Reports in Coronary Artery Disease: 2025View all 21 articles
Case Report: Left Main Coronary Artery Spasm in Monozygotic Twins patients with Vasospastic Angina
Provisionally accepted
- First Affiliated Hospital of Gannan Medical University, Ganzhou, China
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Coronary artery spasm (CAS), a known cause of myocardial ischemia that can present as variant angina, is primarily triggered by intraoperative catheter manipulation. Evidence for a genetic predisposition to coronary artery spasm is scarce. This report describes a case involving identical twins with no conventional cardiovascular risk factors who successively developed CAS. Their coronary angiograms showed spontaneous spasm in left main coronary artery, left circumflex branch artery and left anterior descending artery. This case provides clinical evidence for a genetic predisposition to CAS, highlighting the critical need for familial screening— particularly the proactive screening of the other twin when one monozygotic twin is diagnosed with vasospastic angina.
Keywords: Coronary artery spasm, vasospastic angina, Left main coronary artery, Genetics, Identical twins, case report
Received: 01 Oct 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Xie, Liao, Liu, Yi, Luhui, Liu, Xie and Ling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiahe Xie
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