SYSTEMATIC REVIEW article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
A systematic review and meta-analysis of the efficacy of addition and reduction of Shixiao Powder in the treatment of coronary heart disease
Provisionally accepted
- 1Zhejiang Chinese Medical University, Hangzhou, China
- 2Tongde Hospital of Zhejiang Province, Hangzhou, China
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Objective: To evaluate the effectiveness and safety of combining Shixiao Powder with Western medicine for treating coronary heart disease-induced angina. Methods: The databases CNKI, VIP, Wanfang, SinoMed, PubMed, Embase, Web of Science, and Cochrane were searched until March 19th, 2024 for randomized controlled studies on the treatment of angina pectoris in coronary heart disease using Shixiao Powder combined with Western medicine. Quality assessment was conducted using the Cochrane Collaboration's tool. Heterogeneity was tested using the Chi-squared-based Q statistic test and I2 statistic. Results: The study included a total of 15 articles, with 1204 patients in the cohort, divided into 625 cases in the observation group and 579 cases in the control group. Compared to Western medicine alone, the combination of Shixiao powder and Western medicine significantly improved the effective rate in treating angina pectoris of coronary heart disease [RR=1.25, 95%Cl (1.18-1.32), P < 0.00001]. The improvement in ECG ST segment was superior [RR=1.32, 95%Cl (1.21-1.43), P < 0.00001]. Additionally, there was a decrease in serum CRP level [WMD=-0.8, 95%Cl (-1.43 -- 0.18), Z=2.52, P=0.012 < 0 .05]. The assessment of publication bias concluded that there was no publication bias, suggesting that the conclusions of this study are accurate and reliable. Conclusion: The current evidence supports that combining Shixiao Powder with Western medicine effectively and safely treats angina pectoris associated with coronary heart disease.
Keywords: Angina Dectoris, coronary heart disease, Curative effect, Meta-analysis, Shixiao Powder
Received: 05 Sep 2025; Accepted: 06 Feb 2026.
Copyright: © 2026 Chen, Shen, Su, Zhou and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yaping Li
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