STUDY PROTOCOL article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Integrative Multi-omics Profiling of Mild Cognitive Impairment in Older Patients Combined with Coronary Heart Disease: A Cross-sectional Cohort Study
1. Beijing University of Chinese Medicine, Beijing, China
2. Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China, 100091
3. Laboratory of Combining Diseases and Evidence to Prevent Vascular Aging, National Administration of Traditional Chinese Medicine, Beijing, China
4. Department of Integrated Traditional and Western Medicine, Peking University Health Science Center, Beijing, China
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Abstract
Introduction: With the escalating global burden of population ageing, the comorbidity of geriatric coronary heart disease (CHD) and mild cognitive impairment (MCI) has emerged as a significant public health concern. This study aims to elucidate the underlying clinical disease features of MCI in elderly CHD patients through comprehensive multi-omics analyses and to establish a detailed phenomics profile. Methods: A cross-sectional study design will be implemented, enrolling 364 elderly patients diagnosed with CHD. Participants will be divided into MCI and cognitively normal groups based on Montreal Cognitive Assessment (MoCA) scores. Extensive data collection will include demographic characteristics, clinical parameters, laboratory investigations, and echocardiographic findings. These clinical data will be integrated with multi-omics analyses (including genomics, proteomics, and metabolomics) to identify differential biomarkers between the two groups. Discussion: This study anticipates constructing an integrative network map delineating the multi-omics mechanisms underlying MCI in elderly CHD patients by correlating macroscopic clinical phenotypes with microscopic molecular characteristics. The findings are expected to provide a scientific foundation for early detection and intervention strategies. While acknowledging the inherent limitations of the cross-sectional design, future prospective studies are warranted to validate these findings. This investigation offers novel insights and potential therapeutic strategies for the prevention and management of comorbid CHD and MCI in the ageing population. This study has completed registration in the International Traditional Medicine Clinical Trial Registration Platform (ITMCTR2024000871).
Summary
Keywords
coronaryheartdisease2, cross-sectional cohort study5, elderlypopulation1, mildcognitiveimpairment3, multi-omics profiling4
Received
30 March 2025
Accepted
29 January 2026
Copyright
© 2026 Li, Yue-Ying, Hui, Zou, Qi and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Fengqin Xu
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